New simple synthesis of ring-fused 4-alkyl-4H-3,1-benzothiazine-2-thiones: Direct formation from carbon disulfide and (E)-3-(2-aminoaryl)acrylates or (E)-3-(2-aminoaryl)acrylonitriles

Abstract

SummaryA new simple and efficient method to construct ring-fused 4-alkyl-4H-3,1-benzothiazine-2-thione derivatives has been developed from carbon disulfide and (E)-3-(2-aminoaryl)acrylates or (E)-3-(2-aminoaryl)acrylonitriles under mild conditions, without the need for a metal catalyst. The newly developed method tolerates a wide range of substrates in moderate to excellent yields. Moreover, this method is advantageous over previous ones for the easy synthesis of reactants.

A magnetically recyclable iron oxide-supported copper oxide nanocatalyst (Fe3O4–CuO) for one-pot synthesis of S-aryl dithiocarbamates under solvent-free conditions

“…They have many potential applications as versatile synthetic intermediates, [46][47][48][49][50][51][52] linkers in solid phase organic synthesis, 53,54 protecting groups in peptide synthesis, 55,56 agrochemicals, [57][58][59] and biologically active compounds. 60,61 They are used in the rubber industry as vulcanization accelerators, 62,63 in medicinal chemistry [64][65][66][67] and recently as single precursor sources for the preparation of nanoparticles. [68][69][70][71] Conventional methods for their synthesis involve reactions of amines with toxic and expensive reagents, such as thiophosgene or an isothiocyanate, which are not environmentally acceptable.…”