New radioiodinated methyl-branched fatty acids for cardiac studies

Knapp, F. F.; Ambrose, K.R.; Goodman, Mark M.

doi:10.1007/bf00258103

Cited by 142 publications

(51 citation statements)

References 4 publications

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“…3,4) Recently, BMIPP SPECT has been developed as a probe that enables the delineation of regional fatty-acid metabolic abnormalities of the myocardium. 5,6) In some patients with acute myocardial infarction, discrepant areas, which were documented by degrees of BMIPP and Tl defective images, were seen. [7][8][9] These discrepancies are thought to be good predictors of wall motion improvement in the convalescent stage.…”

mentioning

confidence: 99%

Usefulness of BMIPP SPECT to Evaluate Myocardial Viability, Contractile Reserve and Coronary Stenotic Progression after Reperfusion in Acute Myocardial Infarction.

et al. 2001

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SUMMARYUsing combined 123 I-BMIPP (BMIPP), 201 Tl (Tl) and 99m Tc-PYP (PYP) myocardial SPECT imaging, risk areas of acute myocardial infarction were documented in the acute stage, and then these images were evaluated for how well they reflected muscle viability, contractile reserve and coronary stenotic progression subsequent to reperfusion therapy. Patients who only experienced a first attack of myocardial infarction were enrolled. In total, 36 cases who had had the occluded artery successfully reperfused were examined during the past year. They had no significant vessel disease except for the culprit single artery. The patients were comprised of 32 men and 4 women. The mean age was 59.5 years. All patients underwent coronary angiography and left ventricular (LV) angiography in the emergency room. BMIPP/Tl and PYP myocardial SPECT were conducted in the acute stage and chronic stage. In the chronic stage LV angiography was repeated to assess the improvement of LV wall motion. The response to postextrasystolic potentiation (PESP) testing was performed to estimate myocardial contractile reserve. The risk area of acute myocardial infarction (AMI) was documented by reduced BMIPP accumulation. The size of reduced BMIPP accumulation was larger than that of PYP accumulation. A BMIPP/Tl discrepancy and PYP accumulation were documented to assess myocardial viability. Both improvement in LV wall motion and augmentation of PESP response were more closely related to a BMIPP/Tl discrepancy in the presence or absence of PYP accumulation. Therefore, it would be possible to evaluate myocardial viability and contractile reserve by the BMIPP/Tl discrepancy. In patients with good viability, it is important to predict whether there is coronary stenotic progression or not. In this study, we demonstrated that most patients with improved BMIPP images had no significant progression at the site of intervention. Serial observation of BMIPP images from the acute stage to the chronic stage might enable us to predict the progression of coronary stenosis. (Jpn Heart J 2001; 42: 435-449)

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mentioning

confidence: 99%

Usefulness of BMIPP SPECT to Evaluate Myocardial Viability, Contractile Reserve and Coronary Stenotic Progression after Reperfusion in Acute Myocardial Infarction.

et al. 2001

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“…BMIPP is an iodinated analog of pentadecanoic acid that is transported into the myocardium in a manner similar to that of LCFA, and it has therefore been proposed that BMIPP is useful as an LCFA probe for myocardial fatty acid metabolism. 11 …”

Section: Discussionmentioning

confidence: 99%

“…A dose of 111 MBq of BMIPP 11 (Nihon Medi-Physics Co, Ltd, Nishinomiya, Japan) was given intravenously at rest after at least 6-h of fasting. Anterior planar and single photon emission computed tomography images were obtained 15 min later.…”

Section: Bmipp Scintigraphymentioning

confidence: 99%

Influence of CD36 Deficiency on Heart Disease in Children

Teraguchi

Ikemoto

Unishi

et al. 2004

Circ J

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“…It is distributed in the myocardium according to regional blood flow and subsequently incorporated into the endogenous lipid pool in the myocardium. 16,17 Free fatty acid (FFA) is a major myocardial energy source involving β-oxidation after the tricarboxylic acid cycle in the basal oxygen state. The BMIPP is a methyl-branched fatty acid analogue-designed to resist β-oxidation.…”

Section: Kinetics Of ͵ͷͷ I-beta-methyl Iodophenyl Pentadecanoic Acidmentioning

confidence: 99%

Discrepancy between myocardial perfusion and fatty acid metabolism following acute myocardial infarction for evaluating the dysfunctional viable myocardium

Biswas

Sarai

Toyama

2012

Indian Heart Journal

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A B S T R A C TObjective: Following acute myocardial infarction (AMI) the area of myocardial perfusion and metabolism mismatch is designated as dysfunctional viable myocardium. 123I-beta-methyl iodophenyl pentadecanoic acid (BMIPP) is clinically very useful for evaluating myocardial fatty acid metabolism, and 99 mTc-Tetrofosmin (TF) is a widely used tracer for myocardial perfusion. This study was designed to evaluate the degree of discrepancy between BMIPP and TF at the subacute state of AMI.Methods: Fifty-two patients (aged 59 ± 10 years; mean 46 years) with AMI were enrolled, and all of them underwent percutaneous coronary intervention (PCI). Patients were classified according to ST-T change and PCI timing.123 I-beta-methyl iodophenyl pentadecanoic acid and TF cardiac scintigraphy were performed on 7 ± 3.5 days of admission using a dual headed gamma camera. Perfusion and fatty acid metabolism defect were scored on a 17 segments model. Results:The mean BMIPP defect score on early and delayed images were 16.67 ± 10.19 and 16.25 ± 10.40, respectively. The mean TF defect score was 10 ± 7.69. Defect score of BMIPP was significantly higher than that of the TF (P < 0.0001; 95% CI 4.32-7.02), and there was a strong correlation between perfusion and metabolism defect score (r = 0.89, P < 0.00001). Forty-seven (90%) patients showed mismatched defect (BMIPP > TF), and 5 (10%) patients showed matched defect (BMIPP = TF). Mismatched defect score (MMDS) was significantly higher in patients with ST-segment elevation myocardial infarction (STEMI) than that of non-ST-segment elevation myocardial infarction (NSTEMI) (P < 0.041; 95% CI 0.11-5.19). Conclusion:At the subacute state of AMI, most of the patients showed perfusion-metabolism mismatch, which represents the dysfunctional viable myocardium, and patients with STEMI showed higher mismatch.

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New radioiodinated methyl-branched fatty acids for cardiac studies

Cited by 142 publications

References 4 publications

Usefulness of BMIPP SPECT to Evaluate Myocardial Viability, Contractile Reserve and Coronary Stenotic Progression after Reperfusion in Acute Myocardial Infarction.

Usefulness of BMIPP SPECT to Evaluate Myocardial Viability, Contractile Reserve and Coronary Stenotic Progression after Reperfusion in Acute Myocardial Infarction.

Influence of CD36 Deficiency on Heart Disease in Children

Discrepancy between myocardial perfusion and fatty acid metabolism following acute myocardial infarction for evaluating the dysfunctional viable myocardium

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