New technologies for burn wound closure and healing—Review of the literature

Atiyeh, Bishara S.; Hayek, Shady N.; Gunn, S. William A.

doi:10.1016/j.burns.2005.08.023

Cited by 184 publications

(87 citation statements)

References 109 publications

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“…24) Increasing amounts of exudates slow both wound contraction and eschar tissue formation down and could initiate microbial infections. Suitable gel formulations should absorb the wound exudates and also keep the moisture on wound surface during treatment.…”

Section: Resultsmentioning

confidence: 99%

Preparation of Fucoidan-Chitosan Hydrogel and Its Application as Burn Healing Accelerator on Rabbits

Sezer

Cevher

Hatıpoğlu

et al. 2008

Biological & Pharmaceutical Bulletin

160

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Burn healing includes a specific biological process related to the general phenomenon of growth and regeneration and the primary objective in burn care is the promotion of rapid wound healing with the best functional results. The principal function of a burn dressing is to provide an optimum healing milieu for natural healing and desirable burn dressing may, therefore, be characterized on the basis of its performance such as; (a) provision of adequate gaseous exchange, (b) provision and maintenance of a moist environment, (c) protection from infections and contamination, (d) absorption of wound fluids and (e) painless and easy removal. 1,2) Hydrogels are ideal biopolymeric pharmaceutical forms for the treatment of skin wounds. They have low interfacial tension, high molecular and oxygen permeability, good moisturizing and mechanical properties that resemble physiological soft tissue. 3,4) For this reasons, polysaccharides, e.g. chitosan, are having hydrogel forming properties have been considered to be advantageous in its application as a wound dressing material. 5) Chitosan, [a (1→4) 2-amino-2-deoxy-b-D-glucan], a unique polysaccharide derived from deacetylation of chitin, has been used in wound treatment owing to its good biocompatibility, biodegradability and accelerated granulation. [6][7][8] On the other hand, fucoidan is a sulphated polyfucose polysaccharide and has attracted considerable biotechnological research interest since the discovery that it possessed anti-coagulant activity similar to that of heparin and also reported to possess other properties including antithrombotic, anti-inflammatory, anti-tumoral and anti-viral effects. 9,10) Many of these effects are thought to be due to its interaction with growth factors such as basic fibroblast growth factor (bFGF) and transforming growth factor-b (TGF-b). Fucoidan may, therefore, be able to modulate growth factordependent pathways in the cell biology of tissue repair. 11) Although a great number of studies on different pharmacological properties of fucoidan and chitosan are present, there is little information on the fucoidan-based system used in burn healing and its only limited with cell culture. 12) The aim of this study was to prepare fucoidan-chitosan hydrogel and to investigate its treatment efficiency on dermal burns on rabbits. MATERIALS AND METHODSMaterials Chitosan (MW 250 kDa, deacetylation degree Ն90%, Pronova A/S, Norway; MW 400 kDa, deacetylation degree Ն60%, Fluka, Germany; MW 750 kDa, deacetylation degree Ն75%, Sigma, U.S.A.), Fucoidan (from Fucus vesiculosus) and lactic acid (85% m/v) purchased from Sigma, U.S.A. All other reagents used were of analytical grade.Preparation of Hydrogels The composition of gel formulations was given in Table 1. Fucoidan was dissolved in 1% m/v lactic acid solution by mechanical shaking at 300 rpm for 1 h. Then chitosan was left to swell in the fucoidan solution overnight to prepare hydrogels. 13) Formulations were kept at 4°C until experiment.Viscosity Measurement The viscosity of hydrogels was determine...

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Section: Resultsmentioning

confidence: 99%

Preparation of Fucoidan-Chitosan Hydrogel and Its Application as Burn Healing Accelerator on Rabbits

Sezer

Cevher

Hatıpoğlu

et al. 2008

Biological & Pharmaceutical Bulletin

160

View full text Add to dashboard Cite

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“…The current literature describes several protocols to perform burn in an experimental model, such as those performed with soldering iron, but there are differences related to both the size of the lesion, temperature and time of exposure. With this, it is observed that the protocols are not yet well established for each degree of impairment to be induced, as some stipulate similar parameters for different degrees of burns [5][6][7] . In this context, this study aimed to propose an experimental protocol, effective, for induction of specifically third-degree burns in rats.…”

