New Polymers for Needleless Electrospinning from Low-Toxic Solvents

Wortmann, Martin; Frese, Natalie; Sabantina, Lilia; Petkau, Richard; Kinzel, Franziska; Moritzer, Elmar; Hüsgen, Bruno; Ehrmann, Andrea

doi:10.3390/nano9010052

Cited by 47 publications

(44 citation statements)

References 36 publications

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“…Several solvents which are oft en used in electrospinning, however, are toxic or corrosive. While a large number of biopolymers can be electrospun from water [6,7], only few waterresistant polymers can be spun from low-toxic solvents such as dimethyl sulfoxide (DMSO) [8]. Th is is one of the reasons why polyacrylonitrile (PAN) is of large interest in electrospinning, apart from its usability as a precursor for carbon nanofi bres [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Sterilization of PAN/Gelatine Nanofibrous Mats for Cell Growth

Wehlage¹,

Blattner²,

Sabantina³

et al. 2019

TEK

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Nanofi brous mats can be used as a substrate for eukaryotic cell growth in biotechnology, tissue engineering, etc. Several adherent cells (e.g. human fi broblasts) have been shown to grow well on fi ne fi bres. For most applications, it is necessary to sterilize nanofi brous mats before adding the cells. Another possibility would be the addition of antibiotics and antimycotics to the cell culture medium to prevent microbial infection. However, antibiotics are disadvantageous since they might promote the growth of resistant bacteria in possible future medical applications of nanofi brous mats. Possible sterilization techniques include autoclaving, UV-sterilization, ozone treatment, heat sterilization and other techniques which usually necessitate more expensive equipment, such as gamma irradiation. Systematic examinations of the infl uence of diff erent sterilization techniques on the cell growth on nanofi brous mats have not yet been reported in the literature. Here, we report on the fi rst experimental investigations of the eff ect of sterilization with diff erent methods on the properties of polyacrylonitrile (PAN)/gelatine nanofi brous mats, and the resulting growth and adhesion of Chinese hamster ovary cells. While all techniques under investigation yielded sterile nanofibrous mats, autoclaving and heat sterilization change the PAN/gelatine fi bre morphology. Ozone, on the other hand, modifi es the pH value of the culture medium and partly impedes cell adhesion. UV sterilization also suggests a chemical modifi cation of the nanofi brous mat. Unexpectedly, heat sterilization resulted in the highest amount of adherent Chinese hamster ovary cells grown on PAN/gelatine nanofi brous mats in spite of gelatine melting.

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Section: Introductionmentioning

confidence: 99%

Sterilization of PAN/Gelatine Nanofibrous Mats for Cell Growth

Wehlage¹,

Blattner²,

Sabantina³

et al. 2019

TEK

Self Cite

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“…According to the electrospinning raw materials, it can be divided into melt electrospinning [46][47][48], solution electrospinning [49,50] and mixed electrospinning [51][52][53]. According to the design of the spray head, it can be classified as needleless electrospinning [54][55][56], coaxial or triaxial electrospinning [57][58][59][60][61][62], multi-jet electrospinning [63][64][65], etc. The application of electrospinning technology will be described below according to different situations.…”

Section: Strategies For the Preparation Of Functional Electrospun Matmentioning

confidence: 99%

Electrospun Functional Materials toward Food Packaging Applications: A Review

et al. 2020

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Electrospinning is an effective and versatile method to prepare continuous polymer nanofibers and nonwovens that exhibit excellent properties such as high molecular orientation, high porosity and large specific surface area. Benefitting from these outstanding and intriguing features, electrospun nanofibers have been employed as a promising candidate for the fabrication of food packaging materials. Actually, the electrospun nanofibers used in food packaging must possess biocompatibility and low toxicity. In addition, in order to maintain the quality of food and extend its shelf life, food packaging materials also need to have certain functionality. Herein, in this timely review, functional materials produced from electrospinning toward food packaging are highlighted. At first, various strategies for the preparation of polymer electrospun fiber are introduced, then the characteristics of different packaging films and their successful applications in food packaging are summarized, including degradable materials, superhydrophobic materials, edible materials, antibacterial materials and high barrier materials. Finally, the future perspective and key challenges of polymer electrospun nanofibers for food packaging are also discussed. Hopefully, this review would provide a fundamental insight into the development of electrospun functional materials with high performance for food packaging.

