New superior bioactive metal complexes of ligand with N, O donor atoms bearing sulfadiazine moiety: Physicochemical study and thermal behavior for chemotherapeutic application

Hassan, Marwa M; Nasr, Sami Mohamed; Razek, Samar Ebrahim Abd-El; Abdel‐Aziz, Mohamed S.; El-Gamasy, Sabreen Mohamed

doi:10.1016/j.arabjc.2020.08.010

Cited by 14 publications

(6 citation statements)

References 27 publications

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“…The magnetic moment measurement of 5.76 BM for complex 2 is in close agreement with the expected high spin manganese (II) in the octahedral environment 39 . In complex 3 , the found magnetic moment value is 4.91 B. M which is in the described range of high spin cobalt (II) octrahedral complexes 40,41 . The magnetic moment value of 3.72 B. M for complex 4 , suggested the octahedral geometry and the 1.87 B.M.…”

Section: Resultssupporting

confidence: 81%

See 1 more Smart Citation

Piroxicam analogue metal complexes: Synthesis, crystal structures, molecular modeling and biological studies

Zainab,

Ashraf,

Siddiqui

et al. 2024

Applied Organom Chemis

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In recent decades, metal‐based drugs have gained considerable attention all over the world because of their enhanced therapeutic potential. The piroxicam analogue, that is, 2‐Benzyl‐4‐hydroxy‐1,1‐dioxo‐1,2‐dihydro‐1λ6‐benzo [e][1,2] thiazine‐3‐carboxylic acid pyridin‐2‐yl amide 1 was synthesized and coupled with Mn (II), Co (II), Ni (II), Cu (II) and Zn (II) metal ions to isolate complexes 2–6. The N,O‐bidentate chelator coordinated with the metal center via pyridyl nitrogen and amide oxygen atoms by forming six‐membered ring system. Several analytical techniques like UV–Vis, FT‐IR, 1H NMR, magnetic susceptibility, and elemental analysis were performed to confirm the syntheses of the octahedral complexes. The conductance measurement was employed to determine the non‐electrolytic nature of the complexes. The molecular structures of manganese (II) 2, cobalt (II) 3, and zinc (II) 6, complexes were confirmed by single beam X‐ray crystallography revealing the monoclinic crystal system with P21/c space group. The crystallographic data was utilized to carry out the DFT studies, which were found in line with the experimental data. The antioxidant (DPPH, FRAP) and antibacterial activities were performed to determine the therapeutic potential of these synthesized compounds. These studies indicated that understudied compounds have potential as therapeutic agents and they may be used as drug candidates in the future. The in‐silico studies also aligned with the in‐vitro potential of the targeted compounds.

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Section: Resultssupporting

confidence: 81%

“…39 In complex 3, the found magnetic moment value is 4.91 B. M which is in the described range of high spin cobalt (II) octrahedral complexes. 40,41 The magnetic moment value of 3.72 B. M for complex 4, suggested the octahedral geometry and the 1.87 B.M. value falls in the normal range of octahedral copper complexes.…”

Section: Magnetic Susceptibility Measurementsmentioning

confidence: 96%

Piroxicam analogue metal complexes: Synthesis, crystal structures, molecular modeling and biological studies

Zainab,

Ashraf,

Siddiqui

et al. 2024

Applied Organom Chemis

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“…The six-coordinate Co1 center possesses a distorted octahedral {CoN2O4} envir populated by four carboxyl oxygen atoms from three μ3-Hdpna 2 linkers and tw nors from two different μ-dpey moieties. The bond lengths of Co-O and Co 2.017(2)-2.246(2) and 2.154(3)-2.156(2) Å, respectively; these are within the ranges observed in related Co(II) compounds [7,13]. In 1, the Hdpna 2 ligand t coordination model (Scheme 2) with two COO − groups being bidentate or brid dentate, while the nitrogen site of the pyridine ring remains uncoordinated.…”

Section: Crystal Structure Ofsupporting

confidence: 69%

“…Nowadays, a growing number of transition metal coordination polymers (CPs) serve as crystalline materials because their various topologies and structures [1][2][3]. These functional compounds have prospective applications in gas separation and adsorption [4][5][6], the development of sensors [7,8] and heterogeneous catalysts [9][10][11], and many other fields [12][13][14]. Solvothermal and hydrothermal synthetic methods are widely used in the assembly of coordination polymers [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Hydrothermal Assembly, Structural Multiplicity, and Catalytic Knoevenagel Condensation Reaction of a Series of Coordination Polymers Based on a Pyridine-Tricarboxylic Acid

