New Predictor of Atherosclerosis in Subjects With COPD: Atherogenic Indices

Abstract

We concluded that atherogenic indices (atherogenic index of plasma, cardiogenic risk ratio, atherogenic coefficient) could be considered as a useful predictor for atherosclerosis and cardiovascular diseases in stable COPD patients. Nevertheless, further prospective investigations on this issue are warranted.

Association between chronic obstructive pulmonary disease and serum lipid levels: a meta-analysis

“…The characteristics of the included studies are summarized in Table 1 . The publication dates of the 11 included studies ranged from 1981 to 2018 [ 13 – 23 ]. The included studies had been performed in Turkey, Bangladesh, China, Canada, Italy, United States, and India.…”

“…Dyslipidemia is an important component of the metabolic syndrome and is included in definitions of the metabolic syndrome published by different international committees [ 24 ]. Several studies have evaluated the relationship between COPD and blood lipid profiles, but the results remain controversial [ 13 , 14 , 17 , 19 ]. In this meta-analysis, we compared the serum levels of HDL, LDL, TC, and TG between the COPD and healthy control groups.…”

“…The reported associations of blood lipid profiles with COPD have been reported as positive, negative, or no association. Sibel et al found that serum HDL level was significantly lower, while TG level was significantly higher in subjects with stable COPD than in control subjects [ 13 ]. Jiayu et al reported that there was no difference between serum TG, TC, and LDL levels of COPD patients and control individuals [ 14 ].…”

“…A number of studies have evaluated the relationship between COPD and blood lipid profiles with inconsistent results. While some authors reported reduced serum levels of HDL or increased serum levels of TG in COPD patients [ 13 , 14 ], others did not observe any significant changes in lipid serum profiles [ 15 ]. The objective of the present study was to investigate the association between COPD and the serum levels of HDL, LDL, total cholesterol (TC), and TG.…”

Predictors for development of major cardiovascular events in elderly patients with severe and extremely severe chronic obstructive pulmonary disease in combination with early stages of chronic kidney disease

“…Показатели липидного спектра, формирующие значимую часть суммы баллов у пациентов с тяжелым и крайне тяжелым течением ХОБЛ, в нашей работе имеют относительно невысокие значения. Согласно современным данным, в ходе формирования уровня липидов, помимо диетических особенностей, определенную роль играет системное воспаление, характерное для ХОБЛ, что приводит к снижению показателей ЛПВП, принимающих участие в нивелировании воздействия бактериальных и вирусных агентов, что подтверждается в ряде работ полученной отрицательной связью с маркерами воспаления [18][19][20]. Подобные данные согласуются с результатами нашего исследования, в котором выявлена отрицательная корреляция средней силы между показателями ЛПВП и значением СРБ (r=0,79, p=0,003).…”