New strategy of α- and γ-tocopherol to prevent contrast-induced acute kidney injury in chronic kidney disease patients undergoing elective coronary procedures

Tasanarong, Adis; Vohakiat, Anchalee; Hutayanon, Pisit; Piyayotai, Dilok

doi:10.1093/ndt/gfs525

Cited by 61 publications

(75 citation statements)

References 42 publications

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“…While the protective effect of vitamin E against AKI was first reported over 20 years ago, since then the therapeutic action of vitamin E has been demonstrated in many different animals (including mice [16,21], rats [13,22,23], rabbits [14], dogs [24], and pigs [25]) by using a variety of modeling methods (including ischemia/reperfusion [14,26,27], cisplatin [25,28], and other methods [13,29,30]), and has even been demonstrated in clinical studies [31,32] (Supplementary Table 1. Detailed information on the AKI models applied in the investigation of the protective effect of vitamin E).…”

Section: Therapeutic Action Of Vitamin E Against Akimentioning

confidence: 99%

“…Prophylaxis adminLVWUDWLRQ ZLWK RUDO Į-WRFRSKHURO RU Ȗ-tocopherol in combination with saline has been shown to be effective against CI-AKI in patients. Moreover, IXUWKHU FOLQLFDO UHVXOWV KDYH LQGLFDWHG WKDW Į-tocopherol produces a more significant effect than Ȗ-tocopherol when compared with the placebo group [31]. Most significantly, although the results of these early human trials still need to be further confirmed through adequately powered randomized controlled studies, these clinical studies mark the beginning of an extraordinary period in vitamin E-based therapy against AKI.…”

Section: Therapeutic Action Of Vitamin E Against Akimentioning

confidence: 99%

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Protective effect of vitamin E against acute kidney injury

Liu

Feng

Wang

et al. 2015

BME

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Abstract. It has been well-known for many years now that vitamin E is an essential nutrient; however, some of the physiological functions of this vitamin are still far from being understood. In recent years, a series of preclinical and clinical studies proposed a protective role of vitamin E on acute kidney injury (AKI), which has a high morbidity rate and mortality rate in clinical investigations. Based on the benefits associated with vitamin E, such as strong antioxidant function, low toxicity, rare side-effects, and low cost, this therapy strategy has garnered an extensive amount of interest in the scientific community for the development of new therapy modes against AKI. In this review, a concise overview of the application of vitamin E in the treatment of AKI is provided as well as a summary of a series of published data regarding the combination therapy modes and detailed therapy mechanisms of vitamin E-based therapy against AKI. At present, there are critical points of this therapy mode that are still in need of further clarification, meaning the current understanding of the role of vitamin E in the treatment of AKI remains incomplete. However, the development of more reliable pharmacological or biotechnical strategies with vitamin E for the eventual treatment of patients with AKI may guide the next chapter of vitamin E research.

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Section: Therapeutic Action Of Vitamin E Against Akimentioning

confidence: 99%

Section: Therapeutic Action Of Vitamin E Against Akimentioning

confidence: 99%

Protective effect of vitamin E against acute kidney injury

Liu

Feng

Wang

et al. 2015

BME

View full text Add to dashboard Cite

show abstract

“…Su et al had identified 3 randomized trials on vitamin E prophylaxis against CIAKI (3)(4)(5). We pooled the results of these 3 studies (Figure 1) and calculated a pooled estimate of RR = 0.38 (95% CI 0.24-0.62), indicating that vitamin E significantly prevented CIAKI.…”

Section: To the Editormentioning

confidence: 97%

Vitamins E and C May Differ in Their Effect on Contrast-Induced Acute Kidney Injury

Rezaei

Hemilä

2017

American Journal of Kidney Diseases

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“…Bu konuda yapılan in vitro bir çalışmada böbrek hücresinde, EPA ve DHA'nın, PPARγ bağımlı bir yolak üzerinden, nükleer faktör kappa b (NF-κB) aktivasyonunu ve MCP-1 ekspresyonunu anlamlı şekilde azalttığı gösterilmiştir (52). Kronik böbrek hastalarında (son evre hariç) koroner girişim sonrasında gelişebilecek akut böbrek hasarının önlenmesinde α-tokoferol ve γ-tokoferol suplemantasyonunun anlamlı etkisinin olduğu bir çalışmada bildirilmiştir (61)…”

Section: Türk Nefroloji Diyaliz Ve Transplantasyon Dergisi Turkish Neunclassified

Kronik Böbrek Hastalığında Renal İnflamasyon ve Bazı Güncel Diyet Bileşenleri İlişkisi

Öztürk¹,

Nergiz-Unal²

2018

Turk Neph Dial Transpl

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ÖZKronik böbrek hastalığı, glomerüler filtrasyonun azalmasıyla böbrekte sıvı-solüt dengesinin düzenlen-mesi ve metabolik-endokrin fonksiyonlarda kronik ve ilerleyici bozulma hali olarak tanımlanabilir. Kronik böbrek hastalığı gelişiminde rol alan inflamasyon, kronik böbrek hastalığının sonucu olarak da ortaya çıkabilmekte ve KBH varlığına bağlı mortalite artışının en önemli nedenlerinden biri olarak kabul edilmektedir. İnflamasyon ve diyet etkileşimi ile ilgili yapılan güncel araştırmalar çoklu doymamış yağ asitleri, D vitamini, E vitamini gibi besin ögeleri ile karnitin, lipoik asit, flavanoidler, probiyotikler ve prebiyotikler gibi diğer diyet bileşenlerinin renal inflamasyon sürecindeki olumlu etkilerine işaret etmektedir. Derlemede, olası anti-inflamatuvar bazı diyet bileşenlerinin kronik böbrek hastalığı ile ilişkili inflamasyon üzerine etkileri incelenmiştir. ANAHTAR SÖZCÜKLER: Kronik böbrek hastalığı, Beslenme, İnflamasyon, Diyet ABSTRACTChronic kidney disease can be defined as chronic and progressive deterioration of the regulation of fluid-solute balance and metabolic-endocrine functions of the kidney due to diminishing glomerular filtration. Inflammation in renal disease can develop as a cause or an outcome, and it has been reported in recent studies that inflammation is among the most important causes of disease-related mortality. Investigations on inflammation and diet interactions have shown that the effects of nutrients such as polyunsaturated fatty acids, vitamin D, vitamin E and other dietary components such as carnitine, lipoic acid, flavanoids, probiotics and prebiotics may have positive effects on the renal inflammation process. In this review, the potential anti-inflammatory effects of some current dietary components in chronic kidney disease were studied.

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New strategy of α- and γ-tocopherol to prevent contrast-induced acute kidney injury in chronic kidney disease patients undergoing elective coronary procedures

Abstract: Prophylaxis administration with oral α- or γ-tocopherol in combination with 0.9% saline is effective in protecting against CI-AKI in CKD patients undergoing elective coronary procedures.

Cited by 61 publications

References 42 publications

Protective effect of vitamin E against acute kidney injury

Protective effect of vitamin E against acute kidney injury

Vitamins E and C May Differ in Their Effect on Contrast-Induced Acute Kidney Injury

Kronik Böbrek Hastalığında Renal İnflamasyon ve Bazı Güncel Diyet Bileşenleri İlişkisi

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