New promising<i>Euphorbiaceae</i>extracts with activity in human lymphocytes from primary cell cultures

Llanes-Coronel, Doris S.; Gámez-Díaz, Laura; Suarez-Quintero, Leidy P.; Páez, Lady J.; Torres, Fernando; Echeverri, Fernándo; Ponte-Sucre, Alicia; Patiño, Pablo Javier; Trujillo-Vargas, Claudia M.

doi:10.3109/08923973.2010.502173

Cited by 16 publications

(8 citation statements)

References 26 publications

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“…This result is in contrast to what reported by literature for PBMCs treated with E. tirucalli [34], which seems to result in an increased proliferation rate following treatment. Quite interestingly, we were not able to reproduce these results neither in LCLs or cord-blood-derived cells.…”

Section: Discussioncontrasting

confidence: 99%

“…Quite interestingly, we were not able to reproduce these results neither in LCLs or cord-blood-derived cells. One possible explanation could be that the increase of cell proliferation previously reported [34] has been observed mostly on the CD3 + subpopulation within PBMC, which represents lymphoid T-cells, whereas our results are referred to EBV-infected B-cells.…”

Section: Discussionmentioning

confidence: 69%

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EBV Reactivation and Chromosomal Polysomies:Euphorbia tirucallias a Possible Cofactor in Endemic Burkitt Lymphoma

Mannucci

Luzzi

Carugi

et al. 2012

Advances in Hematology

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Burkitt lymphoma is endemic in the Equatorial Belt of Africa, its molecular hallmark is an activated,MYCgene mostly due to a chromosomal translocation. Especially in its endemic clinical variant, Burkitt lymphoma is associated with the oncogenic Epstein-Barr virus (EBV), and holoendemic malaria acts as an amplifier. Environmental factors may also cooperate in Burkitt lymphomagenesis in the endemic regions, such as plants used as traditional herbal remedies.Euphorbia tirucalli, a plant known to possess EBV-activating substances, has a similar geographical distribution to endemic Burkitt’s Lymphoma and is used as a hedge, herbal remedy and toy in the Lymphoma BeltI. In this study we aimed at determining if exposure toEuphorbia tirucallicould contribute to lymphomagenesis, and at which extent. Lymphoblastoid and cord blood-derived cell lines were treated with plant extracts, and the expression of EBV-coded proteins was checked, to assess EBV reactivation. The occurrence of chromosomal translocations was then investigated by FISH. Our preliminary results suggest thatE. tirucalliis able to reactivate EBV and determine chromosomal alterations, which leads to c-MYC altered expression. The existence of genomic alterations might determine the accumulation of further genetic alteration, which could eventually lead to a transformed phenotype.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 69%

EBV Reactivation and Chromosomal Polysomies:Euphorbia tirucallias a Possible Cofactor in Endemic Burkitt Lymphoma

Mannucci

Luzzi

Carugi

et al. 2012

Advances in Hematology

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“…Furthermore, the presence of phenolic compounds or terpenoids may be related to this antiproliferative activity [35, 41, 42]. Based on the antioxidant results, the proliferative or antiproliferative effects of P. volubilis extracts on different cell lines (normal cells: 3T3 and CHO; tumor cells: HeLa and A549) were analyzed.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant and Antiproliferative Activities of Leaf Extracts fromPlukenetia volubilisLinneo (Euphorbiaceae)

Nascimento

Melo-Silveira

Dantas-Santos

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Plukenetia volubilis Linneo, or Sacha inca, is an oleaginous plant from the Euphorbiaceae family. The aim of this work was to perform a chemical and biological analysis of different leaf extracts from P. volubilis such as aqueous extract (AEL), methanol (MEL), ethanol (EEL), chloroform (CEL), and hexane (HEL). Thin layer chromatography analysis revealed the presence of phenolic compounds, steroids, and/or terpenoídes. Furthermore, the antioxidant activities were analyzed by in vitro assays and their effects on cell lineages by in vivo assays. The Total Antioxidant Capacity (TCA) was expressed as equivalent ascorbic acid (EEA/g) and it was observed that the extracts showed values ranging from 59.31 to 97.76 EAA/g. Furthermore, the DPPH assay values ranged from 62.8% to 88.3%. The cell viability assay showed that the extracts were able to reduce viability from cancer cells such as HeLa and A549 cells. The extracts MEL and HEL (250 µg/mL) were able to reduce the proliferation of HeLa cells up to 54.3% and 48.5%, respectively. The flow cytometer results showed that these extracts induce cell death via the apoptosis pathway. On the other hand, the extracts HEL and AEL were able to induce cell proliferation of normal fibroblast 3T3 cells.

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“…-Process by variant [7][8][9][10][11]; -Generative or semi-generative process [7][8][9]12] comprising:…”

Section: Problem Statementmentioning

confidence: 99%

Decision-making for multi-criteria optimization of process planning

Delolme

Antomarchi

Durieux

et al. 2019

Mechanics & Industry

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The objective of this work is to develop a methodology for the automatic generation of optimised and innovative machining process planning that enable aeronautical subcontractors to face current productivity and competitiveness issues. A four-step methodology is proposed, allowing the user to obtain optimised machining ranges that respect his know-how and experience and introduce innovation. This methodology is based on a representation of the decisional behaviour of the user in a given situation as well as in the face of the risk of industrialisation and broadens the formalisation of the performance of a process by taking into account other performance criteria other than machining time or overall cost. A genetic algorithm is used to generate optimized process planning. An AHP method is used to represent the decision-making process. The methodology presents the best processes generated and the use of social choice theory enables it to target the most efficient ranges to be implemented, by integrating a risk criterion to the industrialization.

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New promisingEuphorbiaceaeextracts with activity in human lymphocytes from primary cell cultures

Abstract: Altogether, these results reveal the presence of novel candidates within the Euphorbia plants to induce proliferation and apoptosis in human lymphocytes, mainly in CD3(+) T cells.

Cited by 16 publications

References 26 publications

EBV Reactivation and Chromosomal Polysomies:Euphorbia tirucallias a Possible Cofactor in Endemic Burkitt Lymphoma

EBV Reactivation and Chromosomal Polysomies:Euphorbia tirucallias a Possible Cofactor in Endemic Burkitt Lymphoma

Antioxidant and Antiproliferative Activities of Leaf Extracts fromPlukenetia volubilisLinneo (Euphorbiaceae)

Decision-making for multi-criteria optimization of process planning

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