New sesquiterpene dilactone and β-carboline alkaloid and the α-glucosidase inhibitory activity of selected phytochemicals from Neolitsea cassia (L.) Kosterm

Jani, Nor Akmalazura; Sirat, Hasnah Mohd; Ahmad, Farediah; Aminudin, Nurul Iman

doi:10.1080/14786419.2021.1961134

Cited by 11 publications

(4 citation statements)

References 25 publications

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“…Comparison among (+)-catechin ( 16 ), quercetin ( 21 ) and luteolin ( 28 ) suggested the saturation of the 2,3-double bond in the C ring seemed to decrease the inhibitory activity [ 48 ]. In addition, among the taxifolin ( 13 ) and derivatives ( 14, 15 ), taxifolin showed the strongest inhibitory effect, indicating that the presence of a sugar moiety at C-3 may be responsible for the lowered activity [ 49 ]. In addition, galloyl moieties strengthen the inhibitory effects of flavonoids against the α-glucosidase (such as compound 26 ) [ 50 ].…”

Section: Resultsmentioning

confidence: 99%

The Chemical Constituents of Diaphragma Juglandis Fructus and Their Inhibitory Effect on α-Glucosidase Activity

et al. 2022

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In our current investigation, 37 constituents (1–37), including 11 megastigmanes (1–11), 17 flavonoids (12–28) and 9 phenylpropanoids (29–37), were isolated from a 70%-EtOH extract of Diaphragma juglandis Fructus. Among them, compounds 1–3, 12 and 29 were new compounds and their structures were elucidated on the basis of physicochemical evidence and meticulous spectroscopic analysis (NMR, HRESIMS and CD). Compounds 13, 16, 21 and 28 showed moderate inhibitory effect on α-glycosidase inhibitory activities, with IC50 values being in the range of 29.47–54.82 µM and stronger than the positive control (acarbose, 60.01 ± 4.82 µM).

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Section: Resultsmentioning

confidence: 99%

The Chemical Constituents of Diaphragma Juglandis Fructus and Their Inhibitory Effect on α-Glucosidase Activity

et al. 2022

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“…Further investigation of compounds 1 to 37 in terms of α-glucosidase inhibitory activity revealed taxifolin, (+)-catechin, quercetin, and luteolin (IC50 values of 40.39, 54.82, 29.47, and 35.41 μM, respectively) exhibited stronger activity than the positive control acarbose (IC50 value of 60.01 μM). From the structural analysis of the compounds, it was found that the structures of the A, B, and C rings in flavonoids were closely related to the inhibitory activity; hydroxylation at the 3-position of flavonoids could enhance the inhibitory effect, saturation of the 2,3-double bond on the C ring could reduce the inhibitory activity [ 66 ], the presence of the glycosyl portion on C-3 could reduce the activity [ 67 ], and the gallic alcohol portion could enhance the inhibitory activity of flavonoids [ 68 ].…”

Section: Extractsmentioning

confidence: 99%

A Review on Extracts, Chemical Composition and Product Development of Walnut Diaphragma Juglandis Fructus

Zhan,

Ma,

Chen

et al. 2023

Foods

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Walnuts are one of the world’s most important nut species and are popular for their high nutritional value, but the processing of walnuts produces numerous by-products. Among them, Diaphragma Juglandis Fructus has attracted the attention of researchers due to its complex chemical composition and diverse bioactivities. However, comprehensive reviews of extract activity and mechanistic studies, chemical composition functionality, and product types are scarce. Therefore, the aim of this review is to analyze the extracts, chemical composition, and product development of Diaphragma Juglandis Fructus. Conclusions: For extracts, the biological activities of aqueous and ethanol extracts have been studied more extensively than those of methanol extracts, but almost all of the studies have been based on crude extracts, with fewer explorations of their mechanisms. For chemical composition, the bioactivities of polyphenols and polysaccharides were more intensively studied, while other chemical constituents were at the stage of content determination. For product development, walnuts are mainly used in food and medicine, but the product range is limited. In the future, research on the bioactivity and related mechanisms of Diaphragma Juglandis Fructus can be further expanded to improve its value as a potential natural plant resource applied in multiple industries.

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“…Sesquiterpene lactones, linderalactone, pseudoneolinderane, and linderanlide C (Figure 2), demonstrated strong AG inhibition with IC 50 values of 12.72, 47.07, and 12.10 μM, respectively. As a result of the study, it was stated that the presence of an α,β‐unsaturated γ‐lactone ring fragment in the C‐ring of sesquiterpene lactones was necessary to inhibit AG activity (Jani et al, 2021).…”

Section: Promising Candidates For Ag Inhibitory Activitymentioning

confidence: 99%

“…Compounds linderalactone, pseudoneolinderane, linderanlide C, linderanine A, epicatechin, and astilbin inhibited AG with IC 50 values ranging from 12.10 to 96.77 µM (Jani et al, 2021).…”

Section: Alkaloidsmentioning

confidence: 99%

Advances in the natural α‐glucosidase inhibitors

Şöhretoğlu,

Renda,

Arroo

et al. 2023

eFood

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Abstractα‐Glucosidase (AG) inhibitors, one of the classes of oral antidiabetics used to treat type 2 diabetes mellitus, delay digestion and absorption of glucose, which in turn, has a lowering effect on postprandial blood glucose and insulin levels. Natural products are a great source for the development of new AG inhibitory drug candidates. We aim to summarize advances in natural AG inhibitors according to their secondary metabolite groups in the last decade. Their mechanisms of action and structure–activity relationships will especially be discussed.

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New sesquiterpene dilactone and β-carboline alkaloid and the α-glucosidase inhibitory activity of selected phytochemicals from Neolitsea cassia (L.) Kosterm

Cited by 11 publications

References 25 publications

The Chemical Constituents of Diaphragma Juglandis Fructus and Their Inhibitory Effect on α-Glucosidase Activity

The Chemical Constituents of Diaphragma Juglandis Fructus and Their Inhibitory Effect on α-Glucosidase Activity

A Review on Extracts, Chemical Composition and Product Development of Walnut Diaphragma Juglandis Fructus

Advances in the natural α‐glucosidase inhibitors

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