Kang,

Ren,

Mei

et al. 2023

Molecules

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A pyridine-tricarboxylic acid, 5-(3′,5′-dicarboxylphenyl)nicotinic acid (H3dpna), was employed as a adjustable block to assemble a series of coordination polymers under hydrothermal conditions. The seven new coordination polymers were formulated as [Co(μ3-Hdpna)(μ-dpey)]n·nH2O (1), [Zn4.5(μ6-dpna)3(phen)3]n (2), [Co1.5(μ6-dpna)(2,2′-bipy)]n (3), [Zn1.5(μ6-dpna)(2,2′-bipy)]n (4), [Co3(μ3-dpna)2(4,4′-bipy)2(H2O)8]n·2nH2O (5),[Co(bpb)2(H2O)4]n[Co2(μ3-dpna)2(H2O)4]n·3nH2O (6), and [Mn1.5(μ6-dpna)(μ-dpea)]n (7), wherein 1,2-di(4-pyridyl)ethylene (dpey), 1,10-phenanthroline (phen), 2,2′-bipyridine(2,2′-bipy),4,4′-bipyridine(4,4′-bipy),1,4-bis(pyrid-4-yl)benzene (bpb), and 1,2-di(4-pyridyl)ethane (dpea) were employed as auxiliary ligands. The structural variation of polymers 1–7 spans the range from a 2D sheet (1–4, 6, and 7) to a 3D metal–organic framework (MOF, 5). Polymers 1–7 were investigated as heterogeneous catalysts in the Knoevenagel condensation reaction, leading to high condensation product yields (up to 100%) under optimized conditions. Various reaction conditions, substrate scope, and catalyst recycling were also researched. This work broadens the application of H3dpna as a versatile tricarboxylate block for the fabrication of functional coordination polymers.

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“…[41] The coordinated and hydrated water molecules were reflected in the range 3,628-3,437 cm À1. [ [42]]…”

Section: Synthesesmentioning

confidence: 99%

Antibacterial metal complexes of o‐sulfamoylbenzoic acid: Synthesis, characterization, and DFT study

Siddiqui

Khalid

Ashraf

et al. 2021

Applied Organom Chemis

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Herein, antibacterial transition metal complexes of ML 2 type having osulfamoylbenzoic acid as ligand were synthesized from saccharin. All characterization techniques confirmed the syntheses of non-ionic transition metal Mn II (3), Co II (4), Ni II (5), Cu II (6), and Zn II (7) complexes, where monoanionic o-sulfamoylbenzoic acid acts as a weak field ligand. The FT-IR, elemental analysis, and magnetic susceptibility studies suggested octahedral and square pyramidal geometries depending on the nature of metal ions. Biological activity of these complexes was studied by using six bacterial strains.Interestingly, the bacterial strains Escherichia coli and Klebsiella aerogenes were inhibited to the maximum level by 6. Among aforementioned five complexes, 4 and 6 were found in crystalline form. Apart from experimental study, DFT study was also performed for entitled complexes at the M06/6-311G(d,p) level. A comparative investigation was performed for geometrical parameters and vibrational analysis, and an agreement was obtained. Natural bonding orbital investigations expressed larger value of stabilization energy 21 kcal/mol for 3, 4, and 6 while 42 kcal/mol for 5 and 7. Furthermore, global reactivity findings also disclosed higher value of hardness (2.44-3.09 eV) for entitled chromophores, hence, showed more stability. Moreover, frontier molecular orbital This research work is attributed to the late Prof. Hamid Latif Siddiqui.

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New superior bioactive metal complexes of ligand with N, O donor atoms bearing sulfadiazine moiety: Physicochemical study and thermal behavior for chemotherapeutic application

Cited by 14 publications

References 27 publications

Piroxicam analogue metal complexes: Synthesis, crystal structures, molecular modeling and biological studies

Piroxicam analogue metal complexes: Synthesis, crystal structures, molecular modeling and biological studies

Hydrothermal Assembly, Structural Multiplicity, and Catalytic Knoevenagel Condensation Reaction of a Series of Coordination Polymers Based on a Pyridine-Tricarboxylic Acid

Antibacterial metal complexes of o‐sulfamoylbenzoic acid: Synthesis, characterization, and DFT study

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