New source identification of mercury contamination in the Great Lakes

Glass, Gary E.; Sorensen, John A.; Schmidt, Kent W.; Rapp, George

doi:10.1021/es00077a017

Cited by 66 publications

(33 citation statements)

References 17 publications

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“…Therefore, the observations of higher THg concentrations deeper within the core at the central locations, suggests that historical watershed loads were larger than contemporary inputs, which is a conclusion supported by dated sediment cores from the reservoir (Curtis et al, 2013). Overall, the sediment THg concentrations measured in our study were higher than concentrations typically observed in background sediments (mean range: 0.1-0.2 lg/g; Glass et al (1990), Krabbenhoft et al (1999)), and likely reflect the influence of historical mining activity in the watershed. At the three seasonally inundated sediment sample locations, the MeHg concentration were all clearly higher in the top 0-2 cm of the sediment compared to lower depths (Fig.…”

Section: Reservoir Sediment Thg and Mehgsupporting

confidence: 74%

Influence of reservoir water level fluctuations on sediment methylmercury concentrations downstream of the historical Black Butte mercury mine, OR

Eckley

Luxton

McKernan

et al. 2015

Applied Geochemistry

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Section: Reservoir Sediment Thg and Mehgsupporting

confidence: 74%

Influence of reservoir water level fluctuations on sediment methylmercury concentrations downstream of the historical Black Butte mercury mine, OR

Eckley

Luxton

McKernan

et al. 2015

Applied Geochemistry

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“…Background concentrations in Lake Geneva sediments are B0.2 mg kg À 1 . Although the chemistry and transport behavior of Hg is complex, particulate transport is dominant in most systems (Glass et al, 1990;Wang et al, 2004). Assuming that particleassociated bacteria or bacterial aggregates released from the WWTP are in turn primarily responsible for ARG deposition in the sediment, we expected a similar pollution pattern for THg and ARGs.…”

Section: Comparison Of Args and Hg Contaminationmentioning

confidence: 95%

Wastewater as a point source of antibiotic-resistance genes in the sediment of a freshwater lake

2014

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Antibiotic-resistance genes (ARGs) are currently discussed as emerging environmental contaminants. Hospital and municipal sewage are important sources of ARGs for the receiving freshwater bodies. We investigated the spatial distribution of different ARGs (sul1, sul2, tet(B), tet(M), tet(W) and qnrA) in freshwater lake sediments in the vicinity of a point source of treated wastewater. ARG contamination of Vidy Bay, Lake Geneva, Switzerland was quantified using real-time PCR and compared with total mercury (THg), a frequently particle-bound inorganic contaminant with known natural background levels. Two-dimensional mapping of the investigated contaminants in lake sediments with geostatistical tools revealed total and relative abundance of ARGs in close proximity of the sewage discharge point were up to 200-fold above levels measured at a remote reference site (center of the lake) and decreased exponentially with distance. Similar trends were observed in the spatial distribution of different ARGs, whereas distributions of ARGs and THg were only moderately correlated, indicating differences in the transport and fate of these pollutants or additional sources of ARG contamination. The spatial pattern of ARG contamination and supporting data suggest that deposition of particle-associated wastewater bacteria rather than co-selection by, for example, heavy metals was the main cause of sediment ARG contamination.

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“…Elemental mercury is eventually removed from the atmosphere by oxidation to a water-soluble species and by dry deposition. Although large-scale releases of mercury have been controlled in the United States, atmospheric transport implicates smaller sources (combustion of coal, municipal solid waste and sewage sludge) as the cause of widespread elevations of mercury concentrations in remote ecosystems [7].…”

Section: Introductionmentioning

confidence: 99%

Mercury Induces Cytotoxicity and Transcriptionally Activates Stress Genes in Human Liver Carcinoma (HepG2) Cells

Sutton

Tchounwou

Ninashvili

et al. 2002

IJMS

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Abstract:Mercury is a non-essential element that exhibits a high degree of toxicity to humans and animals. Exposure to mercury has been associated with a significant number of adverse health effects including: cardiovascular disease, anemia, developmental abnormalities, neurobehavioral disorders, kidney and liver damage, and cancer in some cases. In several studies, the toxicity of mercury has been attributed to its high affinity to protein-containing sulfhydryl groups. However, little is known regarding the molecular mechanisms by which mercury exerts its toxicity, mutagenesis, and carcinogenesis. This research was therefore designed to assess the cellular and molecular responses of human liver carcinoma cells following exposure to mercury. Cytotoxicity was evaluated using the MTT-assay for cell viability, while the gene profile assay was performed to measure the transcriptional activation of stress genes in thirteen different recombinant cell lines generated from HepG 2 cells. Cytotoxicity experiment yielded a LD 50 value of 3.5 ± 0.6 µg/mL upon 48 hours of exposure, indicating that mercury is highly toxic. A dose response relationship was recorded with respect to both cytotoxicity and gene induction. Overall, nine out of the thirteen recombinant cell lines tested showed inductions to statistically significant levels (p<0.05). At 2.5 µg/mL of mercury, the average fold inductions were 5.2 ± 0.9, 21.4 ± 3.9, 7.0 ± 6.2, 6.8 ± 1.1, 2.7 ± 1.0, 4.5 ± 2.0, 7.5 ± 6.0, 2.2 ± 0.7, and 2.5 ± 0.3, for GSTYa, HMTIIA, c-fos, HSP70, CRE, p53RE, GADD153, GADD45, and GRP78, respectively. These results indicate the potential of mercury to undergo Phase II biotransformation in the liver (GSTYa), and to cause protein damage (HMTIIA, HSP70, and GRP78), cell proliferation (c-fos), metabolic perturbation (CRE), growth arrest and DNA Int. J. Mol. Sci. 2002, 3 966 damage (GADD153, GADD45), and apoptosis (p53RE). No significant inductions (p> 0.05) were observed for CYP1A1, XRE, NFkBRE, and RARE.

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New source identification of mercury contamination in the Great Lakes

Cited by 66 publications

References 17 publications

Influence of reservoir water level fluctuations on sediment methylmercury concentrations downstream of the historical Black Butte mercury mine, OR

Influence of reservoir water level fluctuations on sediment methylmercury concentrations downstream of the historical Black Butte mercury mine, OR

Wastewater as a point source of antibiotic-resistance genes in the sediment of a freshwater lake

Mercury Induces Cytotoxicity and Transcriptionally Activates Stress Genes in Human Liver Carcinoma (HepG2) Cells

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