New Substituted Derivatives of Benzopyran and Chromone

Pochat, Francis; L'Haridon, P.

doi:10.1080/00397919808003064

Cited by 7 publications

(3 citation statements)

References 6 publications

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“…The synthesis of chromones via the condensation of methyl salicylate with bromocrotononitrile derivatives, and subsequent cyclization of the vinyl ether intermediate in basic (NaH) medium, has been also described (Scheme C) . Functionalized 2-amino-3-cyano-4-chromones have also been obtained by a one-pot procedure by which acetylsalicylic acid derivatives react with N -hydroxybenzotriazole (HOBt) and malononitrile under basic conditions (NaH).…”

Section: Methods Of Synthesis Of Simple Chromonesmentioning

confidence: 99%

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Chromone: A Valid Scaffold in Medicinal Chemistry

et al. 2014

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The last few decades have provided stunning progresses in the understanding of physiopathology of several diseases. The remarkable progress in research fields, like genetics, immunology, neurobiology, among others, as well as the advent of more powerful tools, have made it possible to characterize, monitor, and understand far more of the basis of physiology and disease. However, for some diseases the treatment remains a problematic issue as the efforts performed so far were not translated into therapeutic solutions. Notwithstanding the steady increase in the total amount of FCUP

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Section: Methods Of Synthesis Of Simple Chromonesmentioning

confidence: 99%

“…Other applications of salicylic acid derivatives as starting materials have been reported in the literature, namely for the synthesis of chromones via the condensation [ 268] .…”

Section: Synthesis Of Chromones From Phenolsmentioning

confidence: 99%

Chromone: A Valid Scaffold in Medicinal Chemistry

et al. 2014

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“…Typically, chromones can be prepared by the classical synthetic routes, including Claisen condensation [ 13 , 14 ], Baker–Venkataraman [ 15 ], Kostanecki–Robinson reaction [ 16 , 17 ], benzopyrylium salts [ 18 , 19 , 20 ], and Vilsmeier–Haack reaction [ 21 , 22 ], utilizing ortho -hydroxyarylalkylketones as starting materials. In addition, phenols, salicylic acid, and derivatives have also been used to synthesize chromones via the Simonis [ 23 , 24 ] and Ruhemann [ 25 ] reactions and others [ 26 , 27 , 28 , 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Radical-Induced Cascade Annulation/Hydrocarbonylation for Construction of 2-Aryl-4H-chromen-4-ones

Liu

et al. 2022

Molecules

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A robust metal- and solvent-free cascade radical-induced C-N cleavage/intramolecular 6-endo-dig annulation/hydrocarbonylation for the synthesis of the valuable 2-aryl-4H-chromen-4-ones is described. This practical synthesis strategy utilizes propargylamines and air as the oxygen source and green carbonylation reagent, in which propargylamines are activated by the inexpensive and available dimethyl 2,2′-azobis(2-methylpropionate) (AIBME) and (PhSe)2 as the radical initiators. This simple and green protocol features wide substrate adaptability, good functional group tolerance, and amenability to scaling up and derivatizations.

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