New sesquiterpene from Vietnamese agarwood and its induction effect on brain-derived neurotrophic factor mRNA expression in vitro

Transcriptional Activation of Putative Calmodulin Genes Am-cam-1 and Am-cam-2 from Aquilaria microcarpa, in Response to External Stimuli

“…9) Two cDNA clones presumably encoding calmodulin (CAM), a key mediator protein of the Ca 2ϩ -cascade in eukaryotic cells, 10,11) were isolated from the culture to investigate the biochemical and molecular biological processes of MJ-induced activation of the sesquiterpene biosynthesis in A. microcarpa. A possible change in the transcriptional activities of these genes in A. microcarpa cells in response to various external stimuli was also examined.…”

Investigation of Agarwood Compounds in Aquilaria malaccensis & Aquilaria Rostrata Chipwood by Using Solid Phase Microextraction

“…HQ Wei proved chromone existence in agarwood known as 2-(2-phyenylethyl) and support that both sesquiterpene and chromone are the main active compound contribute to the fragrance [11]. The findings is strengthen by the earlier study by Ishihara and Uneyama who declared agarwood compounds consists of series of sesquiterpenes named as nor-ketoagarofuran, agarospirol, jinkoh-eremol and selina-3,11-dien-9-one [23], selina-3,11-dien-14-al , methyl selina-3,11-dien-14-oate,methyl 9-hydroxyselina-4,11-dien-14-oate, and a nor-sesquiterpens, 1,5-epoxy-nor-ketoguaiene [7,12,13]. Benzaldehyde, α-guaiene, β-dihydroagarofuran, α-bulnesene, epoxy bulnesene among other compound also reported by Tajuddin [14] A few years ago, De-Lan (2011) stated four fragrant sesquiterpenes, including agarofuran, 4-hydroxylbaimuxinol and three eremophilanes namely; 7b-H-9(10)-ene-11, 12-epoxy-8 oxoeremophilane,7a-H-9(10)-ene-11,12-epoxy-8-oxoeremophilane and neopetasane [6].…”

Bioactive Chromone Derivatives – Structural Diversity

“…(11)) [75] showed to be a promising candidate for the treatment of psychosis. Studies carried out on 2-(2-phenylethyl)chromones [74,81,82] allowed to conclude that those derivatives comprising a 5-OH substituent and a phenylethyl moiety at position 2 (Fig. (12)) display a significant protective effect against glutamate-induced neurotoxicity, already for a 10 μM concentration.…”

“…(3)) were reported to inhibit nitric oxide radical production [57,81]. In fact, NO is known to play a central role in inflammatory and immune reactions, excessive production leading to tissue damage (e.g.…”

“…rheumatoid arthritis). Phenylethylchromones (with different hydroxyl and methoxyl substitutions [82]), in turn, have shown remarkable effects, namely at the central nervous system -5-hydroxy-2-(2-phenylethyl)chromone, for instance, acts as a neuroprotector against glutamate-induced neurotoxicity [74,81]. Eugenitol (2,8-dimethyl-5,7-dihydroxy-chromone) and eugenitine (2,6-dimethyl-5-hydroxy-7-methoxy-chromone), which are important constituents of clove oil, were reported to behave as carcinogenesis inhibitors thanks to their remarkable antioxidant capacity.…”