New SPECT and PET Radiopharmaceuticals for Imaging Inflammatory Diseases: A Narrative Review

Pacilio, Marta; Lauri, Chiara; Prosperi, Daniela; Petitti, Agnese

doi:10.1053/j.semnuclmed.2017.12.004

Cited by 25 publications

(13 citation statements)

References 84 publications

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“…The present findings regarding the relationship between GO clinical activity and 99mTc‐anti‐TNF‐α SCI results suggest that greater orbit inflammation may be associated with a better therapeutic response to corticosteroids. As seen previously (Wakelkamp et al ., ; Pacilio et al ., ), CorT was associated with decreases in Th1 cytokines (TNF‐α and gamma interferon) and increases in Th2 cytokines (IL‐4 and IL‐10).…”

Section: Discussionmentioning

confidence: 87%

Technetium‐99m‐anti‐tumour necrosis factor alpha scintigraphy as promising predictor of response to corticotherapy in chronic active Graves' ophthalmopathy

Lacerda

Souza

Gutfilen

et al. 2018

Clin Physio Funct Imaging

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Summary It has been suggested that technetium‐99m (99mTc)‐anti‐tumour necrosis factor alpha (TNF‐α) scintigraphy (SCI) may be a useful diagnostic tool in Graves' ophthalmopathy (GO). This study evaluated whether orbit total radioactivity uptake on SCI could be used to predict corticosteroid therapy (CorT) responses in active‐GO patients. A longitudinal study of patients with active GO defined by Clinical Active Score (CAS) >3/7 was done. Clinical, laboratory and SCI evaluations were performed at baseline and 3 months after concluding intravenous CorT. SCI (planar and tomographic) was assessed after intravenous injection of 10 mCi of 99mTc‐anti‐TNF‐α. Orbits and cerebral hemispheres were defined as regions of interest (ROIs) to enable orbit/hemisphere ROI‐ratios of total radioactive uptake. ROI‐ratios were considered positive at >2·5. Average total radiation uptake (TRU) was also determined for each orbit (AVGROI). Clinical, laboratory and SCI data were compared between responders (CAS became inactive) and non‐responders to CorT (18 patients). At baseline, AVGROI were higher in active OG orbits (67·3 cps) than in inactive ones (33·6 cps; P<0·05). AVGROI (absolute values) reduced (−29·9 cps) in CorT responders and tended (P = 0·067) to differ from variations occurred in non‐responders (+6·9 cps in patients with maintained CAS positivity post‐treatment). Higher baseline ROI‐ratios (4·9 versus 3·3; P = 0·056) and its pronounced reductions following CorT (−37% versus +56% in non‐responders; P = 0·036) tended to be associated with good CorT responses in the subgroup of GO history ≥1 year. SCI showed a good association with active eye disease and may be an additional tool to identify CorT responders.

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Section: Discussionmentioning

confidence: 87%

Technetium‐99m‐anti‐tumour necrosis factor alpha scintigraphy as promising predictor of response to corticotherapy in chronic active Graves' ophthalmopathy

Lacerda

Souza

Gutfilen

et al. 2018

Clin Physio Funct Imaging

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“…Furthermore, radiopharmaceuticals beyond 18 F-FDG have been developed for evaluating inflammatory diseases, in particular to define new strategies for imaging immune cells as well as tissue modifications induced by the inflammatory process [77].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Performance of ¹⁸F-FDG PET/CT in Infectious and Inflammatory Diseases according to Published Meta-Analyses

