New Solasodine‐Type Glycoalkaloids Isolated from Solanum nigrum and Their Cytotoxic Activity

Abstract

Three undescribed solalodine‐type glycoalkaloids, named solanigrinoside A–C (1–3), and six known compounds (4–9) were isolated from the whole plants of Solanum nigrum. Their structures were elucidated based on analysis of HR‐ESI‐MS, 1D‐ and 2D‐NMR spectral data, and comparison with those reported in literatures. The solanigrinoside A–C (1–3), solasodine (4), and 3‐acetoxysolasodine (5) exhibited cytotoxic effects against LU‐1, Hep‐G2, and MCF‐7 cells with IC50 values in range from 4.6 µM to 56.2 µM. Compound 2 showed the significant cytotoxic activity with corresponding IC50 values of 5.7 µM, 7.9 µM, and 4.6 µM, respectively.