New polyaza macrobicyclic binucleating ligands and their binuclear copper(II) complexes: Electrochemical, catalytic and DNA cleavage studies

Effect of the central metal ion on the cleavage of DNA by [M(TPA)Cl]ClO4 complexes (M=CoII, CuII and ZnII, TPA=tris(2-pyridylmethyl)amine): An efficient artificial nuclease for DNA cleavage

“…In addition, cobalt(III) complexes have also been extensively investigated and reported to reveal high catalytic activity [34][35][36][37][38]. Zinc(II) and copper(II) complexes derived from a wide range of ligands of varied skeletal structures and geometrical environments were found to be useful models for phosphodiester substrates [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][25][26][27][28][29][30][31]. Although it has been reported that binuclear metal complexes are in general more efficient in hydrolyzing the phosphate ester and DNA cleavage reactions [7,10,13,[29][30][31]37] compared to the related mononuclear species, many mononuclear complexes still function as good catalysts [19,8,[20][21][22]31,36,38].…”

“…Mononuclear copper(II) complexes with various ligands including tripods, tetradendate amines and macrocycles have been employed in the hydrolysis of phosphate esters and of DNA [2,[8][9][10][11][14][15][16][17][18][19]. Under physiological conditions, the cleavage of bis (4-nitrophenyl)-phosphate and of DNA by the 9-membered macrocycle 1,4,7-triazacyclononane (=tacn = [9]aneN 3 ) and its N-alkylated derivatives [Cu(R 3 ) [9]aneN 3 ] 2+ was found to increase with increasing the steric bulkiness of the ligand [14,15].…”

“…Under physiological conditions, the cleavage of bis (4-nitrophenyl)-phosphate and of DNA by the 9-membered macrocycle 1,4,7-triazacyclononane (=tacn = [9]aneN 3 ) and its N-alkylated derivatives [Cu(R 3 ) [9]aneN 3 ] 2+ was found to increase with increasing the steric bulkiness of the ligand [14,15]. A parallel trend was also observed in copper(II) complexes derived from N-alkylated-tach (tach = 1,3,5-triaminocyclohexane) [16,19] and from cyclen (1,4,7,11-tetraazacyclododecane) complexes containing an imidazolium and a peptide nucleic acid (PNA) [17,18].…”

Metal Complexes of N-[Morpholine-4-Yl-(4- Nitrophenyl)-Methyl]-Benzamide: Synthesis, Characterization and Evaluation of Pesticidal and Larvicidal Activity

“…The mode of coordination and its" sites were pointed out by comparing the IR spectrum of ligand and its complexes. [28,29,30] IR data concludes that the ligand acts as a bidentate and coordination occurs through O and N atoms to the metal ions. …”

Synthesis and characterization of cobalt(II), nickel(II) and copper(II)-based potential photosensitizers: Evaluation of their DNA binding profile, cleavage and photocytotoxicity

“…S1). In comparison with the spectra of the Schiff base, all the metal complexes exhibit downward shift of about 11-20 cm -1 in the band of ν(C=N) indicating the participation of azomethine nitrogen in the coordination to metal ion[58].The most notable change in the Schiff base spectral features when coordinated to metal ion is the lower shift of amide ν(C=O) vibration to the extent of about 16-25 cm -1 , suggesting that, the metal is coordinated to the amide carbonyl oxygen atom[59][60][61][62]. As the thiophene is a very poor ligand[63], the ν(C-S) observed at 786 cm -1 in the ligand L remains at the same position in the complexes indicating non-coordination of thiophene ring sulfur to the metal, in agreement with previous results[45,62,[64][65][66].…”