New synthetic PEKK/bioceramic hybrids and their surface sulfonation counterparts have increased cellular osteogenic capacity and promoted osseointegration

Gu, Pengzhen; Wen, Zhijing; Liu, Bao; Wang, Yibin; Ouyang, Pengrong; Lu, Teng; Li, Jialiang; Li, Jiaxi; Meng, Jian; Li, Na; Zhang, Xiangcheng; Wu, Jian; He, Xijing

doi:10.1016/j.matdes.2022.111283

Cited by 2 publications

(1 citation statement)

References 45 publications

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“…Mature osteoblasts secrete a mineral matrix, which leads to calcium deposition. Extracellular matrix mineralization was detected using a quantitative method [ 26 , 27 ]. The mineralized nodules were solubilized in 10 % hexadecylpyridinium chloride sodium phosphate solution (Solarbio Science & Technology), incubated at room temperature for 10 min, and the absorbance was measured at 562 nm (n = 3).…”

Section: Methodsmentioning

confidence: 99%

Integrated evaluation of biomechanical and biological properties of the biomimetic structural bone scaffold: Biomechanics, simulation analysis, and osteogenesis

Li,

Yang,

Sun

et al. 2024

Materials Today Bio

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Section: Methodsmentioning

confidence: 99%

Integrated evaluation of biomechanical and biological properties of the biomimetic structural bone scaffold: Biomechanics, simulation analysis, and osteogenesis

Li,

Yang,

Sun

et al. 2024

Materials Today Bio

Self Cite

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Effect of Structure on Osteogenesis of Bone Scaffold: Simulation Analysis Based on Mechanobiology and Animal Experiment Verification

Li,

Sun,

Wei

et al. 2024

Bioengineering

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Porous scaffolds, whose mechanical and biological properties are greatly affected by structure, are new treatments for bone defects. Since bone repair is related to biomechanics, analyzing the osteogenesis in scaffolds based on mechanical stimulation may become a more effective method than traditional biological experiments. A tissue regeneration algorithm based on mechanical regulation theory was implemented in this study to evaluate the osteogenesis of classical scaffolds (Gyroid, I-WP, and Diamond). In vivo experiments were used to verify and supplement the simulation results. Different approaches to describing osteogenesis were discussed. Bone formation was more obvious inside the Gyroid scaffold and outside the I-WP scaffold, while the new bone was more sufficient and evenly distributed in the Diamond scaffold. The osteogenesis pattern of the bone scaffold in the simulation analysis was consistent with the results of animal experiments, and the bone volume calculated by the tissue fraction threshold method and the elastic modulus threshold method was very similar to the in vivo experiment. The mechanical responses mediated by structure affect the osteogenesis of bone scaffolds. This study provided and confirmed a simulation analysis method based on mechanical regulation theory, which is more efficient and economical for analyzing tissue healing in bioengineering.

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New synthetic PEKK/bioceramic hybrids and their surface sulfonation counterparts have increased cellular osteogenic capacity and promoted osseointegration

Cited by 2 publications

References 45 publications

Integrated evaluation of biomechanical and biological properties of the biomimetic structural bone scaffold: Biomechanics, simulation analysis, and osteogenesis

Integrated evaluation of biomechanical and biological properties of the biomimetic structural bone scaffold: Biomechanics, simulation analysis, and osteogenesis

Effect of Structure on Osteogenesis of Bone Scaffold: Simulation Analysis Based on Mechanobiology and Animal Experiment Verification

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