New skin tissue engineering scaffold with sulfated silk fibroin/chitosan/hydroxyapatite and its application

Ma, P.; Li, Mengyun; Jinglong, Hu; Danqian, Li; Yan, Tao; Xu, Lei; Han, Zheng‐Fu; Jianlong, Da; Li, Lingyan; Zhao, Guizhe; Wang, Zhiping

doi:10.1016/j.bbrc.2022.11.086

Cited by 14 publications

(7 citation statements)

References 18 publications

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“…As one of the three primary elements of tissue engineering, scaffolds serve as pivotal frame materials to support tissue formation. In recent years, scaffolds have been widely used in bone [11][12][13], vessels [14][15][16][17], skin [18,19], nerve [20][21][22], cornea [23,24], tendon [25], and periodontal tissue engineering [26][27][28].…”

Section: Tissue Engineering Scaffolds For Vascular Regenerationmentioning

confidence: 99%

Chitosan Hydrogel as Tissue Engineering Scaffolds for Vascular Regeneration Applications

Wang

Feng

2023

Gels

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Chitosan hydrogels have a wide range of applications in tissue engineering scaffolds, mainly due to the advantages of their chemical and physical properties. This review focuses on the application of chitosan hydrogels in tissue engineering scaffolds for vascular regeneration. We have mainly introduced these following aspects: advantages and progress of chitosan hydrogels in vascular regeneration hydrogels and the modification of chitosan hydrogels to improve the application in vascular regeneration. Finally, this paper discusses the prospects of chitosan hydrogels for vascular regeneration.

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Section: Tissue Engineering Scaffolds For Vascular Regenerationmentioning

confidence: 99%

Chitosan Hydrogel as Tissue Engineering Scaffolds for Vascular Regeneration Applications

Wang

Feng

2023

Gels

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“…Upon comparing the results, it was found that the SSF/CS/HA and SF/CS/HA groups displayed favorable cytotoxicity conditions, whereas the SSF/CS/HA scaffold group showed a higher statistical outcome on the 7th day of animal experimental application. Consequently, it was concluded that the designed scaffold is biocompatible and biodegradable; it promotes cell viability and proliferation, suggesting its potential for use in wound healing [82].…”

Section: Silk Fibroin In Skin and Wound Tissue Engineeringmentioning

confidence: 99%

Advanced Applications of Silk-Based Hydrogels for Tissue Engineering: A Short Review

Akdag,

Ulag,

Kalaskar

et al. 2023

Biomimetics

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Silk has been consistently popular throughout human history due to its enigmatic properties. Today, it continues to be widely utilized as a polymer, having first been introduced to the textile industry. Furthermore, the health sector has also integrated silk. The Bombyx mori silk fibroin (SF) holds the record for being the most sustainable, functional, biocompatible, and easily produced type among all available SF sources. SF is a biopolymer approved by the FDA due to its high biocompatibility. It is versatile and can be used in various fields, as it is non-toxic and has no allergenic effects. Additionally, it enhances cell adhesion, adaptation, and proliferation. The use of SF has increased due to the rapid advancement in tissue engineering. This review comprises an introduction to SF and an assessment of the relevant literature using various methods and techniques to enhance the tissue engineering of SF-based hydrogels. Consequently, the function of SF in skin tissue engineering, wound repair, bone tissue engineering, cartilage tissue engineering, and drug delivery systems is therefore analysed. The potential future applications of this functional biopolymer for biomedical engineering are also explored.

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“…Silk fibroin (SF) has garnered considerable attention in the field of material science due to its biocompatibility, biodegradability, and exceptional mechanical qualities, as well as its simplicity of modification [28]. For example, Eivazzadeh-Keihan et al fabricated a nanobiocomposite scaffold with antimicrobial activity and improved mechanical properties by cross-linking a chitosan-based hydrogel with SF [29].…”

Section: Introductionmentioning

confidence: 99%

Functionalized Bacteriophages Silk Fibroin-Based Films with Antimicrobial Potential

Osire,

Wang,

et al. 2023

Preprint

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Scaffolds used for tissue/ bone defect repair must possess versatile properties suitable for each specific application. The issue of antibiotic resistance poses a significant challenge in bone tissue engineering especially when dealing with microbial infections. The most effective approach to address this challenge is to promote the integration of tissue before bacteria can adhere to it, hence preventing the proliferation of certain bacterial strains on the implant. The utilization of 3D printing and or the use of various composite polymers in scaffolds to create antibacterial scaffolds that possess both adequate mechanical strength and exceptional biocompatibility is an attractive approach for addressing the challenges associated with microbial infections in tissue. Herein, a new phage functionalized scaffold was created through surface charge modification of the composite scaffold with polyethyleimine (PEI). Afterwards, the PEI polymerized Scaffolds were incubated with phage lysate for approximately 2h prior to rinsing with ethanol. The morphological and physiochemical properties of formed scaffold were assessed through Raman spectrophotometry while the antibacterial assays were done through growth inhibition zones/ cell viability assays. The polymerized phage composite SF20_PEI.AR9 possessed the highest antimicrobial effect with clear inhibition zones of about 78.30 mm. This could be attributed to the lytic effect of phages on the bacterial cells. Moreover, the enhanced phage effect on the scaffolds was also associated to the improved surface charge on the scaffold, 78,3±7,6 mm which ultimately promoted phage scaffold interface integration hence the high antibacterial activity. The PEI polymerization approach could serve as a model for future development of phage scaffolds.

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New skin tissue engineering scaffold with sulfated silk fibroin/chitosan/hydroxyapatite and its application

Cited by 14 publications

References 18 publications

Chitosan Hydrogel as Tissue Engineering Scaffolds for Vascular Regeneration Applications

Chitosan Hydrogel as Tissue Engineering Scaffolds for Vascular Regeneration Applications

Advanced Applications of Silk-Based Hydrogels for Tissue Engineering: A Short Review

Functionalized Bacteriophages Silk Fibroin-Based Films with Antimicrobial Potential

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