We analyze new GPS data spanning 11 years at 92 stations in eastern Iran. We use these data to analyze the present-day kinematics and the slip rates on most seismogenic faults in eastern Iran. The east Lut, west Lut, Kuhbanan, Anar, Dehshir, and Doruneh faults are confirmed as the major faults and are found to currently slip laterally at 5.6 ± 0.6, 4.4 ± 0.4, 3.6 ± 1.3, 2.0 ± 0.7, 1.4 ± 0.9, and 1.3 ± 0.8 mm/yr, respectively. Slip is right-lateral on the~NS striking east Lut, west Lut, Kuhbanan, Anar, and Dehshir faults and left-lateral on the~EW Doruneh fault. The~NS faults slice the eastern Iranian crust into five blocks that are moving northward at 6-13 mm/yr with respect to the stable Afghan crust at the eastern edge of the collision zone. The collective behavior of the~NS faults might thus allow the Arabian promontory to impinge northward into the Eurasian crust. The~NS faults achieve additional NS shortening by rotating counterclockwise in the horizontal plane, at current rates up to 0.8°/Ma. Modeling the GPS and available geological data with a block rotation model suggests that the rotations have been going on at a similar rate (1 ± 0.4°/Ma) over the last 12 Ma. We identify large strains at the tips of the rotating east Lut, west Lut, and Kuhbanan faults, which we suspect to be responsible for the important historical and instrumental seismicity in those zones.