New Taxanes from Taxus brevifolia, 2.

Kingston, David G. I.; Hawkins, Douglas R.; Ovington, Liza G.

doi:10.1021/np50046a018

Cited by 57 publications

(23 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7-e/»/-taxol (7), 14 taxol C, 10-deacetyltaxol C, 7ß-xylosyl-10-deacetyltaxol (8), 15 taxamairin A (9), 16 taxinine A, 17 14 ß-hydroxytaxusin, 18 5 α-hydroxy-7 ß,9a, 10 ß, 13 cx-tetraacetoxy-4(20),l 1-taxadiene, 1-dehydroxybaccatin-VI, 19 1 ß-dehydroxybaccatin-IV, 20 baccatin-IV, 20 (Table 1) revealed that they contained the same taxoid skeleton except for the cinnamoyl side chain at C-5 in 3 and an acetyl group in l. 11 Further on the basis of HSQC and HMBC analysis, the Ή and 13 C NMR data of 1 were assigned. This C-12(16)-oxido bridge was confirmed from the observation of cross-peaks from Me-18 and H2-I6 to C-ll and C-12 as well as correla tions between H-14 and C-12 in the HMBC spectrum (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…11 and taxumairol R (1, 6 mg). By using the same method, fraction B-4 yielded baccatin VI (7 mg) 19 and taxacin (4 mg), and fraction B-5 yielded baccatin IV (5 mg) 20 and frac tion B-6 gave 7-e/?/-deacetyltaxol (4 mg) and 7-e/?/-taxol (3 mg), 14 respectively. Fraction C (2.48 g) was chromatographed on a Si gel (75 g) column and eluted with w-hexane-acetone (3:2) to give a residue, which was crystallized (w-hexane/ CHCI3, 1:1) to afford pachtaxel (0.81 g).…”

Section: Extraction and Isolationmentioning

confidence: 99%

See 1 more Smart Citation

Taxane Diterpenoids from the Root Bark of Taiwanese Yew Taxus Mairei

Shen

Hung

2000

J Chinese Chemical Soc

View full text Add to dashboard Cite

Nineteen compounds including taxumairol R (1), taxinine M (2), taxacin (3), paclitaxel (4), 10‐deacetyltaxol A (5), 10‐deacetyl‐7‐epi‐taxol (6), 7‐epi‐taxol (7), taxol C, 10‐deacetyltaxol C, 7β‐xylosyl‐10‐deacetyltaxol (8), taxamairin A (9), taxinine A, 14β‐hydroxytaxusin (10), 5α‐hydroxy‐7β,9α,10β, 13α‐tetraacetoxy‐4(20), 11‐taxadiene, 1‐dehydroxybaccatin‐VI, 1β‐dehydroxybaccatin‐IV, baccatin IV, baccatin VI and ponasterone A have been isolated and identified from the root bark of Taxus mairei. Among them, compound 1 was a new taxoid and compounds 11 and 7β‐xylosyl‐10‐deacetyltaxol pentaacetate were new derivatives prepared from 14β‐hydroxytaxusin (10) and 8, respectively. Their structures and assignment were established on the basis of 2D‐NMR analysis and chemical methods.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Extraction and Isolationmentioning

confidence: 99%

Taxane Diterpenoids from the Root Bark of Taiwanese Yew Taxus Mairei

Shen

Hung

2000

J Chinese Chemical Soc

View full text Add to dashboard Cite

show abstract

“…Traditional medicinal plants have received considerable attention because their bioactive components may lead to new drug discoveries. [2–10]…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of hydro-alcoholic extracts of Cucurbita pepo and Solanum nigrum on HepG2 and CT26 cancer cell lines

