“…This effectively abolished the open sale of these substances by high street retailers (“head shops”) and was followed by a reduction in their use in the general population from 0.9% (279 000) in 2014-15 to 0.4% (130 000) in 2021-22 4. However, evidence is emerging that harms related to synthetic cannabinoids have not reduced but have shifted to more vulnerable groups , particularly people who are experiencing homelessness or are in prison 567. Alarmingly, deaths related to synthetic cannabinoids quadrupled after the act was introduced, according to data from the National Programme on Substance Abuse Deaths 7.…”