In this paper we study the following hypergeometric polynomials: $$ \mathcal{P}_n(x) = \mathcal{P}_n(x;\alpha,\beta,\delta_1,
\dots,\delta_\rho,\kappa_1,\dots,\kappa_\rho) = $$ $$ = {}_{\rho+2} F_{\rho+1} (-n,n+\alpha+\beta+1,\delta_1+1,
\dots,\delta_\rho+1;\alpha+1,\kappa_1+\delta_1+1,
\dots,\kappa_\rho+\delta_\rho+1;x), $$ and $$ \mathcal{L}_n(x) = \mathcal{L}_n(x;\alpha,\delta_1,\dots,
\delta_\rho,\kappa_1,\dots,\kappa_\rho) = $$ $$ = {}_{\rho+1} F_{\rho+1} (-n,\delta_1+1,\dots,\delta_\rho+1;
\alpha+1,\kappa_1+\delta_1+1,\dots,\kappa_\rho+\delta_\rho+1;x),
\qquad n\in\mathbb{Z}_+, $$ where $\alpha,\beta,\delta_1,\dots,\delta_\rho\in(-1,+\infty)$, and $\kappa_1,\dots,\kappa_\rho\in\mathbb{Z}_+$, are some parameters. The natural number $\rho$ of the continuous parameters $\delta_1,\dots,\delta_\rho$ can be chosen arbitrarily large. It is seen that the special case $\kappa_1=\dots=\kappa_\rho=0$ leads to Jacobi and Laguerre orthogonal polynomials. Of course, such polynomials and more general ones appeared in the literature earlier. Our aim here is to show that polynomials $\mathcal{P}_n(x)$ and $\mathcal{L}_n(x)$ are Sobolev orthogonal polynomials on the real line with some explicit matrices of measures. The importance of the orthogonality property was our main reason to concentrate our attention on polynomials $\mathcal{P}_n(x)$ and $\mathcal{L}_n(x)$. Here we shall use some our tools developed earlier. In particular, it was shown recently that Sobolev orthogonal polynomials are related by a differential equation with orthogonal systems $\mathcal{A}$ of functions acting in the direct sums of usual $L^2_\mu$ spaces of square-summable (classes of the equivalence of) functions with respect to a positive measure $\mu$. The case of a unique $L^2_\mu$ is of a special interest, since it allows to use OPRL to obtain explicit systems of Sobolev orthogonal polynomials. The main problem here is \textit{to choose a suitable linear differential operator in order to get explicit representations for Sobolev orthogonal polynomials}. The proof of the orthogonality relations is then a verification of such a choice and it goes in another direction: we start from the already known polynomials to their properties. We also study briefly such properties of the above polynomials: integral representations, differential equations and location of zeros. A system of such polynomials with a kind of the bispectrality property is constructed.
