New Results in Oligoribonucleotide Synthesis

Pfister, Magdalena; Pfleiderer, Wolfgang

doi:10.1080/07328318908054263

Cited by 10 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(5) Himmelsbach et al, 1984Pfleiderer et al, 1985Pfister and Pfleiderer, 1989 -Happ et al, 1987Hagen and Chládek, 1989Heikkilä and Chattopadhyaya, 1983Marugg et al, 1984Nagaich and Misra, 1989 4-nitrophenylethyloxycarbonyl Nyilas et al, 1988 G (N2); A (N6); C (N4) Brown et al, 1989Rao et al, 1987Tanimura et al, 1988Schaller et al, 1963Balgobin et al, 1981 Köster et al, 1981Sinha et al, 1993Boal et al, 1996 4-(tert-butyl)phenoxyacetyl diphenylacetyl 3,4-dichlorobenzoyl 3-methoxy-4-phenoxybenzoyl and removal of N-acyl protecting groups can also be achieved by enzymatic methods (Prasad and Wengel, 1996).…”

Section: Protection Of Exocyclic Amino Groupsmentioning

confidence: 99%

Nucleobase Protection of Deoxyribo‐ and Ribonucleosides

Meher

Iyer

2000

CP Nucleic Acid Chemistry

View full text Add to dashboard Cite

Protecting groups for the imide/lactam function of thymine/uracil and guanine, respectively, prevent irreversible nucleobase modifications that may occur in the presence of alkylating or condensing reagents that are commonly used in nucleoside protection and oligonucleotide synthesis. This unit reviews these protecting groups, and also identifies protecting groups for the exocyclic amino function of cytosine, adenine, and guanine. The unit also explores recent trends in nucleobase protection that permit reliable oligonucleotide synthesis and removal of N-protecting groups under very mild conditions.

show abstract

Section: Protection Of Exocyclic Amino Groupsmentioning

confidence: 99%

Nucleobase Protection of Deoxyribo‐ and Ribonucleosides

Meher

Iyer

2000

CP Nucleic Acid Chemistry

View full text Add to dashboard Cite

show abstract

Nucleobase Protection of Deoxyribo‐ and Ribonucleosides

Meher

Iyer

2017

CP Nucleic Acid Chemistry

View full text Add to dashboard Cite

Oligonucleotides carrying a variety of chemical modifications including conjugates are finding increasing applications in therapeutics, diagnostics, functional genomics, proteomics, and as research tools in chemical and molecular biology. The successful synthesis of oligonucleotides primarily depends on the use of appropriately protected nucleoside building blocks including the exocyclic amino groups of the nucleobases, the hydroxyl groups at the 2'-, 3'-, and 5'-positions of the sugar moieties, and the internucleotide phospho-linkage. This unit is a thoroughly revised update of the previously published version and describes the recent development of various protecting groups that facilitate reliable oligonucleotide synthesis. In addition, various protecting groups for the imide/lactam function of thymine/uracil and guanine, respectively, are described to prevent irreversible nucleobase modifications that may occur in the presence of reagents used in oligonucleotide synthesis. © 2017 by John Wiley & Sons, Inc.

show abstract

Dibasic amines as competitive ions improve the resolution between polyanionic nucleotides

Callahan

Schwartz

1991

Analytical Biochemistry

View full text Add to dashboard Cite

New Results in Oligoribonucleotide Synthesis

Cited by 10 publications

References 0 publications

Nucleobase Protection of Deoxyribo‐ and Ribonucleosides

Nucleobase Protection of Deoxyribo‐ and Ribonucleosides

Nucleobase Protection of Deoxyribo‐ and Ribonucleosides

Dibasic amines as competitive ions improve the resolution between polyanionic nucleotides

Contact Info

Product

Resources

About