New Polyolefin Foil for 5-Day Storage of Platelet Concentrates (PC) Collected by Apheresis

Kretschmer, V.; Marschall, R; Schulzki, T.; Härtel, B; Neumann, H J

doi:10.1159/000222605

Cited by 2 publications

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“…The sample bags as well as the storage bags of both producers consisted of polyolefin foil 0.25 mm ('KonzentratMusterbeutel'; Fresenius AG) and 0.35 mm ('Lifecell'; Baxter GmbH). A study comparing the polyolefin storage bags used in both apheresis systems determined the following results: No significant differences concerning morphology, function, and platelet count between both storage bags were noted, but at the 5th day of storage a significantly higher pCO2 value and a significantly lower pH was found in the storage bags of Fresenius [30]. All PC in this study were separated with the AS 104 machine, suggesting an influence of the apheresis procedure on platelet loss.…”

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confidence: 59%

Platelet Function in Platelet Concentrates during Storage: Comparison of Two Blood Cell Separators

Latza¹,

Koscielny²,

Radtke³

et al. 2000

Transfus Med Hemother

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Background: In a controlled, randomized, prospective, open, comparative study we evaluated the platelet function of 112 platelet concentrates (PC) prepared by apheresis during 5-day storage. Material and Methods: In one group, 56 PC were prepared by blood cell separator CS-3000 Plus (Baxter GmbH) and the collecting chamber PLT 30^™ with the Omnix^™ system; in the second group, 56 PC were prepared by blood cell separator AS-104 (Fresenius AG). In order to assess the platelet function of PC, the following parameters have been investigated at the day of donation and after 48-hour and 120-hour storage: platelet reactivity according to the Grotemeyer method, index of platelet aggregation induced by ADP and collagen, respectively, and platelet count. Results: Due to an elevated number of hyperaggregable platelets in PC separated with the CS-3000 Plus, platelet reactivity of PC in case of separation with the CS-3000 Plus was higher (1.46 ± 0.9) compared to that of PC separated with the AS-104 (1.20 ± 0.40; p = 0.064). The collagen-induced platelet aggregation after 48-hour storage was significantly higher in PC obtained by the AS-104 separator compared to that of the CS-3000 Plus device (1.54 ± 0.36 versus 1.45 ± 0.36; p < 0.018). With an increase of 63.7%, the level of ADP-induced aggregation was higher in PC collected with the AS-104 than that found in PC obtained by the CS-3000 Plus (34.3%; p = 0.018). With both methods, ADP-induced aggregation only occurred on the day of donation. In PC prepared by AS-104, the reduction of platelets during 5-day storage was 133 × 10³/μl (11%) compared with 294 × 10³/μl (21%) in PC generated by the CS-3000 Plus. The volume of PC showed also differences between the two methods. Conclusion: This investigation demonstrates the necessity to define quality characteristics for PC regarding platelet function in order to optimize the separation process.

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confidence: 59%

Platelet Function in Platelet Concentrates during Storage: Comparison of Two Blood Cell Separators

Latza¹,

Koscielny²,

Radtke³

et al. 2000

Transfus Med Hemother

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“…For the storage of red blood cells, an alternative plasticizer such as butyryl-trihexyl-citrate (BTHC) or di-iso-nonyl-1, 2-cyclohexanedicarboxylate (DINCH) is used. Polyolefins as alternative polymers are used to store platelets [55,56]. Polyethylene and polyurethanes are used to create tubes.…”

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confidence: 99%

Biopolymers for Biomedical and Pharmaceutical Applications: Recent Advances and Overview of Alginate Electrospinning

et al. 2019

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Innovative solutions using biopolymer-based materials made of several constituents seems to be particularly attractive for packaging in biomedical and pharmaceutical applications. In this direction, some progress has been made in extending use of the electrospinning process towards fiber formation based on biopolymers and organic compounds for the preparation of novel packaging materials. Electrospinning can be used to create nanofiber mats characterized by high purity of the material, which can be used to create active and modern biomedical and pharmaceutical packaging. Intelligent medical and biomedical packaging with the use of polymers is a broadly and rapidly growing field of interest for industries and academia. Among various polymers, alginate has found many applications in the food sector, biomedicine, and packaging. For example, in drug delivery systems, a mesh made of nanofibres produced by the electrospinning method is highly desired. Electrospinning for biomedicine is based on the use of biopolymers and natural substances, along with the combination of drugs (such as naproxen, sulfikoxazol) and essential oils with antibacterial properties (such as tocopherol, eugenol). This is a striking method due to the ability of producing nanoscale materials and structures of exceptional quality, allowing the substances to be encapsulated and the drugs/ biologically active substances placed on polymer nanofibers. So, in this article we briefly summarize the recent advances on electrospinning of biopolymers with particular emphasis on usage of Alginate for biomedical and pharmaceutical applications.

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New Polyolefin Foil for 5-Day Storage of Platelet Concentrates (PC) Collected by Apheresis

Cited by 2 publications

References 0 publications

Platelet Function in Platelet Concentrates during Storage: Comparison of Two Blood Cell Separators

Platelet Function in Platelet Concentrates during Storage: Comparison of Two Blood Cell Separators

Biopolymers for Biomedical and Pharmaceutical Applications: Recent Advances and Overview of Alginate Electrospinning

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