New, simple, sensitive and validated spectrophotometric method for the determination of salicylhydroxamic acid in capsules and raw material according to the ICH guidelines

Azzam, Khaldun M. Al; Kassed, Wafaa El

doi:10.1016/j.ejbas.2017.07.001

Cited by 5 publications

(5 citation statements)

References 12 publications

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“…The p K a values for silica vary from 4.5 to 8.5 depending on the surface’s arrangement of the −SiOH groups. , Here, a p K a value of 7.5 was utilized, which was the mid value of 4.5 and 8.5 estimated by the surface complexation model . The p K a values of SHAM were 7.4 and 9.7 for the hydroxamic acid and phenol, resepectively . The p K a value of 9.5 was used for catechol .…”

Section: Methodsmentioning

confidence: 99%

“…45 The pK a values of SHAM were 7.4 and 9.7 for the hydroxamic acid and phenol, resepectively. 28 The pK a value of 9.5 was used for catechol. 46 The second pKa value (11.5) for catechol was not utilized in our calculations is higher than the pH range that we are considering.…”

Section: Jkr Contact Mechanicsmentioning

confidence: 99%

“…SHAM is also a known chelator of metal ions, which can potentially facilitate its binding to a metal surface. Additionally, SHAM deprotonates and protonates in response to pH without oxidation (p K a1 = 7.4 and p K a2 = 9.7). , Deprotonation of SHAM can potentially reduce its interfacial bonding capabilities (Figure b), making it suitable to function as a reversible, pH-responsive adhesive molecule.…”

Section: Introductionmentioning

confidence: 99%

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Salicylhydroxamic Acid as a Novel Switchable Adhesive Molecule

et al. 2023

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The feasibility of salicylhydroxamic acid (SHAM) to function as a pH-responsive, switchable adhesive molecule is explored here. Using a custom-built Johnson−Kendall−Roberts contact mechanics test setup, SHAM-containing adhesive demonstrated strong, wet adhesion to various surfaces (glass, titanium, polystyrene and amine-functionalized glass) at pH 5 with adhesive properties that were comparable to those of catechol. The work of adhesion of SHAM decreased by nearly 98% with increasing pH and fully recovered when treated with pH 5. Most impressively, SHAM recovered its adhesive property even after its exposure to pH as high as 11, indicating superior stability toward base treatment. This result contrasts the case of catechol, which did not recover its initial adhesive property due to irreversible oxidation. Finally, density functional theory calculations were used to confirm that the observed tunable adhesion property was due to the deprotonation of SHAM.

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Section: Methodsmentioning

confidence: 99%

Section: Jkr Contact Mechanicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Salicylhydroxamic Acid as a Novel Switchable Adhesive Molecule

et al. 2023

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“…Different analytical methods have been reported in the literature for SHAM determination, two among which are spectrophotometry ,− and liquid chromatography. − The reported spectrophotometric methods have low sensitivity, involve reactions with metal ions under strictly controlled conditions, and have poor selectivity because of the interference arising from the major drug degradation and metabolite products. Chromatographic methods suffer from different drawbacks such as time consumption because they require several manipulation steps, require expensive equipment, and require highly skilled analysts.…”

Section: Introductionmentioning

confidence: 99%

Paper-Based Potentiometric Device for Rapid and Selective Determination of Salicylhydroxamate as a Urinary Struvite Stone Inhibitor

et al. 2021

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Novel paper-based potentiometric platforms for rapid, costeffective, and simple determination of the salicylhydroxamic acid (SHAM) drug are presented. Both the SHAM sensor and the reference Ag/AgCl electrode were integrated together on the miniaturized paper platforms. The ion-sensing membrane for the presented sensor is based on the use of Sn IV -tetraphenylporphyrin (Sn IV TPP) as a charged carrier within a plasticized poly(vinyl chloride) (PVC) matrix. Multiwalled carbon nanotubes (MWCNTs) were used as an ion-to-electron transducer. The resulting sensor revealed a rapid and stable response with a Nernstian slope of −59.3 ± 0.7 mV/decade over the linear range of 1.0 × 10 −6 to 1.0 × 10 −3 M and a detection limit of 0.7 μM. All measurements were carried out in 30 mM phosphate-buffered solution (PBS) at pH 7.2. Intra-and interday precision were measured and found to be 1.7%. The relative standard deviation (RSD%) ( = 5) was calculated as 2.43% after utilizing five different electrodes (n = 5). The selectivity behavior of the prepared electrodes in the absence and presence of ionic additives was evaluated. The selectivity pattern showed a non-Hofmeister selectivity pattern in the existence of anionic additives with enhanced potentiometric selectivity for SHAM over different lipophilic anions (e.g., ClO 4 − , SCN − , and I − ). The presented device was successfully applied for SHAM determination in pharmaceutical preparations. This paper-based analytical device can be potentially manufactured at large scales and provides a portable, rapid, disposable, and cost-effective analytical tool for measuring the SHAM drug.

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“…Efficient and selective analytical methods for HA determination in plasma and urine samples are required for both dose regulation and clinical studies (pharmacokinetic–pharmacodynamic parameters, efficiency of the drugs) [ 6 , 7 ]. Up to date, several analytical methods have been used for HA determination: chromatographic [ 5 , 6 , 7 , 8 , 9 ], electrochemical [ 10 , 11 ], and spectrophotometric [ 12 , 13 ]. Some of the procedures are based on complexes formation between HA and metals [ 9 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Silica Xerogel Doped with Iron(III) as Sensor Material for Salicylhydroxamic Acid Determination in Urine

Morosanova

Kovalev

Моросанова

2021

Gels

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Salicylhydroxamic acid (SHA) is used as antimicrobic medicine and its concentration has to be monitored in urine. For the first time, silica xerogels doped with iron(III) have been proposed as sensor materials for SHA determination in biological samples. Three xerogels with iron(III) content in the range of 0.04–1.74% wt have been synthesized. BET surface area of these xerogels has varied in the range of 696–529 m2/g and total pore volume has varied in the range of 0.92–0.23 cm3/g. Complex formation between immobilized iron(III) and salicylhydroxamic acid has been investigated with solid phase spectrophotometry and IR spectroscopy. Orange-brown iron(III)-SHA complex with 1:1 stoichiometry is formed at pH 1–4 with half-reaction time of 17 min. Silica xerogel doped with 0.33% wt iron(III)) has been used as sensor material for SHA solid phase spectrophotometric determination (LOD 1.4 mg/L (n = 3), analytical range 4–230 mg/L). Proposed sensor material has been applied for SHA determination in biological samples of synthetic and human urine. The proposed procedure is characterized by a good level of accuracy (recovery values 97–120%) and precision (RSD values 4–9%) and can be recommended for pharmacokinetic–pharmacodynamic studies of hydroxamic acid-based medications.

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New, simple, sensitive and validated spectrophotometric method for the determination of salicylhydroxamic acid in capsules and raw material according to the ICH guidelines

Cited by 5 publications

References 12 publications

Salicylhydroxamic Acid as a Novel Switchable Adhesive Molecule

Salicylhydroxamic Acid as a Novel Switchable Adhesive Molecule

Paper-Based Potentiometric Device for Rapid and Selective Determination of Salicylhydroxamate as a Urinary Struvite Stone Inhibitor

Silica Xerogel Doped with Iron(III) as Sensor Material for Salicylhydroxamic Acid Determination in Urine

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