Shokrzadeh¹,

Azadbakht²,

Ahangar³

et al. 2010

Phcog Mag

View full text Add to dashboard Cite

Plants are used worldwide for the treatment of diseases, and novel drugs continue to be developed through research from plants. There are more than 20,000 species of plants used in traditional medicines, and these are all potential reservoirs for new drugs. Cucurbita pepo has been used in traditional folk medicine to treat cold and alleviate ache. Previous pharmacological tests have shown that it possesses antiviral, anti-inflammatory, and analgesic effects. Also, Solanum nigrum has been used as a diuretic and an antipyretic agent and it has also been used to cure inflammation, edema, mastitis and hepatic cancer. In this investigation, cytotoxicity of specific concentrations of hydro-alcoholic extracts of C. pepo and S. nigrum was studied on normal [Chinese hamster ovarian cells (CHO) and rat fibroblast] and cancer (HepG2 and CT26) cell lines. The cytotoxic effects and IC50 of the extracts on the selected cell lines were studied followed by colonogenic assay method. The results showed that IC50 of S. nigrum extract was significantly lower than that of the C. pepo extract on all four cell lines (P < 0.05). On the other hand, IC50 of S. nigrum extract was significantly higher than the extract of Taxus baccata and Cisplatin, herbal and chemical control positive anticancer compounds, respectively, on all four cell lines (P < 0.05). As a result, it is concluded that the extract of S. nigrum has almost similar cytotoxicity to the extract of T. baccata on cancer cells.

show abstract

“…In such communities, cure for life-threatening disease condition characterized by tumor production is attempted using medicinal plants. In the literature, there a lot of compounds ranging from lignans like 5-methoxypodophyllotoxin[2] to terpenoids like taxol[34] that were originally obtained from natural sources but were later developed to full anticancer agents.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic and growth inhibitory effects of the methanol extract Struchium sparganophora Ktze (Asteraceae) leaves

Ayinde

Agbakwuru

2010

Phcog Mag

View full text Add to dashboard Cite

Background:Global research into medicinal plants used in treating tumor-related ailments has become imperative due to the emergence of various forms of cancer diseases. Usually consumed as a vegetable, Struchium sparganophora is indicated in traditional herbal medicine as one of the plants used in treating tumor-related ailments.Materials and Methods:This claim was examined using bench-top assay methods involving the cytotoxicity of the methanol extract of the leaves to tadpoles of Raniceps ranninus at 10, 20, 40 and 80 μg/ml. Also, the growth inhibitory effects of the extract on guinea corn radicle at 0.5, 1.0, 2 and 4 mg/ml in addition to evaluation of the phytochemical constituents of the leaves was performed. After 24 h, the crude extract and the chloroform fraction produced the highest cytotoxicity of 96.67 ± 4.71%, each at a concentration of 80 μg/ml, while the aqueous fraction produced 100% cytotoxicity at a concentration of 20 μg/ml.Results:The crude extract had an LC50 of 26 μg/ml, the chloroform fraction had 6.25 while the aqueous fraction had 5 μg/ml. On the inhibition of the guinea corn radicle growth, after 96 h, the controls had an average length of 67.81 ± 2.6 mm, whereas the seeds treated with 4 mg/ml of the crude extract had an average length of 35.83 ±1.75 mm, indicating 47.81% reduction in length. At the same concentration, the chloroform and the aqueous fractions showed 32.51 and 43.81% inhibitions. The plant material was observed to contain alkaloids, tannins, saponins and flavonoids, with no traces of anthracene derivatives.Conclusion:The results suggest the probable use of the plant in preparing recipes for tumor-related ailments.

show abstract

New Taxanes from Taxus brevifolia, 2.

Cited by 57 publications

References 6 publications

Taxane Diterpenoids from the Root Bark of Taiwanese Yew Taxus Mairei

Taxane Diterpenoids from the Root Bark of Taiwanese Yew Taxus Mairei

Cytotoxicity of hydro-alcoholic extracts of Cucurbita pepo and Solanum nigrum on HepG2 and CT26 cancer cell lines

Cytotoxic and growth inhibitory effects of the methanol extract Struchium sparganophora Ktze (Asteraceae) leaves

Contact Info

Product

Resources

About