New Progress regarding the Use of Lactic Acid Bacteria as Live Delivery Vectors, Treatment of Diseases and Induction of Immune Responses in Different Host Species Focusing on <i>Lactobacillus</i> Species

Abstract

Lactobacillus species are non-spore-forming, gram-positive bacteria and lactic acid producing bacteria (LAPB) that naturally inhabit the human and animal gastrointestinal and mouth organs. The aim of this review was to evaluate the How to cite this paper49 World Journal of Vaccines in the Th17 cells was tremendously appropriate finding because demonstrated that levels of these cells were regulated by gut-intrinsic mechanisms that generate pro-inflammatory cytokines for instance TGF-β1, TNF-α, IL-1β and IL-6 [71] [72] [73]. Oral administration of recombinant Lactobacillus plantarum NC8 considerably decreased systolic blood pressure, increased level of nitric oxide, as well as decreased levels of endothelin and AngII in plasma, heart, and kidney, representing the potential application of recombinant Lactobacillus plantarum in the treatment of hypertension [69]. In additional; an oral, genetically-modified strain of the probiotic Lactobacillus was used to treat rats with high blood pressure in the lungs, which resulted in improved heart contractility, reduced blood pressure, and reduced heart wall thickness. Also researchers genetically engineered strains of Lactobacillus species, to express and secrete Ang-(1-7), tested in an animal study and was effectively treat pulmonary hypertension [69]. Fermented whey S. M. Shonyela et al.