New Polymeric Films with Antibacterial Activity Obtained by UV-induced Copolymerization of Acryloyloxyalkyltriethylammonium Salts with 2-Hydroxyethyl Methacrylate

Abstract

New polymeric films with antibacterial activity have been prepared, by simple UV-induced copolymerization of readily available ω-(acryloyloxy)-N,N,N-triethylalcan-1-aminium bromides (or acryloyloxyalkyltriethylammonium bromides, AATEABs) with commercially available 2-hydroxyethyl methacrylate (HEMA), at different relative amounts. In particular, the antibacterial activity of polymeric films derived from 11-(acryloyloxy)-N,N,N-triethylundecan-1-aminium bromide (or acryloyloxyundecyltriethylammonium bromide, AUTEAB; bearing a C-11 alkyl chain linker between the acrylate polymerization function and the quaternary ammonium moiety) and 12-(acryloyloxy)-N,N,N-triethyldodecan-1-aminium bromide (or acryloyloxydodecyltriethylammonium bromide, ADTEB, bearing a C-12 alkyl chain linker) has been assessed against Gram-negative Escherichia Coli and Gram-positive Staphylococcus aureus cells. The results obtained have shown a clear concentration-dependent activity against both bacterial strains, the films obtained from homopolymerization of pure AUTEAB and ADTEAB being the most effective. Moreover, ADTEAB-based films showed a higher antibacterial activity with respect to the AUTEAB-based ones. Interestingly, however, both types of films presented a significant activity not only toward Gram-positive S. aureus, but also toward Gram-negative E. Coli cells.

In Situ Application of Anti-Fouling Solutions on a Mosaic of the Archaeological Park of Ostia Antica

“…Hence, antimicrobial polymeric films based on quaternary ammonium salts have recently gained interest in the development of new biocide protective systems. They combine the ability of quaternary ammonium salts to exchange ions between the membrane cell and positively charged groups, causing the disintegration of the membrane and, consequently, the cell death with polymerizable function [20]. Polymers are non-volatile and low toxic.…”

Polymeric Systems as Antimicrobial or Antifouling Agents

“…Cationic acrylic copolymers based on poly(2-hydroxy ethyl methacrylate) (HEMA), a largely employed biocompatible polymer, were investigated in 2 of the 15 studies of this special issue [29,30]. Specifically, Muñoz-Bonilla et al [29] copolymerized HEMA with a methacrylic monomer bearing a thiazole side group susceptible to quaternization, while Galiano et al [30] used UV-induced polymerization to copolymerize HEMA with two cationic acryloyloxyalkyltriethylammonium bromides (C-11 or C-12 alkyl chain linker).…”

Polymeric Systems as Antimicrobial or Antifouling Agents

“…Among the antimicrobial systems, readers can find antimicrobial peptides [23,24,25,26], cationic polymers [27,28,29,30,31], and inorganic/polymer composites [32,33,34].…”

“…Cationic acrylic copolymers based on poly(2-hydroxy ethyl methacrylate) (HEMA), a largely employed biocompatible polymer, were investigated in 2 of the 15 studies of this special issue [29,30]. Specifically, Muñoz-Bonilla et al [29] copolymerized HEMA with a methacrylic monomer bearing a thiazole side group susceptible to quaternization, while Galiano et al [30] used UV-induced polymerization to copolymerize HEMA with two cationic acryloyloxyalkyltriethylammonium bromides (C-11 or C-12 alkyl chain linker). In both studies, copolymers exhibited significant activity versus Gram-positive ( S. aureus ) and Gram-negative ( P. aeruginosa and E. coli ) bacteria and, as expected, copolymer antimicrobial activity increased with increasing of the cationic unit content.…”