New Synthetic Methodologies for Amphiphilic Multiblock Copolymers of Ethylene Glycol and Propylene Sulfide

Napoli, Alessandro; Tirelli, Nicola; Kilcher, Giona; Hubbell, Jeffrey A.

doi:10.1021/ma0108057

Cited by 141 publications

(140 citation statements)

References 22 publications

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“…The 'one pot' character of the synthesis [34] allows the use of the method by operators with limited skill in organic synthesis. No traces of toxic reagents or solvents are left after the purification.…”

Section: Peg-pps Vesicles Filaments and Micellesmentioning

confidence: 99%

Nanotechnology Advances in Drug Delivery

Velluto¹,

Ricordi²

2017

NanoWorld J

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Drug delivery emerged as a discipline to solve problems associated with the majority of the current drugs, such as poor water solubility, poor physical stability, poor absorption and side effects. Large pharmaceutical companies are investing in drug delivery technologies to find better ways to administer existing drugs rather than designing new products. The secret to a successful drug delivery system, one that allows controlled release over a prolonged period of time, is in the carrier. An ideal drug carrier must be biocompatible, biodegradable, water friendly, selective, easy to prepare, stable, cheap, and finally, ultra-small. Therefore, the interdisciplinary field of nanotechnology and nanomaterials is playing a big role in drug delivery by providing new tools to develop ideal nanocarriers and find appropriate solutions for medical problems. In this review, we briefly recapitulate the history of nanomaterials in drug delivery, explore their unique properties, and report an example of the design and development of polymerbased nanomaterials. We also revisit the most challenging applications of drug delivery for cancer treatment, cell and tissue transplantations and stem cell therapies. Overall, nanotechnology-based drug delivery systems administered by different routes can be considered promising tools to improve patient compliance and achieve better therapeutic outcomes in critical illnesses.

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Section: Peg-pps Vesicles Filaments and Micellesmentioning

confidence: 99%

Nanotechnology Advances in Drug Delivery

Velluto¹,

Ricordi²

2017

NanoWorld J

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“…These include the shell crosslinked, disulfide based cystamine-containing triblock copolymer micelles, the polymer micelles with shells crosslinked via thiol-reducible disulfide bonds and also the block copolymers with hydrophilic PEG tethered to hydrophobic poly(propylene sulfide) via a disulfide bridge [2,[20][21][22][23][24].…”

Section: Redox/thiol Responsive Polymersmentioning

confidence: 99%

“…Disulfide can be converted to thiols by exposure to various reducing agents and/or undergo disulfide exchange in the presence of other thiols (Reproduced with kind permission from Reference [2]). [2,[20][21][22][23][24] Disulfide based cystamine-containing triblock copolymer micelles that were shell crosslinked Block copolymers with hydrophilic PEG tethered to hydrophobic poly(propylene sulfide) via a disulfide bridge…”

