New prospects of cancer therapy based on pyroptosis and pyroptosis inducers

Chen, Qiaoyun; Sun, Yuxiang; Wang, Siliang; Xu, Jingyan

doi:10.1007/s10495-023-01906-5

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2024

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Cited by 4 publications

(1 citation statement)

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“…, photo, electromagnetic, and ultrasound)-activated systems would provide spatiotemporal controllable methods to stimulate precise drug activation at the target site. 63,64…”

Section: Discussionmentioning

confidence: 99%

Metal–organic framework (MOF)-based materials for pyroptosis-mediated cancer therapy

Dou,

Wang,

Tian

et al. 2024

Chem. Commun.

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“…, photo, electromagnetic, and ultrasound)-activated systems would provide spatiotemporal controllable methods to stimulate precise drug activation at the target site. 63,64…”

Section: Discussionmentioning

confidence: 99%

Metal–organic framework (MOF)-based materials for pyroptosis-mediated cancer therapy

Dou,

Wang,

Tian

et al. 2024

Chem. Commun.

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Apoptosis‐Sensitizing Tumor Nanomedicine by Regulating Pyroptosis‐Associated Inflammatory Cell Death

Du,

Zhao,

Song

et al. 2024

Adv Funct Materials

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The vigorous development of cancer nanomedicine has revolutionized traditional oncology medicine, but it is also limited by the continuous mutation of cunning cancer cells, leading to apoptosis insensitivity and therapeutic disappointment. Inflammatory‐regulated cell death (RCD), especially pyroptosis‐related cell death, demonstrates huge potential for apoptosis sensitization due to its unique biochemical characteristics. The aim of this research is to present a thorough synopsis of the current knowledge on pyroptosis‐associated inflammatory cell death, including pyroptosis, cuproptosis, and PANoptosis, and the synergistic function in cancer nano therapy. Paradigm studies of pyroptosis‐related cell death‐mediated apoptosis‐sensitizing tumor nanotherapeutics are introduced in detail, and the coordination mechanisms based on nanomaterials are also discussed. In addition, multi‐angle analysis of the future prospects of pyroptosis‐sensitized tumor nanomedicine based on various nanomaterials is also emphasized to further expand the application scope of inflammatory RCD. It is believed that emerging auxiliary apoptosis‐sensitizing treatments based on inflammatory RCD will greatly promote the progress of cancer nanomedicine.

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Reuterin promotes pyroptosis in hepatocellular cancer cells through mtDNA-mediated STING activation and caspase 8 expression

Cui,

Xu,

Fan

et al. 2024

Cancer Letters

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New prospects of cancer therapy based on pyroptosis and pyroptosis inducers

Cited by 4 publications

References 195 publications

Metal–organic framework (MOF)-based materials for pyroptosis-mediated cancer therapy

Metal–organic framework (MOF)-based materials for pyroptosis-mediated cancer therapy

Apoptosis‐Sensitizing Tumor Nanomedicine by Regulating Pyroptosis‐Associated Inflammatory Cell Death

Reuterin promotes pyroptosis in hepatocellular cancer cells through mtDNA-mediated STING activation and caspase 8 expression

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