New Steroidal Glycosides from Balanites aegyptiaca

Balanites aegyptiaca (L.) Del. (Hingot): A review of its traditional uses, phytochemistry and pharmacological properties

“…[39] Antimicrobial Activity Different studies were carried out to determine the antibacterial and antifungal activities of whole plant, root bark, stem bark, fruit mesocarp and leaves of B. aegyptiaca. [40][41][42][43][44][45][46] Antibacterial activity The leaf extracts of B. aegyptiaca, prepared in aqueous and organic solvents (acetone and ethanol), were tested for their antibacterial activity against Salmonella typhi, by using the disc diffusion method. Ethanolic extracts demonstrated higher antibacterial activity (16 mm zone of inhibition) while the aqueous extracts showed the least activity (4 mm zone of inhibition) at 100 mg/ml.…”

Anti-inflammatory, anti-nociceptive and antioxidant activities of Balanites aegyptiaca (L.) Delile

“…The presence of fragment ion at m/z 749.4428 indicated the elimination of a OSO 3 Na group. On the basis of its spectral data and by comparison with published data on similar compounds (Farid et al, 2002), compound 1 was identified as (3␤,12␤,14␤,16␤) cholest-5-ene-3,16-diyl bis (␤-dglucopyranoside)-12-sulphate, called Balanin 1, a new sterol sulfonate.…”

“…The 1 H-NMR spectrum of 2 revealed the presence of a steroidal structure with glycoside moiety. The 13 C-NMR spectrum and the HMBC experiment revealed the presence of a quaternary carbon signal at δ 112.9 which suggested the presence of a furostane skeleton possessing an oxygen function at C-22 (Farid et al, 2002). In the 1 H-NMR spectrum were also present signals consistent with five methyl groups, two linked to quaternary carbons at δ 0.81 and 1.03, C-18 and C-19 respectively and three linked to secondary carbons at δ 0.89, 1.15 and 1.21 assigned to position C-21, C-25 and C-6 of Rha respectively.…”

“…More recently five new steroidal glycosides were isolated from the roots of the plant (Farid et al, 2002).…”

Unraveling the active hypoglycemic agent trigonelline in Balanites aegyptiaca date fruit using metabolite fingerprinting by NMR

“…The fruit is also edible, sweet as most real date fruits are, but with some bitterness which discourages its use as a food complement. In Egyptian folk medicine, B. aegyptiaca fruits are long recognized as an oral hypoglycemic and antidiabetic agent [8]: aqueous extracts of the fruit mesocarp are used by locals in Sudanese folk medicine for treatment of jaundice and as an anthelmintic [9,10]. The balanites fruit antidiabetic effect until now is thought to be mediated by steroidal saponins containing diosgenin as an aglycon (Balanitin A-F) [11,12].…”