New Strategies in the Treatment and Prophylaxis of Chemo- and Radiotherapy-Induced Oral Mucositis

Rosenthal, Christoph; Karthaus, M.; Ganser, Arnold

doi:10.1159/000059321

Cited by 15 publications

(11 citation statements)

References 127 publications

(156 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, aminophostine, 15 to 30 minutes before each radiotherapy session, for six to 7.5 weeks, stimulates the proliferation of basal cells and tissue repair (28) . Satisfactory results are also noticeable with the use of silver nitrate (28) , steroids, E vitamin and oral supplementation with glutamine (29)(30)(31)(32) .…”

Section: Treatmentmentioning

confidence: 99%

Repercussões da radioterapia na região orofacial e seu tratamento

2011

View full text Add to dashboard Cite

A radioterapia em região de cabeça e pescoço provoca inúmeras sequelas ao paciente irradiado, afetando o sistema estomatognático e com repercussões sistêmicas importantes. As sequelas da radiação ionizante podem ser extensas e, algumas vezes, permanentes, em especial nas glândulas salivares e no tecido ósseo. É relevante que o cirurgião dentista tenha conhecimento das reações adversas e das formas adequadas de prevenção e tratamento para amenizar o desconforto e melhorar a condição de vida do paciente irradiado. Portanto, a conscientização e motivação deste paciente, com a promoção de saúde oral através da adequação do meio bucal e orientações sobre ações preventivas, são essenciais para se obter o melhor prognóstico.

show abstract

Section: Treatmentmentioning

confidence: 99%

Repercussões da radioterapia na região orofacial e seu tratamento

2011

View full text Add to dashboard Cite

show abstract

“…Oral mucositis is a side effect of cancer therapy that occurs with a high frequency in patients receiving certain chemotherapeutic regimes or radiation for head and neck cancer [170]. It causes difficulties in eating, drinking and swallowing, but most importantly may preclude cancer patients from receiving their optimal course of therapy and increase the risk of infection and sepsis.…”

Section: Reducing the Side Effects Of Cancer Therapy With Fgfsmentioning

confidence: 99%

Fibroblast growth factors in cancer: therapeutic possibilities

Jeffers¹,

LaRochelle²,

Lichenstein³

2002

Expert Opinion on Therapeutic Targets

View full text Add to dashboard Cite

The fibroblast growth factor (FGF) family of signalling molecules and its receptors (FGFRs) contribute to normal developmental and physiological processes. However, the subversion of this powerful growth stimulatory pathway has been implicated in the generation of a variety of pathological conditions. This review focuses on the role of FGF/FGFRs in cancer. The case will be made that this signalling pathway is associated with and functionally important for the growth of some human tumours. As such, FGF/FGFRs can be viewed as rational therapeutic oncology targets and strategies used to inhibit these molecules are discussed. The therapeutic exploitation of tumour-associated FGFR expression to deliver toxins or antiproliferative signals to tumour cells is also reviewed, as is the use of FGFs as protein therapeutics to alleviate the side effects of cancer therapy.

show abstract

“…Mucositis or inflammation of the oral mucosa is a painful and dose-limiting complication that occurs after high-dose chemotherapy (Blijlevens et al 2000). The management of oral mucositis and the inflammation that also affects esophageal, gastric and intestinal mucosa varies from center to center and optimal treatments are still not clarified (Biron et al 2000;Rosenthal et al 2000). Therapies in practice and those under investigation are directed at inflammatory, epithelial, ulcerative and healing phases of mucositis (Blijlevens et al 2000;Biron et al 2000;Rosenthal et al 2000).…”

Section: Effect Of Glutamine Supplementation On Mucositis Aftermentioning

confidence: 99%

“…Therapies under investigation include cryotherapy, cytoprotection (e.g. with prostaglandin E 2 ), epithelial cell protective factors and agents that may accelerate epithelial restitution (growth factors) and use of antiseptics and antibiotics to decrease secondary infection of denuded mucosal (Blijlevens et al 2000;Biron et al 2000;Rosenthal et al 2000).…”

Section: Effect Of Glutamine Supplementation On Mucositis Aftermentioning

confidence: 99%

Glutamine supplementation in bone marrow transplantation

Ziegler

2002

Br J Nutr

View full text Add to dashboard Cite

An increasing number of clinical investigations have focused on supplementation of specialized enteral and parenteral nutrition with the amino acid glutamine. This interest derives from strong evidence in animal models and emerging clinical data on the efficacy of glutamine administration following chemotherapy, trauma, sepsis and other catabolic conditions. Glutamine has proteinanabolic effects in stressed patients and, among many key metabolic functions, is used as a major fuel/substrate by cells of the gastrointestinal epithelium and the immune system. These effects may be particularly advantageous in patients undergoing bone marrow transplantation (BMT), who exhibit post-transplant body protein wasting, gut mucosal injury and immunodeficiency. Studies to date indicate that enteral and parenteral glutamine supplementation is well tolerated and potentially efficacious after high-dose chemotherapy or BMT for cancer treatment.Although not all studies demonstrate benefits, sufficient positive data have been published to suggest that this nutrient should be considered as adjunctive metabolic support of some individuals undergoing marrow transplant. However, BMT is a rapidly evolving clinical procedure with regard to the conditioning and supportive protocols utilized. Thus, additional randomized, double-blind, controlled clinical trials are indicated to define the efficacy of glutamine with current BMT regimens.

show abstract

New Strategies in the Treatment and Prophylaxis of Chemo- and Radiotherapy-Induced Oral Mucositis

Cited by 15 publications

References 127 publications

Repercussões da radioterapia na região orofacial e seu tratamento

Repercussões da radioterapia na região orofacial e seu tratamento

Fibroblast growth factors in cancer: therapeutic possibilities

Glutamine supplementation in bone marrow transplantation

Contact Info

Product

Resources

About