“…Through the cell-cell contact with the MSCs, IL-6 confers contact-mediated drug resistance to the MMCs [7,8]. Other factors, such as Insulin-like Growth Factor 1 (IGF-1), Interleukin-1 (IL-1), Hepatocyte Growth Factor (HGF), TGF-𝛽, and Stromal cell-Derived Factor-1𝛼 (SDF-1𝛼), are reported to play an important role in MMCs growth, proliferation, and migration [6,12,13].…”