New Scalaranes from the Nudibranch <i>Glossodoris </i><i>atromarginata</i> and Its Sponge Prey

Fontana, Angelo; Cavaliere, Paolo; Ungur, Nicon; D'Souza, Lisette; Parameswaram, P. S.; Cimino, Guido

doi:10.1021/np9900932

Cited by 47 publications

(81 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Certain derivatives were also found in a nudibranch species, presumably via dietary accumulation [6]. Of particular interest among the scalaranes in this report is heteronemin (1).…”

Section: Introductionmentioning

confidence: 74%

“…collected from Koh-Tao, Surat-Thani Province, a minor scalarane derivative (6) was isolated from the hexane extract [10]. The structure determination of 6 was carried out by means of spectroscopic analysis to show that the compound, designated as 12-epideacetyl-19α-acetoxy-20α-methoxyscalaran [11], was a new member of the tetracarbocyclic sesterterpenes, possessing an attached dihydrofuran moiety with two acid-labile acetal carbons.…”

Section: A Minor Scalarane Derivativementioning

confidence: 99%

See 1 more Smart Citation

Structure-activity relationships of antitubercular scalaranes: Heteronemin revisited

Jaisamut

Thengyai

Yuenyongsawad

et al. 2009

Pure and Applied Chemistry

View full text Add to dashboard Cite

A series of heteronemin-related antitubercular scalaranes, both from natural products and from chemical derivatization, were subjected to structure-activity investigations. Based on the activity profile, three main regions; i.e., the substituted groups hovering over C-19/C-18 and furan moiety, the functionalities in the vicinity of C-16 and the right-hand side of ring D, and the substituted groups on C-12, were speculated as the areas influencing the antitubercular activity of the scalaranes. The results suggested the promising possibility for the further investigation toward the modes of actions and/or target sites of the compounds.

show abstract

“…Certain derivatives were also found in a nudibranch species, presumably via dietary accumulation [6]. Of particular interest among the scalaranes in this report is heteronemin (1).…”

Section: Introductionmentioning

confidence: 74%

Section: A Minor Scalarane Derivativementioning

confidence: 99%

Structure-activity relationships of antitubercular scalaranes: Heteronemin revisited

Jaisamut

Thengyai

Yuenyongsawad

et al. 2009

Pure and Applied Chemistry

View full text Add to dashboard Cite

show abstract

“…Philinopsis gardineri (Eliot, 1903 (Eliot 1906;Fontana et al 1999; 23. Glossodoris pallida (Rűppell & Leuckart, 1830 (Eliot, 1904).…”

Section: Resultsmentioning

confidence: 99%

An annotated checklist of opisthobranch fauna (Gastropoda: Opisthobranchia) of the Nicobar Islands, India

Sreeraj¹,

Sivaperuman²,

Raghunathan³

2012

J. Threat. Taxa

View full text Add to dashboard Cite

“…This structural feature is quite common in the homoscalarane series but unusual in the scalaranes, and in particular it has been encountered only in nudibranch metabolites. In fact, in addition to 12-deacetoxy-12-oxo-deoxoscalarin (80), previously isolated from Indian Glossodoris atromarginata [44] , only one 12-keto-scalarane, 12-deacetoxy-12-oxo-18-epi-scalaradial, from Pacific nudibranch Chromodoris youngbleuthi [45] , has been previously reported.…”

Section: Mollusksmentioning

confidence: 99%

Bioactive natural products from Chinese marine flora and fauna

Zhou

Guo

2012

Acta Pharmacol Sin

View full text Add to dashboard Cite

In recent decades, the pharmaceutical application potential of marine natural products has attracted much interest from both natural product chemists and pharmacologists. Our group has long been engaged in the search for bioactive natural products from Chinese marine flora (such as mangroves and algae) and fauna (including sponges, soft corals, and mollusks), resulting in the isolation and characterization of numerous novel secondary metabolites spanning a wide range of structural classes and various biosynthetic origins. Of particular interest is the fact that many of these compounds show promising biological activities, including cytotoxic, antibacterial, and enzyme inhibitory effects. By describing representative studies, this review presents a comprehensive summary regarding the achievements and progress made by our group in the past decade. Several interesting examples are discussed in detail.

show abstract

New Scalaranes from the Nudibranch Glossodoris atromarginata and Its Sponge Prey

Abstract: Two new scalaranes (1 and 2) have been isolated from the dorid nudibranch Glossodoris atromarginataand its prey. The structures were deteremined by spectral techniques and confirmed by chemical methods. Compounds 1 and 3 showed selective cytotoxic activity against human thyroid carcinoma.

Cited by 47 publications

References 16 publications

Structure-activity relationships of antitubercular scalaranes: Heteronemin revisited

Structure-activity relationships of antitubercular scalaranes: Heteronemin revisited

An annotated checklist of opisthobranch fauna (Gastropoda: Opisthobranchia) of the Nicobar Islands, India

Bioactive natural products from Chinese marine flora and fauna

Contact Info

Product

Resources

About