Section: Redox/thiol-responsivementioning

confidence: 99%

Responsive Polymers for Crop Protection

et al. 2010

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This review outlines the responsive polymer methods currently in use with their potential application to plant protection and puts forward plant-specific mechanisms as stimuli in newly devised methods for smart release of crop protection agents (CPAs). CPAs include chemicals (fungicides, insecticides, herbicides), biochemicals (antibiotics, RNAbased vaccines for plant viruses), semiochemicals (pheromones, repellents, allomones), microbial pesticides, growth regulators (insect and plant) or micronutrients, all with crop protection effects. This appraisal focuses on emerging uses of polymer nano-encapsulated CPAs. Firstly, the most interesting advances in controlled release methods are critically discussed with their advantages and drawbacks. Secondly, several plant-specific stimulibased smart methods are anticipated for use alongside the polymer nano-or microcapsules. These new CPA release methods are designed to (i) protect plants against infection produced by fungi or bacteria, and (ii) apply micro-nutrients when the plants need it the most. Thus, we foresee (i) the responsive release of nano-encapsulated bioinsecticides regulated by plant stress enzymes, and (ii) the delivery of micro-nutrients synchronized by the nature or intensity of plant root exudates. Such continued advances of nano-scale smart polymer-based CPAs for the protection of crops herald a "small revolution" for the benefit of sustainable agriculture.Keywords: responsive polymers; crop protection agent (CPA); CPA nanocapsule; nanoscience; nanotechnology; plant-specific stimuli; intelligent self-regulated release OPEN ACCESSPolymers 2010, 2 230 Glossary of TermsAllomone: a pheromone that induces a behavioral or physiological change in a member of another species that is of benefit to the producer. Bio-insecticide: the natural substance made and used for eliminating plant-eating insects. Cuticle: the layer of cutin (waxy waterproof substance, consisting of derivatives of fatty acids) covering the epidermis of the aerial parts of plants. Elicitor: a substance that induces the defense mechanisms in higher plants. Epidermis: the outer protective layer of plant cells. Parasitic plant: a plant that derives some or all of its sustenance from another plant. Perennial plant: a plant that lives for more than two years. Phloem: a plant tissue that conducts organic nutrients substances to all parts of the plant. Phytopathogen: an organism that causes a disease in a plant. RNA-based vaccines for plant viruses: Double-stranded RNA (dsRNA) is a RNA with two complementary strands, which is converted to small interfering (siRNA), involved in the RNA interference (RNAi) pathway, including plant viruses RNA silencing. Root exudate: any substance released through the pores of a diseased or injured plant root.

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“…1,2 Among these copolymers, stimuliresponsive copolymers are of particular importance, because of their promising potential applications in biomedicine. Recently, considerable efforts were devoted to the development of new polymers which were responsive to various internal and external stimuli, such as pH, [3][4][5][6] temperature, [7][8][9] light, [10][11][12] as well as voltage.…”

mentioning

confidence: 99%

“…After a welldefined characterization for the diblock copolymer structures via FTIR, 1 H NMR and SEC/MALLS, the self-assemble behaviors and the pH-triggered phase transition processes were investigated using UV-vis spectroscopy, DLS, SLS, TEM and fluorescence spectrophotometer.…”

mentioning

confidence: 99%

Amphiphilic diblock copolymers bearing pendant aromatic acetal groups: Synthesis and tunable pH‐triggered assembly/disassembly transition behavior

Zhang

Fan

Zhang

et al. 2015

J. Polym. Sci. Part A: Polym. Chem.

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A novel aromatic acetal-based acid-labile monomer 2-phenyl-5-ethyl-5-acryloxymethyl-1,3-dioxacyclohexane (HEDPA) was synthesized and polymerized by reversible addition fragmentation chain transfer (RAFT) polymerization using alkynyl functional chain transfer agent (CTA-Alk). Afterward, a series of amphiphilic diblock copolymers composed of fixed hydrophobic poly(2-phenyl-5-ethyl-5-acryloxymethyl-1,3-dioxacyclohexane) (PDAEP) segments and various lengths of hydrophilic mPEG segments were prepared through click reaction between alkynyl-terminated PDAEP and azido-terminated mPEG. The self-assembly behaviors of the diblock copolymers were investigated by dynamic light scattering (DLS), transmission electron microscopy (TEM), fluorescence spectroscopy, and 1 H NMR. These results indicated that the diblock copolymers could self-assemble into nano-sized micelles with PDAEP cores and PEG coronas in aqueous solution. DLS, fluorescence spectroscopy and UV-vis spectroscopy were used to monitor the pH-triggered assembly/disassembly transition of the micelles. These results showed that the assembly/disassembly transition behaviors of the diblock copolymers micelles can be adjusted by changing the lengths of the mPEG segments.

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New Synthetic Methodologies for Amphiphilic Multiblock Copolymers of Ethylene Glycol and Propylene Sulfide

Cited by 141 publications

References 22 publications

Nanotechnology Advances in Drug Delivery

Nanotechnology Advances in Drug Delivery

Responsive Polymers for Crop Protection

Amphiphilic diblock copolymers bearing pendant aromatic acetal groups: Synthesis and tunable pH‐triggered assembly/disassembly transition behavior

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