New ruthenium(ii) complexes with quinone diimine and substituted bipyridine as inert ligands: synthesis, characterization, mechanism of action, DNA/HSA binding affinity and cytotoxic activity

Abstract

Within this paper is presented the synthesis and structural characterization of the series of new ruthenium(II) complexes 1–7, with general formula mer-[RuL3(N-N)Cl]Cl, where L is 2,2′:6′,2′′-terpyridine (tpy) or 4'-(4-chlorophenyl)-2,2′:6′,2′′-terpyridine (Cl-Ph-tpy);...

Noncovalent interactions of antitumor cycloplatinated complexes containing trifluoroacetate ligands as the leaving group with bovine serum albumin. Implications for drug design

“…Tryptophan (Trp-134) and Trp-212 are two amino acid residues which are almost entirely responsible for the intrinsic emission of BSA protein. 54,55 As seen in Fig. 2, the corresponding emission peak was detected at 345 nm in aqueous buffer solution when excited at 280 nm.…”

“…Ibuprofen and warfarin have been considered as representative site indicator probes for site II and site I of BSA protein, respectively. 55 The associative binding constants values will be changed when Pt(II) complexes compete with site-marker probes, interacting at the same site. Hence, the fluorescence quenching titration at fixed 1 : 1 molar ratios of BSA-marker as a function of differing concentrations of 1 or 2 was investigated.…”

“…Ibuprofen and warfarin have been considered as representative site indicator probes for site II and site I of BSA protein, respectively. 55…”

Ruthenium(II) Polypyridyl Complexes with Benzoxazole Derivatives and Non‐Innocent Ligands as Effective Antioxidants in Human Neuroblasts

“…This coordination mode, which is in agreement with what generally reported for analogues ruthenium complexes with non‐innocent ligands prepared under similar experimental conditions, [33,34–36] has been confirmed by NMR and MS analysis. In fact, the positive‐ion electrospray mass (ESI MS) spectra of Ru1 displays the isotopic pattern of the mono positively charged species [Ru(dpby)(nqdi)Cl] + , centered at 634.5 (m/z=1) (Figures S8‐9, SI), whereas the two peaks at considerably high frequencies (13.78 and 12.22 ppm, each integrating 1H), in the 1 H NMR spectrum of Ru1 (Figure S4, SI) are typically attributable to imine protons [26,35] . Similar evidences have been recently reported for the reference compound Ru2 [26] …”

A Personal Account on Inorganic Reaction Mechanisms

“…Understanding the reactivity of Ru(II) polypyridyl complexes is important in terms of their potential biological applications in particular, anti-tumor activity [201][202][203][204][205][206][207] and their role in the redox biology of cells. [208][209][210][211] Such Ru(II) complexes are prodrugs that are activated via the aquation of the chloride ligand.…”