New research efficiency gel containing an extract of oak bark and extract of aloe under condition protamine periodontal

Tsubanova, N. A.; Hohlenkova, N. V.; Zhurenko, D. S.; Iroko, Imamuzo Mathew

doi:10.24959/ubphj.16.19

Cited by 2 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[15] The gel which contains an extract of oak bark and extract aloe, and Metrogyl Denta have effect on clinical parameters of experimental protamine periodontitis on the 7 th day of the experiment, as it shown in Figure 1. According to the results of the study, it is proved that on the 7 th day of the clinical manifestations of experimental protamine periodontitis acquired a significant effect.…”

Section: Resultsmentioning

confidence: 99%

Untitled

Tsubanova

2017

AJP

View full text Add to dashboard Cite

Introduction: Today in many countries, there is a clear trend to a growing number of major diseases of the oral cavity, due to the poor state of the environment, unbalanced diet, and concomitant chronic diseases of the gastrointestinal tract. Topical problem of modern medicine and pharmacy is optimization of pharmacotherapy of inflammatory periodontal diseases. The aim of the study was to establish optimal combination of new gel for the treatment of periodontal disease. Materials and Methods: The experimental studies were conducted on white male rats. Research of membrane protective activity was carried out on the standard model of spontaneous hemolysis of erythrocytes by Jager. The research of antimicrobial activity was carried out by method of diffusion in agar. Research of Parodont-protective effect was carried out on the model protamine periodontitis. Results and Discussions: Extract of Aloe has powerful membrane protective effect in different doses. The study in vitro showed the high sensitivity of thick oak bark extract in the form of a gel to the cultures of Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, and Candida аlbicans that allows to recommend it for the treatment of inflammatory diseases of the mouth. Conclusions: According to the results of screening studies, optimal composition of gel that contains Аloe arborescens and cortex Quercus were selected for the treatment of parodontal diseases. Parodont-protective activity of gel is confirmed on the protamine periodontitis model, the ability to decrease the clinical symptoms, namely, hyperemia, edema and necrotic erosive changes of the gums and mucous membranes of the mouth.

show abstract

Section: Resultsmentioning

confidence: 99%

Untitled

Tsubanova

2017

AJP

View full text Add to dashboard Cite

show abstract

Toxicological study of the new gel containing oak bark extract and aloe extract under long-term use

Zhurenko

Tsubanova

2019

Ukr. biopharm. j.

View full text Add to dashboard Cite

Toxicological study of the new gel containing oak bark extract and aloe extract under long-term use Topicality. The significant prevalence of destructive-inflammatory periodontal diseases and the imperfection of existing medicines determine the feasibility to develope new topical dosage forms with polymodal pharmacological activity and low toxicity. Scientists of NUPh developed a new gel, containing an oak bark extract and aloe extract with strong parodontoprotective effect. Aim. To study the toxicity of a new gel containing an oak bark extract and aloe extract under the long-term use. This new gel is developed by the scientists of NUPh, under the direction of prof. N. V. Khokhlenkova, and is intended for treatment of oral cavity inflammatory diseases. In previous studies a pronounced membran-protective, antimicrobial, anti-inflammatory activity and parodont-protective activity were established for the new gel. Materials and methods. Prior to the experiment, randomized samples were applied for the animal population taken in experimental groups and fixed averaged indicators of the initial state of animals organism. A new gel was applied on the skin. Results and discussion. Animals that received the new gel did not differ from the animals of the control groups in appearance, behavior and attitude to food. During the experiment, there were no signs of inhibition of activity and development of aggressiveness in animals of comparable groups. The results of the study of weight ratios of both sex rat organs indicate the absence of test gel toxic effects in doses of 0.5 and 5 ml. The new gel does does't reveal hepatotoxic effect. The results of lipid metabolism indices shows that there is no toxic effect in the studied doses. Conclusions. It was established that a new gel, containing oak bark extract and aloe extract, does not exert a toxic effect on the functions of vital organs and systems of the organism of experimental animals at the conditions of prolonged application (1 month) at doses of 0.5 ml and 5 ml. Along with the previously established parodontprotective, antimicrobial and other activities, the absence of toxic effects of a new gel under the conditions of long-term use is the basis for in-depth preclinical studies to create a new drug with parodontprotective effect.

show abstract

New research efficiency gel containing an extract of oak bark and extract of aloe under condition protamine periodontal

Cited by 2 publications

References 7 publications

Untitled

Untitled

Toxicological study of the new gel containing oak bark extract and aloe extract under long-term use

Contact Info

Product

Resources

About