New Rare Ent-Clerodane Diterpene Peroxides from Egyptian Mountain Tea (Qourtom) and Its Chemosystem as Herbal Remedies and Phytonutrients Agents

Abstract

Genus Stachys, the largest genera of the family Lamiaceae, and its species are frequently used as herbal teas due to their essential oils. Tubers of some Stachys species are also consumed as important nutrients for humans and animals due to their carbohydrate contents. Three new neo-clerodane diterpene peroxides, named stachaegyptin F-H (1, 2, and 4), together with two known compounds, stachysperoxide (3) and stachaegyptin A (5), were isolated from Stachys aegyptiaca aerial parts. Their structures were determined using a combination of spectroscopic techniques, including HR-FAB-MS and extensive 1D and 2D NMR (1H, 13C NMR, DEPT, 1H-1H COSY, HMQC, HMBC and NOESY) analyses. Additionally, a biosynthetic pathway for the isolated compounds (1–5) was discussed. The chemotaxonomic significance of the isolated diterpenoids of S. aegyptiaca in comparison to the previous reported ones from other Stachys species was also studied.

Genus Stachys: A Review of Traditional Uses, Phytochemistry and Bioactivity

“…A study conducted by Hegazy et al (2017) reported the discovery of three new neo -clerodane diterpenoids from the aerial parts of the aforementioned plant, namely stachaegyptins A-C ( 190 – 192 ) [ 106 ]. One year later, two new compounds were mentioned; stachaegyptins D-E ( 193 – 194 ) [ 131 ], while in a current work stachaegyptins F-H were isolated ( 195 – 197 ) [ 133 ]. Moreover, stachysperoxide ( 189 ) was isolated from the S. aegyptiaca [ 132 ].…”

Prediction of the taxonomical classification of theRanunculaceaefamily using a machine learning method

“…A large number of experimental results show that CHMs with similar substances have similar drug properties, and finally can be used to determine the multi-solvent similarity of hot and cold properties of Chinese herbal medicine components. Hussien et al 15 carried out chemo-systematic analysis on diterpenoid ingredients in various Stachys species, and proposed a unique biosynthetic pathway to generate neo-clerodane peroxides in S. aegyptiaca . However, few machine learning studies were associated with plant taxonomy to date, thus inspiring us to study plant taxonomy by machine learning.…”