New pyrones and their analogs from the marine mangrove-derived Aspergillus sp. DM94 with antibacterial activity against Helicobacter pylori

Naphtho-γ-pyrone Dimers from an Endozoic Aspergillus niger and the Effects of Coisolated Monomers in Combination with Cisplatin on a Cisplatin-Resistant A549 Cell Line

“…After the 1D NMR and MS data of 2 – 8 were compared with literature data, it was revealed that these compounds possessed the same planar structures as those of asperpyrones B ( 2 ), asperpyrone D ( 3 ), asperpyrone C ( 4 ), asperpyrone A ( 5 ), , fonsecinone A ( 6 ), , dianhydro-aurasperone C ( 7 ), and aurasperone A ( 8 ), , respectively; this was confirmed by 2D NMR data. The Cotton effects of compounds 2 – 8 (as shown in Figure ) were similar to those in the CD spectrum of compound 1 , which indicated that the configuration of compounds 2 – 8 were a S ; among them, (a S )-asperpyrone C ( 4 ), (a S )-asperpyrone A ( 5 ), (a S )-fonsecinone A ( 6 ), and (a S )-aurasperone A ( 8 ) have been reported in pervious papers, and compounds 2 , 3 , and 7 were reported for the first time in this article, namely, (a S )-asperpyrones B ( 2 ), (a S )-asperpyrone D ( 3 ), and (a S )-dianhydro-aurasperone C ( 7 ), respectively.…”

“…Here, we report 20 polyketides isolated from this Aspergillus niger , including five new dimer naphtho-γ-pyrones ( 1 – 3 , 7 , and 9 ). Four known naphtho-γ-pyrone dimers, (a S )-asperpyrone C ( 4 ), (a S )-asperpyrone A ( 5 ), (a S )-fonsecinone A ( 6 ), and (a S )-aurasperone A ( 8 ), four naphtho-γ-pyrone monomers, TMC-256A1 ( 10 ), flavasperone ( 11 ), TMC-256C1 ( 12 ), and rubrofusarin B ( 13 ), and seven other polyketides, RF-3192C ( 14 ), pyranonigrin A, pyranonigrin S, aspergillusol, pyrophen, aspergyllone, and carbonarone A, were also isolated . The cytotoxicity of these compounds and their activity in combination with DDP were tested on A549 and A549/DDP cell lines, respectively.…”

Secondary metabolites from mangrove-associated fungi: source, chemistry and bioactivities

“…340 The other pyrone derivatives were obtained from two different mangrove endophytic fungal strains, such as two undescribed γ-pyrone derivatives fusolanones A ( 854 ) and B ( 855 ) from Fusarium strain, 341 and a pyrano[2,3- b ]pyrrole 856 from Aspergillus strain. 342…”

“…340 The other pyrone derivatives were obtained from two different mangrove endophytic fungal strains, such as two undescribed g-pyrone derivatives fusolanones A (854) and B (855) from Fusarium strain, 341 and a pyrano[2,3-b]pyrrole 856 from Aspergillus strain. 342 A Diaporthe strain yielded four unusual 2,3-dihydro-1Hindene isomers, diaporindenes A-D (857-860), possessing an unprecedented chemical skeleton featuring a 2,3-dihydro-1Hindene ring and a 1,4-benzodioxan moiety and showing significant inhibitory effects against nitric oxide production (NO) with IC 50 values from 4.2 to 8.5 mM. 164 One new antibacterial pentenoic acid derivative 861 was obtained from the Cladosporium strain.…”

Isolation and Characterization of Anti‐Inflammatory Sorbicillinoids from the Mangrove‐Derived Fungus Penicillium sp. DM815

“…We have long been interested in searching for new bioactive metabolites derived from marine and terrestrial microorganisms [11,12] . We have recently acquired a fungus strain Penicillium sp.…”