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“…Frequence (%) MBE MFSE OSFSE SSFSE 4.0×10 5 ˂ ER ≤ 4.4×10 5 0.00 0.00 24.88 0.00 4.4×10 5 ˂ ER ≤ 4.8×10 5 0.00 0.00 21.39 0.00 4.8×10 5 ˂ ER ≤ 5.2×10 5 23.88 0.00 9.95 0.00 5.2×10 5 ˂ ER ≤ 5.6×10 5 31.84 0.00 5.97 0.00 5.6×10 5 ˂ ER ≤ 6.0×10 5 16.42 69.11 3.48 0.00 6.0×10 5 ˂ ER ≤ 6.4×10 5 4.98 10.99 2.49 51.67 6.4×10 5 ˂ ER ≤ 6.8×10 5 2.99 5.24 1.99 10.00 6.8×10 5 ˂ ER ≤ 7.2×10 5 2.49 2.62 1.99 6.67 7.2×10 5 ˂ ER ≤ 7.6×10 5 1.99 2.62 1.00 5.55 7.6×10 5 ˂ ER ≤ 8.0×10 5 1.49 1.57 1.00 5.00 8.0×10 5 ˂ ER ≤ 8.4×10 5 1.49 1.05 1.00 4.44 8.4×10 5 ˂ ER ≤ 8.8×10 5 1.00 2.09 0.50 2.78 8.8×10 5 ˂ ER ≤ 9.2×10 5 1.00 0.52 1.00 1.67 9.2×10 5 ˂ ER ≤ 9.6×10 5 0.00 1.05 0.50 2.78 9.6×10 5 ˂ ER ≤ 1.0×10 6 1.00 0.52 0.50 2.22 1.0×10 6 Fig.9 and Table 3, it could be found that the f-value of the MBE device was the largest, and the f-value of the MFSE device was the smallest. That meant the electric field distribution of the MBE device was the most non-uniform due to the influence of the polymer nozzle, which caused the multiple jets generated mainly on the top of the bubble produced by the nozzle and near the top edge of the copper reservoir, as shown in Fig.3(a).…”

Section: Er (V/m)mentioning

confidence: 99%

“…Due to their excellent properties, such as high surface-to-volume ratios and high porosities, nanomaterials have become more and more important in industrial manufacturing. As one of the most important methods for preparing nanomaterials, electrospinning (ES) [1][2][3] has been receiving much attention [4][5][6][7]. But with the advancement of nanotechnology and the increasing performance requirements of nanomaterials, the fatal shortcoming of the traditional ES process, low yield [8,9], has received more attention.…”

Section: Introductionmentioning

confidence: 99%

Four self-made free surface electrospinning devices for high-throughput preparation of quality nanofibers

Fang¹,

Xu²

2019

Preprint

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Four different self-made free surface electrospinning (FSE) devices, namely, modified bubble-electorspinning (MBE) device, modified free surface electorspinning (MFSE) device, oblique section free surface electorspinning (OSFSE) device and spherical section free surface electrospinning (SSFSE) device, were presented to obtain high-throughput preparation of high quality nanofibers in this paper. The preparation mechanisms of these four FSE device were studied by simulating the electric field distribution using Maxwell 3D, due to the importance of electric field in the FSE process. And the effects of them on the morphology and yield of nanofibers were investigated by experiments. The experimental data agreed with the simulation results of electric field, and showed these four FSE device all could be used to prepare high quality nanofibers in large quantities. Meanwhile, comparing the spinning effects of these four FSE device, the results illustrated the SSFSE device was the optimal FSE device because of the highest quality and yield of nanofibers, and its yield could reach 20.03 g/h at the applied voltage of 40 kV.

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New Polymers for Needleless Electrospinning from Low-Toxic Solvents

Cited by 47 publications

References 36 publications

Sterilization of PAN/Gelatine Nanofibrous Mats for Cell Growth

Sterilization of PAN/Gelatine Nanofibrous Mats for Cell Growth

Electrospun Functional Materials toward Food Packaging Applications: A Review

Four self-made free surface electrospinning devices for high-throughput preparation of quality nanofibers

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