Treglia

2019

Contrast Media & Molecular Imaging

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Purpose. To date, several meta-analyses have reported data about the diagnostic performance of 18F-FDG PET/CT in infectious and inflammatory diseases. This article aims to summarize the published evidence-based data about the diagnostic performance of 18F-FDG PET/CT in this setting. Methods. A comprehensive computer literature search of meta-analyses published in PubMed/MEDLINE and Cochrane library database from January 2009 through December 2018 and regarding the diagnostic performance of 18F-FDG PET/CT in infectious and inflammatory diseases was carried out. This combination of key words was used: (i) “PET” OR “positron emission tomography” OR “FDG” OR “fluorodeoxyglucose” AND (ii) meta-analysis. Only records on inflammatory or infectious diseases were selected. Results. The diagnostic performance of 18F-FDG PET/CT in detecting inflammatory and infectious diseases has been summarized taking into account 36 meta-analyses published in the literature. Evidence-based data demonstrated good diagnostic performance of 18F-FDG PET/CT for several inflammatory and infectious diseases, in particular cardiovascular infectious and inflammatory diseases and some musculoskeletal infections. Conclusions. Evidence-based data about the diagnostic performance of 18F-FDG PET/CT in infectious and inflammatory diseases are increasing, with good diagnostic performance of this imaging method for some indications. More prospective multicenter studies and cost-effective analyses are warranted.

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“…In fact, 18 F‐FDG PET is also used for detecting tumors 49a,50b,51 . Hence, for more specific detection and assessment of inflammation, various imaging tracers that target diverse biomarkers have been developed 10b,49e,53 …”

Section: Strategies For Visualizing Inflammationsmentioning

confidence: 99%

Strategies for visualizing inflammation

Zhang

Liu

Guo

et al. 2020

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As a basic innate immune response to the disordered tissue homeostasis, inflammation is related to the pathogenesis of multiple diseases, including bacterial infections, atherosclerosis, neurodegenerative diseases, and cancers. It is also a pivotal feature of some metabolic disorders such as diabetes and obesity. The visualization of in vivo inflammations can help us to comprehend the pathogenesis of these diseases and develop new solutions to diagnose them. Over the past few decades, a variety of strategies (eg, computed tomography, magnetic resonance imaging [MRI], and ultrasound [US] imaging) have been utilized for visualizing inflammations by imaging the structural changes of inflammatory tissues. Moreover, many recent studies have focused on some probes that can target or localize the inflammatory sites by specific binding to inflammation‐related molecules, being internalized by inflammatory cells, or becoming detectable only under inflammatory conditions. These probes can also be applied to visualize inflammations by MRI, positron emission tomography, single‐photon emission computed tomography, photoacoustic imaging, optical imaging (eg, fluorescence imaging, bioluminescence imaging, and chemiluminescence imaging), contrast‐enhanced US imaging, and the combined use of the abovementioned methods. This review not only summarizes the existing strategies for visualizing inflammations, but also discusses the limitations of the present strategies and the future directions on the development of new strategies for realizing the in vivo inflammation visualization.

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New SPECT and PET Radiopharmaceuticals for Imaging Inflammatory Diseases: A Narrative Review

Cited by 25 publications

References 84 publications

Technetium‐99m‐anti‐tumour necrosis factor alpha scintigraphy as promising predictor of response to corticotherapy in chronic active Graves' ophthalmopathy

Technetium‐99m‐anti‐tumour necrosis factor alpha scintigraphy as promising predictor of response to corticotherapy in chronic active Graves' ophthalmopathy

Diagnostic Performance of ¹⁸F-FDG PET/CT in Infectious and Inflammatory Diseases according to Published Meta-Analyses

Strategies for visualizing inflammation

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New SPECT and PET Radiopharmaceuticals for Imaging Inflammatory Diseases: A Narrative Review

Cited by 25 publications

References 84 publications

Technetium‐99m‐anti‐tumour necrosis factor alpha scintigraphy as promising predictor of response to corticotherapy in chronic active Graves' ophthalmopathy

Technetium‐99m‐anti‐tumour necrosis factor alpha scintigraphy as promising predictor of response to corticotherapy in chronic active Graves' ophthalmopathy

Diagnostic Performance of 18F-FDG PET/CT in Infectious and Inflammatory Diseases according to Published Meta-Analyses

Strategies for visualizing inflammation

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Product

Resources

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Diagnostic Performance of ¹⁸F-FDG PET/CT in Infectious and Inflammatory Diseases according to Published Meta-Analyses