Section: ■ Introductionmentioning

confidence: 99%

Alternative animal model for studies of total skin thickness burns

et al. 2017

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Purpose: To present an alternative experimental model of third degree burn of easy reproducibility. Methods: Eighteen male Wister rats were randomly divided into three groups, 6 of which were allocated to each group. A soldering iron coupled to an aluminum plate was used to produce burn, at a temperature of 150ºC, with different exposure times per group. Group 5 (G5) animals were burned at 150°C with exposure time of 5 seconds; Group 10 (G10) the animals were burned at 150°C with exposure time of 10 seconds and group 15 (G15) the animals were burned at 150°C with exposure time of 15 seconds. Results: Histopathological analyzes showed that all three groups had similar morphological characteristics, with total thickness involvement. Conclusion:The technique is effective to reproduce a third degree burn and suggests the temperature of 150ºC with 5 seconds of exposure in order to minimize the risks to the animals.

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“…Pain and the generalized effects on the body experienced by a burn victim are incomparable with other traumas. [1][2][3][4] Initial pathophysiological events associated with burn wound healing include hemostasis and onset of a prolonged inflammatory phase. This leads to the release of several proteins, and formation of edema and exudate at the wound site.…”

Section: Introductionmentioning

confidence: 99%

“…5 Excessive loss of body fluids, accumulation of exudate, and the development of septic shock are reported to be the main reasons for morbidity in millions of burn victims hospitalized each year. 2,3,6 To reduce the discomfort and hospital stay of burn victims, researchers are developing advanced dressing materials that are easy to apply, economical, and readily available. An ideal burn dressing should possess better absorption ability to remove copious exudate, maintain a moist environment for rapid reepithelization, breathability, extensive shielding against microbial intrusion, and have the capability to prevent fluid loss.…”

Section: Introductionmentioning

confidence: 99%

“…An ideal burn dressing should possess better absorption ability to remove copious exudate, maintain a moist environment for rapid reepithelization, breathability, extensive shielding against microbial intrusion, and have the capability to prevent fluid loss. 3,4 Most of the available products like bandages, gauzes, and films lack the aforementioned prerequisites, which increase the demand for the exploration of better substitutes.…”

Section: Introductionmentioning

confidence: 99%

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Fabrication and hemocompatibility assessment of novel polyurethane-based bio-nanofibrous dressing loaded with honey and <em>Carica papaya</em> extract for the management of burn injuries

Balaji

Jaganathan

Ismail

et al. 2016

IJN

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Management of burn injury is an onerous clinical task since it requires continuous monitoring and extensive usage of specialized facilities. Despite rapid improvizations and investments in burn management, >30% of victims hospitalized each year face severe morbidity and mortality. Excessive loss of body fluids, accumulation of exudate, and the development of septic shock are reported to be the main reasons for morbidity in burn victims. To assist burn wound management, a novel polyurethane (PU)-based bio-nanofibrous dressing loaded with honey (HN) and Carica papaya (PA) fruit extract was fabricated using a one-step electrospinning technique. The developed dressing material had a mean fiber diameter of 190±19.93 nm with pore sizes of 4–50 µm to support effective infiltration of nutrients and gas exchange. The successful blending of HN- and PA-based active biomolecules in PU was inferred through changes in surface chemistry. The blend subsequently increased the wettability (14%) and surface energy (24%) of the novel dressing. Ultimately, the presence of hydrophilic biomolecules and high porosity enhanced the water absorption ability of the PU-HN-PA nanofiber samples to 761.67% from 285.13% in PU. Furthermore, the ability of the bio-nanofibrous dressing to support specific protein adsorption (45%), delay thrombus formation, and reduce hemolysis demonstrated its nontoxic and compatible nature with the host tissues. In summary, the excellent physicochemical and hemocompatible properties of the developed PU-HN-PA dressing exhibit its potential in reducing the clinical complications associated with the treatment of burn injuries.

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New technologies for burn wound closure and healing—Review of the literature

Cited by 184 publications

References 109 publications

Preparation of Fucoidan-Chitosan Hydrogel and Its Application as Burn Healing Accelerator on Rabbits

Preparation of Fucoidan-Chitosan Hydrogel and Its Application as Burn Healing Accelerator on Rabbits

Alternative animal model for studies of total skin thickness burns

Fabrication and hemocompatibility assessment of novel polyurethane-based bio-nanofibrous dressing loaded with honey and <em>Carica papaya</em> extract for the management of burn injuries

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