New polyurethane heart valve prosthesis: design, manufacture and evaluation

Mackay, Tom G.; Wheatley, David J.; Bernacca, G M; Fisher, A.C.; Hindle, C.S.

doi:10.1016/0142-9612(95)00242-1

Cited by 111 publications

(83 citation statements)

References 20 publications

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“…Hauen erabilera biomedikuntzan ugaria da: besteak beste, poliuretanozko bihotz artifizialak [5,6], poliakrilonitrilozko dialisirako mintzak [7], edo polimetilmetakrilatozko ukipen lenteak [8].…”

Section: Sarreraunclassified

Multigeruza polimerikoak: mediku-protesietarako materialen ezaugarriak hobetzeko bidea

Valverde

Pérez‐Álvarez

2018

EKAIA

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Laburpena: Biomedikuntza arloan inplante moduan erabiltzeko material berrien eskaera handia dago, baina errefus arazoak sortzen dituzte biobateragarritasun kontuak direla eta.Lan honetan azalduko dugu nola eraldatu dugun bi substratu motaren gainazala. Bat ezorganikoa izango da eta bestea polimerikoa. Geruzaz geruzako («layer by layer») estrategiaz baliatuta, azido hialuroniko eta kitosanozko multigeruzak sortuko dira.Kitosanoa fluoreszenteki markatu eta mikroskopio konfokalean fluoreszentziahaz kun dea behatu ondoren, ondorioztatu da geruzak modu arrakastatsu batean sortu direla. Honi esker, materialaren hidrofilitatea areagotzea lortu da, eta horrela, bakterioen aurkako gainazala lortzeaz gainera materialaren biobateragarritasuna handituko da modu merke eta sinple batean.Hitz gakoak: Geruzaz geruzako, biobateragarri, kitosanoa, azido hialuronikoa.Abstract: There is a great demand for new materials in the field of biomedicine to be used as implants, however they cause rejection problems due to their lack of biocompatibility. In this work two substrates (inorganic and polymeric) will be surface modified using the layer by layer strategy (LbL), in order to construct hyaluronic and chitosan multilayers. It has been proven that the layers were successfully built by fluorescent confocal microscopy by means of the increase of fluorescence along layers deposition after fluorescent labelling of chitosan. Thanks to this, it has been possible to increase the hydrophilicity of the surfaces enhancing antibacterial properties and getting more biocompatible materials in a simple and inexpensive way.

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Section: Sarreraunclassified

Multigeruza polimerikoak: mediku-protesietarako materialen ezaugarriak hobetzeko bidea

Valverde

Pérez‐Álvarez

2018

EKAIA

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“…The promising approaches are the seeding of decellularized porcine or human heart valves and the application of synthetic materials such as polyurethane as scaffold materials. [11][12][13] Seeding is most frequently achieved using vascular or stem cells 14,15 Seeding scaffolds with autologous cells has the advantage of thrombogenicity and immunogenicity when implanted. 16 Decellularization success and seeding efficiency must be visualized in an attempt to develop quality control in tissue engineering.…”

mentioning

confidence: 99%

Non-Invasive analysis of synthetic and decellularized scaffolds for heart valve tissue engineering

Akra¹,

Haller²,

Thierfelder³

et al. 2012

Thorac cardiovasc Surg

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Microcomputed tomography (µ-CT) is a nondestructive, highresolution, three-dimensional method of analyzing objects. The aim of this study was to evaluate the feasibility of using µ-CT as a noninvasive method of evaluation for tissue-engineering applications. The polyurethane aortic heart valve scaffold was produced using a spraying technique. Cryopreserved/thawed homograft and biological heart valve were decellularized using a detergent mixture. Human endothelial cells and fibroblasts were derived from saphenous vein segments and were verified by immunocytochemistry. Heart valves were initially seeded with fibroblasts followed by colonization with endothelial cells. Scaffolds were scanned by a µ-CT scanner before and after decellularization as well as after cell seeding. Successful colonization was additionally determined by scanning electron microscopy (SEM) and immunohistochemistry (IHC). Microcomputed tomography accurately visualized the complex geometry of heart valves. Moreover, an increase in the total volume and wall thickness as well as a decrease in total surface was demonstrated after seeding. A confluent cell distribution on the heart valves after seeding was confirmed by SEM and IHC. We conclude that µ-CT is a new promising noninvasive method for qualitative and quantitative analysis of tissueengineering processes. ASAIO Journal 2013;59:169-177.

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“…Polymer trileaflet heart valves have been under investigation since the 1960's, but they have met with limited success due to poor material and design choices [4][5][6][22][23][24][25][26][27][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

“…Bernacca, Mackay, Wheatley, and colleagues have concentrated their efforts on polyurethane for trileaflet heart valves, but their results revealed that calcification, lack of durability, and thrombus formation were still existent problems preventing the success of these valves [4,22,23,24,26]. In addition to these findings, biodegradation of polyurethanes in vivo has been a persistent problem [24,27].…”

Section: Polymer Trileaflet Valvesmentioning

confidence: 99%

“…As was evident in many polyurethane prostheses, calcium accumulates in regions of high stress concentrations and surface defects, so mechanical degradation can act as a precursor to calcification [23]. It is hypothesized that by closely mimicking the natural valve's transvalvular flow pattern, one can produce a valve with increased durability and reduced incidence of thrombosis.…”

Section: Polymer Trileaflet Valvesmentioning

confidence: 99%

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Durability Assessment of Polymer Trileaflet Heart Valves

Gallocher¹

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New polyurethane heart valve prosthesis: design, manufacture and evaluation

Cited by 111 publications

References 20 publications

Multigeruza polimerikoak: mediku-protesietarako materialen ezaugarriak hobetzeko bidea

Multigeruza polimerikoak: mediku-protesietarako materialen ezaugarriak hobetzeko bidea

Non-Invasive analysis of synthetic and decellularized scaffolds for heart valve tissue engineering

Durability Assessment of Polymer Trileaflet Heart Valves

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