New Sonographic Criteria for Recommending Fine-Needle Aspiration Biopsy  of Nonpalpable Solid Nodules of the Thyroid

Kim, Min Jung; Park, Cheong Soo; Chung, Woung Youn; Oh, Ki Keun; Kim, Dong Ik; Lee, Jong Tae; Yoo, Hyung Sik

doi:10.2214/ajr.178.3.1780687

Cited by 942 publications

(923 citation statements)

References 17 publications

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“…An ill-defined margin may be associated with minimal marginal tumor infiltration of malignancy. Both characteristics suggest malignant infiltration of adjacent thyroid parenchyma with (Kim et al, 2002;Reading et al, 2005;Hoang et al, 2007). In our study, a poorly-circumscribed, ill-defined or irregular and microlobulated margin (Figs.…”

Section: Discussionsupporting

confidence: 59%

“…Ultrasound features predictive of malignant nodules include the presence of irregular margins, marked hypoechogenicity, microcalcifications, taller-than-wide shape, and intranodular vascularity (Kim et al, 2002;Hoang et al, 2007;Moon W.J. et al, 2008;Cooper et al, 2009;Ahn et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, nodules can be classified according to their contours as either smooth and rounded or irregular and microlobulated (Hoang et al, 2007). An ill-defined and irregular or microlobulated margin is suggestive of malignancy, but the sensitivity (48.3%-84.4%) and specificity (81%-97.6%) are variable (Kim et al, 2002;Papini et al, 2002;Cappelli et al, 2006;Hoang et al, 2007;Moon W.J. et al, 2008;Ahn et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…et al, 2008;Ahn et al, 2010). Some investigators have suggested an ill-defined margin as the criterion for the discrimination of malignant from benign nodules (Cappelli et al, 2006;Dighe et al, 2008), others have suggested an irregular or microlobulated margin as the criterion (Kim et al, 2002;Papini et al, 2002;Ahn et al, 2010). Poor interobserver agreement when assessing margins may account for these discordant findings.…”

Section: Discussionmentioning

confidence: 99%

“…et al, 2008). Although individual sonographic features may be of limited value, when multiple signs of thyroid malignancy appear in combination, it is possible to make accurate predictions (Kim et al, 2002;Ahn et al, 2010). However, whether the diagnostic accuracy of these features may be dependent on nodular size has not been fully investigated.…”

Section: Introductionmentioning

confidence: 99%

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Impact of nodular size on the predictive values of gray-scale, color-Doppler ultrasound, and sonoelastography for assessment of thyroid nodules

Hong

Luo

et al. 2012

J. Zhejiang Univ. Sci. B

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Abstract:Objective: To define the roles of gray-scale, color-Doppler ultrasound, and sonoelastography for the assessment of thyroid nodule to determine whether nodule size affects the differential diagnosis of benign and malignant. Methods: A total of 243 consecutive subjects (214 women, 29 men) with 329 thyroid nodules were examined by gray-scale, color-Doppler ultrasound, and sonoelastography in this prospective study. All patients underwent surgery and the final diagnosis was obtained from histopathological examination. Results: Three hundred and twenty-nine nodules (208 benign, 121 malignant) were divided into small (SNs, 5-10 mm, n=137) and large (LNs, >10 mm, n=192) nodules. Microcalcifications were more frequent in malignant LNs than in malignant SNs, but showed no significant difference between benign LNs and SNs. Poorly-circumscribed margins were not significantly different between malignant SNs and LNs, but were less frequent in benign LNs than in benign SNs. Among all nodules, marked intranodular vascularity was more frequent in LNs than in SNs. By comparison, shape ratio of anteroposterior to transverse dimensions (A/T) ≥1 was less frequent in LNs than in SNs. Otherwise, among all nodules, marked hypoechogenicity and elasticity score of 4-6 showed no significant difference between LNs and SNs. Conclusions:The predictive values of microcalcifications, nodular margins, A/T ratio, and marked intranodular vascularity depend on nodule size, but the predictive values of echogenicity and elastography do not.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of nodular size on the predictive values of gray-scale, color-Doppler ultrasound, and sonoelastography for assessment of thyroid nodules

Hong

Luo

et al. 2012

J. Zhejiang Univ. Sci. B

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Effect of Thyroid Gland Volume in Preoperative Detection of Suspected Malignant Thyroid Nodules in a Multinodular Goiter

Erbil

Barbaros²,

Salmaslıoğlu³

et al. 2008

Arch Surg

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The detection of suspected malignant thyroid nodules by ultrasonography is associated with thyroid gland volume and tumor size. Design: Prospective clinical trial. Setting: A tertiary referral center. Patients: Three hundred sixty-five patients with a multinodular goiter with coexistent dominant nodules. Main Outcome Measures: The correlation between thyroid gland volume and tumor size and the detection of suspected malignant thyroid nodules by ultrasonography. The incidence of thyroid carcinoma inside and outside the dominant nodules and thyroid gland volume and tumor size in suspected or unsuspected malignant thyroid nodules by ultrasonography were determined. Receiver operating characteristic analysis was used to identify the cutoffs of the tumor size and thyroid gland volume. Results: One hundred thyroid carcinomas were found in 69 (18.9%) patients. Forty-one of these carcinomas were inside the dominant nodule, whereas 59 were outside the dominant nodule. Only 9 of the 59 thyroid carcinomas outside the dominant nodules were suspected of being malignant by ultrasonography. Thyroid gland volume less than 38 mL and tumor size larger than 7 mm had 48-fold (odds ratio, 48; PϽ.001) and 21.5-fold (odds ratio, 21.5; PϽ.001) increased rates, respectively, of detecting suspected malignant thyroid nodules by ultrasonography. Conclusions: Thyroid gland volume and tumor size were significantly associated with detection of suspected malignant thyroid nodules by ultrasonography. Small thyroid gland volume was associated with detection of suspected malignant thyroid nodules in multinodular goiters.

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Risk of Thyroid Cancer Based on Thyroid Ultrasound Imaging Characteristics

et al. 2013

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New Sonographic Criteria for Recommending Fine-Needle Aspiration Biopsy of Nonpalpable Solid Nodules of the Thyroid

Abstract: Considering the high level of sensitivity of our proposed sonographic classification, fine-needle aspiration biopsy should be performed on thyroid nodules classified as positive, regardless of palpability.

Cited by 942 publications

References 17 publications

Impact of nodular size on the predictive values of gray-scale, color-Doppler ultrasound, and sonoelastography for assessment of thyroid nodules

Impact of nodular size on the predictive values of gray-scale, color-Doppler ultrasound, and sonoelastography for assessment of thyroid nodules

Effect of Thyroid Gland Volume in Preoperative Detection of Suspected Malignant Thyroid Nodules in a Multinodular Goiter

Risk of Thyroid Cancer Based on Thyroid Ultrasound Imaging Characteristics

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