2019
DOI: 10.1016/j.transproceed.2018.10.028
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New Strategy of Acute Graft-vs-Host Disease: Investigation of a Reduced Dose of Antithymocyte Globulin in Haploidentical Hematopoietic Stem Cell Transplantation

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Cited by 1 publication
(1 citation statement)
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“…Transplanted HSCs must reach and seed specific niches in recipient bone marrow (BM), a process termed "homing and engraftment." 1 Although recent advances in HSCT, such as milder conditioning regimens and haplotransplantation, have improved on recognized limitations of HSCT, including donor availability and conditioning-related morbidities, [2][3][4][5][6] more could be done to improve the safety, efficacy, and accessibility of this critical therapy. For example, ex vivo manipulation of HSCs for gene therapy compromises their homing and engraftment, [7][8][9][10] small cell numbers limit the utility of cord blood HSCs as a source for transplantation, [11][12][13][14][15][16] and underrepresentation of minorities on national bone marrow registries contributes significantly to limited donor access for these groups.…”
Section: Introductionmentioning
confidence: 99%
“…Transplanted HSCs must reach and seed specific niches in recipient bone marrow (BM), a process termed "homing and engraftment." 1 Although recent advances in HSCT, such as milder conditioning regimens and haplotransplantation, have improved on recognized limitations of HSCT, including donor availability and conditioning-related morbidities, [2][3][4][5][6] more could be done to improve the safety, efficacy, and accessibility of this critical therapy. For example, ex vivo manipulation of HSCs for gene therapy compromises their homing and engraftment, [7][8][9][10] small cell numbers limit the utility of cord blood HSCs as a source for transplantation, [11][12][13][14][15][16] and underrepresentation of minorities on national bone marrow registries contributes significantly to limited donor access for these groups.…”
Section: Introductionmentioning
confidence: 99%