New substances for intraocular tamponades: perfluorocarbon liquids, hydrofluorocarbon liquids and hydrofluorocarbon-oligomers in vitreoretinal surgery

Kobuch, Karin; Menz, D.-H.; Hoerauf, Hans; Dresp, J.; Gabel, Virginie

doi:10.1007/s004170100330

Cited by 58 publications

(44 citation statements)

References 31 publications

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“…Experimental use of this tamponade in rabbits showed no droplet formation and a better preservation of retinal vascular architecture. 39 These experimental results lead the authors of this research to conclude that this oligomer was well-tolerated and a promising candidate for use as a tamponade.…”

Section: Eyementioning

confidence: 83%

A new heavy internal tamponade in vitreoretinal surgery: an in vitro study

Tognetto

Lepori

Lapasin

et al. 2008

Eye

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Aim To study the solubility of perfluorohexyloctane (F6H8) in silicone oil (polydimethylsiloxane (PDMS) 1000) and to measure the viscosity and the specific gravity of the mixture obtained (heavy silicone oil or HSO tamponade) to define the ideal ratio of these components. Methods The solubility diagram of the mixture was obtained with the turbidimetric method, indicating the miscibility of F6H8 and silicone oil 1000 at all the useful temperatures. The viscosity was measured in steady shear conditions by using a controlled stress rheometer (Haake RS150) and a double cone/plate (DC 60/4) system, both at 25 and 371C for different volume per cent compositions of the mixture. The specific gravity was measured at 371C using a digital densimeter. Results A mixture of F6H8 30 v% and PDMS 70 v% was found to be transparent and stable at all the useful temperatures. By combining these proportions of the two substances, a resultant density of 1.06 g/cm 3 was obtained. The viscosity of the 30% F6H8 mixture was 203 mPa.s at 251C and 163 mPa.s at 371C respectively. Conclusions The ideal F6H8 and silicone oil mixture can be obtained combining 30% of F6H8 with 70% of silicone oil 1000. This mixture seems to have rheological properties useful for its use as an alternative intraocular heavy tamponade.

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Section: Eyementioning

confidence: 83%

A new heavy internal tamponade in vitreoretinal surgery: an in vitro study

Tognetto

Lepori

Lapasin

et al. 2008

Eye

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“…The second class of heavy liquids are hydrofluorocarbon liquids (HFCL). These were developed because the high specific weight of PFCL was thought to be one cause of the retinal toxicity of PFCL [6]. In HFCL, carbon atoms are only partially fluorinated, and the substances are named systematically according to the number of carbon atoms that are fluorinated or hydrogenated, e.g.…”

Section: Introductionmentioning

confidence: 99%

“…The hydrogenation increases the lipophilic characteristics of HFCL and, therefore, allows solutions with silicone oil. Thus, HFCL have been used to clean intraocular lenses from silicone oil, but they can also induce dense opacification if mixed with silicone oil [6]. To make long-lasting heavy tamponades feasible, the emulsification properties of the substances used have to be reduced.…”

Section: Introductionmentioning

confidence: 99%

“…The viscosity of these liquids is very low (1.4–2.8 mPas), and they have a very high interfacial tension of 53–55 mN/m so that they are unlikely to mix with water. The refractive index is 1.27–1.33 [6], but, as these substances are only used as short-term tamponades, this has no consequences for the patient’s refraction.…”

Section: Introductionmentioning

confidence: 99%

“…The interfacial tension with water is 35 mN/m and the refractive index 1.33 [6]. The viscosity of these substances reaches values between 90 mPas for OL62 LV and 1,750 mPas for OL62 HV.…”

Section: Introductionmentioning

confidence: 99%

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Long-Lasting Endotamponades in Vitreoretinal Surgery

Wagenfeld

Zeitz²,

Skevas³

et al. 2010

Ophthalmologica

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In modern vitreoretinal surgery, a variety of long-lasting endotamponades is available. These endotamponades differ in physical and chemical properties and their usage is based on certain pathological and surgical considerations. With modern endotamponades the treatment and prognosis for some severe diseases of the posterior segment was improved. Besides these supportive features of new endotamponades, the surgeon has to keep in mind that certain steps, like a complete removal of the vitreous and of any traction, are crucial for the success of an operation and that the most supportive step for the retina is complete endotamponade. This review gives an overview of longlasting endotampoandes in vitreoretinal surgery and of the indications for their usage.

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Perfluorohexyloctane (F6H8) induces structural modifications and increases apoptosis in rat primary retinal cultures

et al. 2003

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The effects of perfluorohexyloctane (F6H8), recently investigated as a long-term artificial vitreous substitute, were studied in vitro, with the use of rat retinal cultures seeded on microporous inserts that allow the cell layer to be in contact with the material to be tested, on the apical side, and with the nutrient medium, on the basal side. After 72 h of treatment with F6H8, retinal cultures lost the characteristic two-layered organization with glial cells at the bottom and neuronal cells on top of them. They appeared to be composed of only one layer of polyhedrical, flattened, and disconnected cells. TUNEL assay revealed an evident increase in the percentage of apoptotic cells in F6H8-treated cultures (30.1 +/- 4.5), compared to control (10.3 +/- 2.6) and perfluoroctane-treated cultures (10.1 +/- 1.7). Immunolabeling of MAP-2, a protein of neuronal cytoskeleton, evidenced a marked loss of neurites. The results suggest that F6H8 is harmful to retinal cells in vitro and can therefore be potentially noxious to the retina as an artificial vitreous substitute.

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New substances for intraocular tamponades: perfluorocarbon liquids, hydrofluorocarbon liquids and hydrofluorocarbon-oligomers in vitreoretinal surgery

Cited by 58 publications

References 31 publications

A new heavy internal tamponade in vitreoretinal surgery: an in vitro study

A new heavy internal tamponade in vitreoretinal surgery: an in vitro study

Long-Lasting Endotamponades in Vitreoretinal Surgery

Perfluorohexyloctane (F6H8) induces structural modifications and increases apoptosis in rat primary retinal cultures

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