New tetracyclic tacrine analogs containing pyrano[2,3-c]pyrazole: Efficient synthesis, biological assessment and docking simulation study

Ultrasound mediated green synthesis of pyrano[2,3-c]pyrazoles by using Mn doped ZrO2

“…Pyrazole derivatives have occupied a vital place in drug research because of their various biological and pharmacological activities such as antibacterial (Tanitame et al, 2004), antifungal (Ragavan et al, 2010), antioxidant (Daiane et al, 2014), anticancer , antileishmanial (Faria et al, 2013), hypotensive (Arya et al, 1969), antiallergenic (Parsia et al, 1981) activities etc. Subsequently, several reports for the synthesis of these compounds have been reported including the use of TEA (Litvinov et al, 2009), Per-6-ABCD (Kuppusamy and Kasi, 2010), (Javad et al, 2012), TEABr (Kumar et al, 2007), [Dsim]AlCl 4 (Ahmad et al, 2013), FeNi 3 /SiO 2 /HPGMNP (Mohammad and Seyed, 2013), NaOH/microwave (Kathrotiya and Patel, 2012), Δ/reflux (Zonouz et al, 2012), Δ/CH 3 COOH (Gein et al, 2014), UV (Zou et al, 2011), Microwave (Sharma et al, 2016), Meglumine (Guo et al, 2013), Sproline (Khoobi et al, 2015), ZrO 2 (Saha et al, 2015), Fe 3 O 4 @SiO 2 (Soleimani et al, 2015), 1- (Bodhak et al, 2015) and SnO 2 (Paul et al, 2014). Several of these methods face few or more limitations such as, using expensive reagents and catalysts, strong acidic or basic conditions, toxic reagents, tedious steps, strict reaction conditions, low product yields and long reaction times, which limit their use in practical applications.…”

Novel Tacrine‐Based Pyrano[3’,4’:5,6]pyrano[2,3‐b]quinolinones: Synthesis and Cholinesterase Inhibitory Activity

“…However, extensive use of tacrine was restricted since various side effects such as hepatoxicity were reported . Hence, recent studies have been devoted to the design and synthesis of new and effective tacrine‐based AChE inhibitors . Herein, in continuation of our research program on the synthesis of anti‐ChE compounds , we designed and synthesized novel tacrine analogs, pyrano[3’,4’:5,6]pyrano[2,3‐ b ]quinolinone derivatives (Fig.…”

Acetylcholinesterase inhibition and cytotoxicity of flavonoids and chalcones from Derris indica

“…This disease affects millions of elderly people 1 . Although the aetiology is not well understood, it is believed that the deposition of β-amyloid plaques, a low level of acetylcholine (ACh), formation of neurofibrillary tangles containing tau protein, and oxidative stress may cause this disease 2 .…”