New seco-anthraquinone glucoside from the roots of Rumex crispus

Abstract

A new seco-anthraquinone, crispuside A (1), and three new 3,4-dihydronaphthalen-1(2H)-ones, napthalenones A-C (2–4), were isolated from the roots of Rumex crispus L., along with 10 known anthraquinones (6–14) and naphthalenone (5). Their structures were fully determined by extensive spectroscopic analyses, including ECD, and X-ray crystallography in case of compound 5, whose absolute configuration was determined for the first time. The isolates 1, 6–14 were evaluated for their anti-inflammatory and anti-fungal activity against three skin fungi, e.g., Epidermophyton floccosum, Trichophyton rubrum, and Microsporum gypseum. Most of the isolates showed weak anti-fungal and anti-inflammatory activity. Only compound 9 exhibited obvious anti-fungal activity against E. floccosum (MIC50 = 2.467 ± 0.03 μM) and M. gypseum (MIC50 = 4.673 ± 0.077 μM), while the MIC50 values of the positive control terbinafine were 1.287 ± 0.012 and 0.077 ± 0.00258 μM, respectively. The results indicated that simple emodin type anthraquinone is more potential against skin fungi than its oxyglucosyl, C-glucosyl and glycosylated seco analogues. Graphical Abstract

Monocyte (THP-1) Response to Silver Nanoparticles Synthesized with Rumex hymenosepalus Root Extract

“…Flavonoids (flavonols, flavones, isoflavone, chalcones, and anthocyanidin) are the most abundant polyphenols identified in the extract, and several of these compounds are present as Flavonoid Glycosides [ 30 ]. Unlike other reports for the genus Rumex, where the presence of anthranoids is abundant [ 27 , 31 ], in our study, only the compound 3,8-Dihydroxy-1-methylanthraquinone-2-carboxylic acid is identified. Table 1 shows the 25 compounds with the highest relative abundance in the extract.…”