New pregnane glycosides from Caralluma negevensis

Braca, Alessandra; Bader, Ammar; Morelli, Ivano; Scarpato, Roberto; Turchi, G.; Pìzza, Cosimo; Tommasi, Nunziatina De

doi:10.1016/s0040-4020(02)00563-x

Cited by 40 publications

(36 citation statements)

References 13 publications

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“…In these molecules, the sugar moiety is mostly linked at the C-3 position of the aglycone and generally occurs as a linear rather than a branched oligosaccharide chain (Panda et al, 2006). In recent years, several studies have reported that pregnane glycosides have considerable bioactivity, including compounds with antiproliferative (Cioffi et al, 2006;Plaza et al, 2005), cytotoxic (Braca et al, 2002;De Leo et al, 2005;Chen et al, 2010;Waheeda et al, 2011;Al-Massarani et al, 2012), antifungal (Yoon et al, 2011) and antidepressant (Yang et al, 2011) activities.…”

Section: Introductionmentioning

confidence: 99%

Pregnane-type steroidal glycosides from Gymnema griffithii Craib.

2014

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Section: Introductionmentioning

confidence: 99%

Pregnane-type steroidal glycosides from Gymnema griffithii Craib.

2014

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“…Compounds 7 and 8 were purified from the aerial parts of Periploca graeca L. (Asclepiadaceae) and their structures were elucidated by 1D‐ and 2D‐NMR experiments 18. Compounds 9 – 11 were isolated from the whole plant of Caralluma negevensis Zohary (Asclepiadaceae) and identified by spectroscopic techniques, as reported in our previous paper 19. Purity of all the investigated compounds was verified by LC/MS and NMR spectroscopy.…”

Section: Methodsmentioning

confidence: 88%

“…The structures of all the analyzed compounds, together with their molecular masses, are shown in Fig. 1; compounds 1 – 6 were sourced commercially and are ginsenosides, triterpenoid saponins constituting the main bioactive ingredients of Panax ginseng ,20 whereas compounds 7 – 11 are steroidal glycosides purified from different plant extracts 18, 19…”

Section: Resultsmentioning

confidence: 99%

Intramolecular interchain reactions in bidesmosidic glycosides, a new insight into carbohydrate rearrangements induced by electrospray ionisation

Piaz

Leo

Braca

et al. 2007

Rapid Comm Mass Spectrometry

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Glycoconjugates are a class of complex molecules that are widely distributed in the plant kingdom and in some marine organisms. This class of compounds has a wide range of biological activities such as anti-inflammatory, antimicrobial, antifungal, anticancer, antiulcer, and immunoenhancing actions.1-3 Some of them also show various toxic activities such as cytotoxic, hemolytic, cardiotoxic, and teratogenic. Among these compounds, steroidal and triterpenoid saponins have long been known as components of widely used herbal drugs and pharmaceutical preparations; ginseng, Tribulus terrestris, Quillaja saponaria, and Digitalis ssp. are just a few examples. Thus, identification of saponins in herbal drugs used worldwide is of significance in phytochemical and toxicological quality control studies, and for the production of safe health products. Therefore, there is continuing demand for methods to rapidly identify and characterize these natural products.

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“…Several species of the genus Caralluma are rich in pregnane glycosides, flavone and megastigmane glycosides, and various esters, which authenticate its medicinal importance [7–9]. Antioxidant, anticancer, antidiabetic, anti‐inflamatory, antimicrobial, anti‐eczemic, antimalarial and antifungal properties of various Caralluma extracts showed its pharmacological importance [10,11].…”

Section: Introductionmentioning

confidence: 99%

A review on ethnobotany, phytochemistry and pharmacology of plant genus C aralluma R. Br

Adnan

Jan

Mussarat

et al. 2014

Journal of Pharmacy and Pharmacology

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Objectives Caralluma is a xerophytic genus used as traditional medicine for the treatment of diabetes, inflammation, leprosy, obesity and rheumatism. Objectives of this review are to establish a relationship between traditional uses and scientific studies by critically evaluating the available fragmented literature on ethnobotany, pharmacology, phytochemistry and toxicology of genus Caralluma. Key findings Ethnomedical uses of Caralluma have been recorded from various countries such as China, India, Iran and Pakistan for six major classes of diseases including diabetes and gastrointestinal disorders. This review indicated the efficacy of genus Caralluma in several in vitro and in vivo pharmacological properties such as antimicrobial, antioxidant and anticancer activity. These bioactivity might be due to the presence of certain classes of compounds in genus Caralluma including pregnane glycosides, flavonoid glycosides and flavones. Summary Traditional uses and scientific evaluation of Caralluma indicates that it is one of the most widely used genus in some parts of the world. Further studies on the structural activity relationship of some of the isolated compound may improve their biological potency as well as scientific exploitation of traditional uses of the genus.

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New pregnane glycosides from Caralluma negevensis

Cited by 40 publications

References 13 publications

Pregnane-type steroidal glycosides from Gymnema griffithii Craib.

Pregnane-type steroidal glycosides from Gymnema griffithii Craib.

Intramolecular interchain reactions in bidesmosidic glycosides, a new insight into carbohydrate rearrangements induced by electrospray ionisation

A review on ethnobotany, phytochemistry and pharmacology of plant genus C aralluma R. Br

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