New therapeutic aspects of flavones: The anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin

Li‐Weber, Min

doi:10.1016/j.ctrv.2008.09.005

Cited by 776 publications

(577 citation statements)

References 150 publications

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“…Table 3 shows that the tested seeds' flour most especially watermelon seed's flour follow by pear and benoil seeds' flours are rich in flavonoids. Flavonoids have been reported to possess substantial anti-carcinogenic and anti-mutagenic activities due to their anti-oxidant, antiinflammatory properties and also active in reducing high blood pressure [43,44]. Alkaloids are widely used as basic medicinal agents for their analgesic, antispasmodic and bactericidal effect [45].…”

Section: Results Of the Phytochemical Contents Of Ben Oil (Moringa Olementioning

confidence: 99%

Chemical, Phytochemical and Functional Properties of Selected Seeds’ Flours

O.¹

2014

IJNFS

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Abstract:This study was conducted to investigate qualities of benoil (Moringa oleifera), melon, water melon (Citrullus lanatus L.), pear and pawpaw (Carica papaya) seeds' flours with a view of harnessing them for consumption and possible industrial usage. All the seeds were manually separated from fruit pulps / pod, cleaned, washed with distilled water, air dried, shelled manually, sun dried and then grinded to flours. Chemical contents and functional properties of the resulting seed's flours were determined using standard methods. The results of the proximate and mineral composition indicated that all the seeds' flours contained considerable amounts of protein, fat, carbohydrate, ash, crude fibre, Ca, Na, Fe and P which made them potentials food supplements/food processing especially benoil (Moringa oleifera) and pawpaw seeds' flours. The result shows that watermelon seed flour ranked the highest in terms of all the phytochemical contents determined except its saponin content which was low. Melon seed's flour was low in saponin and tannin contents while its flavonoids and alkaloids contents were high. Saponin content of benoil seed's flours was also high compare to other seeds' flours tested. The tannin and flavonoid contents of benoil seed flour were low while the alkaloids content shows to be low in melon seed flour. However, the cyanide content of all the seeds' flours examined were low generally which shows the seeds' flours are expected to be save for consumption. There were significant (p > 0.05) differences between the samples for all the phytochemical content determined. The seeds' containing all these phytochemicals show that they are highly medicinal and is good for human consumption especially watermelon and benoil (Moringa oleifera) seeds' flours. Also, the investigation showed that all the flours are characterized with good functional properties which mean they could be incorporated into food or use for industrial purpose most especially in infant food formulation. These qualities are indications that great potential exist for these seeds instead of throwing them away as waste after consuming the fruit pulp.

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Section: Results Of the Phytochemical Contents Of Ben Oil (Moringa Olementioning

confidence: 99%

Chemical, Phytochemical and Functional Properties of Selected Seeds’ Flours

O.¹

2014

IJNFS

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“…Both plants have been known and used for a very long time, and their composition and therapeutic effects are described in the literature. Thanks to the biological properties of its components [2], the skullcap, in addition to its antioxidant properties [3][4][5], also has anti-inflammatory [6,7], antimicrobial, antiviral [8,9] and anticancer properties, inhibiting the proliferation of the following tumor cell lines: THP-1 and L1210 murine leukemias, HOS osteosarcoma, SK-MES-1 of lung cancer and SCC-25 of head and neck cancer [10][11][12][13]. Its roots have been used for detoxification of toxins, reducing the total cholesterol level and lowering blood pressure.…”

Section: Introductionmentioning

confidence: 99%

“…Its roots have been used for detoxification of toxins, reducing the total cholesterol level and lowering blood pressure. This herb also possesses cholagogic, diuretic and cathartic actions [6,14,15].…”

Section: Introductionmentioning

confidence: 99%

Interaction of skullcap (Scutellaria baicalensis Georgi) and buckwheat (Fagopyrum esculentum Moench) extracts with lipid bilayers

Pruchnik

Włoch

Żyłka

et al. 2015

J Therm Anal Calorim

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In this paper, we report the effect of skullcap (Scutellaria baicalensis Georgi) root (SR) and buckwheat (Fagopyrum esculentum Moench) husk and stalk (BH and BS) extracts on lipid organization and fluidity of model membranes, examined by monitoring of the thermotropic phase transition of dimyristoylphosphatidylcholine (DMPC) with differential scanning calorimetry, attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and fluorescence spectroscopy. Despite the very high biological activity of these extracts, such a study has not been undertaken previously. Calorimetric results on the thermotropic parameters of DMPC membranes suggest that BH and BS extracts modify them to a greater extent than SR. Fluorescence and ATR-FTIR results confirm that the compounds contained in the SR extract concentrate in the hydrophilic area of the DMPC bilayer, causing an increase in the order of the polar heads of the lipid, and they do not penetrate the hydrophobic area. Compounds contained in the BS and BH extracts also concentrate in the hydrophilic area of the bilayer; however, they partially affect the hydrophobic-hydrophilic interface of the bilayer as well as the upper part of the acyl chain region.

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“…Scutellaria spp. possesses effective anticancer activity and this property is due to some fl avones such as baicalin, baicalein and wogonin (Li-Weber, 2009). Scutellaria extracts are not only cytostatic but also cytotoxic in vitro and in vivo (Scheck et al, 2006;Shang et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Wogonin and neobaicalein from Scutellaria litwinowii roots are apoptotic for HeLa cells

Tayarani-Najarani¹,

Asili²,

Parsaee³

et al. 2012

Rev. bras. farmacogn.

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Chemical investigation on the CH 2 Cl 2 fraction of the Scutellaria litwinowii Bornm. & Sint., Lamiaceace, root extract for the fi rst time resulted in the isolation of wogonin, and neobaicalein. These compounds were evaluated for their cytotoxicity towards HeLa cell lines and lymphocytes. Meanwhile, the role of apoptosis was explored in this toxicity. The cells were cultured in RPMI medium and incubated with different concentrations of isolated fl avonoids. Cell viability was quantifi ed by MTS assay. Apoptotic cells were determined using propidium iodide staining of DNA fragmentation by fl ow cytometry (sub-G1peak). Wogonin, and neobaicalein inhibited the growth of malignant cells in a dose-dependent manner. The IC50 values of 46.62 and 79.34 µM were, respectively, found for neobaicalein and wogonin against HeLa cells after 48 h of treatment. Neobaicalein induced a sub-G1 peak in the fl ow cytometry histogram of treated cells compared to control cells indicating that apoptotic cell death is involved in neobaicalein toxicity. Neobaicalein exerts cytotoxic and pro-apoptotic effects in HeLa cell lines and could be considered as a potential chemotherapeutic agent in cancer treatment.

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New therapeutic aspects of flavones: The anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin

Cited by 776 publications

References 150 publications

Chemical, Phytochemical and Functional Properties of Selected Seeds’ Flours

Chemical, Phytochemical and Functional Properties of Selected Seeds’ Flours

Interaction of skullcap (Scutellaria baicalensis Georgi) and buckwheat (Fagopyrum esculentum Moench) extracts with lipid bilayers

Wogonin and neobaicalein from Scutellaria litwinowii roots are apoptotic for HeLa cells

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