The motion of water conveying copper and aluminum nanoparticles on a heated moving sheet when thermal radiation and stretching/shrinking surface is significant and is investigated in this study to announce the increasing effects of volume fractions, thermal radiation, and moving parameters on this transport phenomenon. Furthermore, the flow of a
Cu
−
Al
2
O
3
/water hybrid nanofluid across a heated moving sheet has been studied in both cross and streamwise directions. Thermal radiation effect is also considered, as this effect along with cross flow has not yet been investigated for the hybrid nanofluid in the published literature. Two distinct types of nanoparticles, namely,
Al
2
O
3
(alumina) and
Cu
(copper), have been used to prepare hybrid nanofluid where water is considered as a base fluid. The system of nonlinear partial differential equations (PDEs) has been transferred to ordinary differential equations (ODEs) by compatible transformations before solving them by employing the III-stage Lobatto-IIIa method in bvp4c solver in MATLAB 2017 software. Temporal stability analysis has been carried out in order to verify stable branch between two branches by obtaining the smallest eigenvalue values. The branches obtained are addressed in depth against every applied parameter using figures and tables. The results show that there are three ranges of branches, no solution exists when
λ
>
λ
c
, dual branches exist when
0.23
≤
λ
≤
λ
c
, and a single solution exists when
λ
>
0.23
. Moreover, thermal layer thickness declines initially and then enhances in the upper and lower solutions for the higher values of the thermal radiation parameter.