New syntheses of aromatic acid chlorides from trichloromethylarenes. 1. Reaction with sulfur dioxide

Síntese, avaliação biológica e modelagem molecular de arilfuranos como inibidores da enzima tripanotiona redutase

“…Os arilfuranos 7, 17-19 foram obtidos, utilizando o furano ou furfural e a 4-nitroanilina ou 4-aminobenzonitrila como materiais de partida 9 , de acordo com a metodologia de síntese descrita por Meerwein 29 . Os nitroarilfuranos 7 e 17 foram submetidos à reação de hidrogenação catalítica, utilizando H 2 sob Pd/C, resultando na obtenção dos derivados amino 2 e 8, respectivamente.…”

Copper-catalyzed free-radical C–H arylation of pyrroles

“…During our optimization studies, we assessed various copper catalysts from which Cu(OAc) 2 ÁH 2 O emerged as the best one (entry 5). Although, CuCl 2 was the standard catalyst for the coppercatalyzed Meerwein arylation, 14 it frequently led to Sandmeyer-type side-products contrary to Cu(OAc) 2 ÁH 2 O. 15 The reaction was highly regioselective at C2 provided that an excess of pyrrole 2 was used to avoid the double arylation at C2/C5.…”

Transition Metal‐Mediated Direct CH Arylation of Heteroarenes Involving Aryl Radicals

“…Whilst this mechanism could be acceptable in many cases, it cannot explain why in acetone-free solvents, e.g., water, acetonitrile or NMP, the reaction still takes place nor why using directly CuCl tends to be less efficient than starting with CuCl 2 . [63] On the other hand, the formation of an arenediazonium tetrachlorocup-A C H T U N G T R E N N U N G rate(II) has been suggested when starting from CuCl 2 and arenediazonium chlorides, but this complex was not reduced by acetone. [64] In 2009, another mechanism was proposed and involved the reduction of CuCl 2 into CuCl by the olefinic substrate giving a radical cation.…”