New sesquiterpene coumarins from the roots ofFerula flabelliloba

Chemical composition and antibacterial activity of the essential oils from flower, leaf and stem ofFerula cupularisgrowing wild in Iran

“…Phytochemical analysis of Ferula species has confirmed the occurrence of biologically active compounds such as daucane sesquiterpenes, sulfur containing molecules, and coumarins (Dastan et al, 2012;Iranshahi et al, 2009Iranshahi et al, , 2010Sahebkar et al, 2010;Zedan et al, 2012). Some Ferula species are used in folk medicine as anticonvulsant, carminative, antispasmodic, diuretic, antihelmintic, tonic, laxative, anti-hysteric, decongestant, aphrodisiac, and some are applied for the treatment of neurological disorders, diabetes, rheumatism, and backache (Afifi & Abu-Irmaileh, 2000;Bagheri et al, 2010;Iranshahy & Iranshahi, 2011;Mahendra & Bisht, 2012;Zargari, 1996).…”

Modulation of Multidrug Resistance Protein 2 Efflux in the Cisplatin Resistance Human Ovarian Carcinoma Cells A2780/RCIS by Sesquiterpene Coumarins

“…Fourteen SCs (HPLC, purity >95%) were isolated from the roots of different Ferula species according to previous methods. Mogoltacin and mogoltadone were isolated from F. flabelliloba (Iranshahi et al, 2010a); galbanic acid, umbelliprenin, farnesiferol B, farnesiferol C, lehmferin, and microlobin were isolated from F. szowitsiana (Iranshahi, 2012); farnesiferol A had been isolated from Ferula persica previously (Iranshahi et al, 2004); conferone, conferdione, and gumoside B were isolated from F. gummosa (Iranshahi et al, 2010b); samarcandin and mogoltavidin were isolated from F. galbaniflua (Kasaian et al, 2014a). The chemical structures of SCs isolated from Ferula species are shown in Fig.…”

“…Ferula species from the family Apiaceae are rich sources of biologically active natural products including sulphur-containing compounds (Mozaffarian, 1996;Iranshahi et al, 2003a;Iranshahi et al, 2006;Iranshahi, 2012), sesquiterpene coumarins (SCs) (Iranshahi et al, 2004;Iranshahi et al, 2010a;Iranshahi et al, 2010b;Esmail Nazari and Iranshahi, 2011;Kasaian et al, 2014a), and sesquiterpenes (Iranshahi et al, 2003b;Iranshahi et al, 2008;Kasaian et al, 2014b). Some studies showed that SCs were able to enhance the cytotoxicity of * anticancer compounds (Behnam Rassouli et al, 2009;Neshati et al, 2009;Rassouli et al, 2011).…”

Recent Advances in the Synthesis of Coumarin Derivatives from Different Starting Materials

“…Seo et al and Bai et al isolated more than 20 coumarins from the roots of Angelica dahurica, which has healing properties [8,9]. Iranshahi et al reported isolation of three coumarins from roots Ferula flabelliloba, while Peng et al isolated two new coumarins from the roots of Clausena excavata [10,11]. Six coumarins were extracted from Ferulago suvelutina and showed moderate antioxidant activity.…”