New three-arm amphiphilic and biodegradable block copolymers composed of poly(ε-caprolactone) and poly(N-vinyl-2-pyrrolidone). Synthesis, characterization and self-assembly in aqueous solution

Leiva, Ángel; Quina, Frank H.; Araneda, E.; Gargallo, Ligia; Radić, Deodato

doi:10.1016/j.jcis.2007.01.013

Cited by 25 publications

(25 citation statements)

References 24 publications

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“…The cmc was determined from the plot of the I 1 /I 3 versus copolymer concentration following the sigmoidal Boltzman fitting procedure used by Leiva and col. 33 The partition coefficient of pyrene in copolymer solutions were determined by the method described by Kabanov and col. 34,35 The fraction of hydrophobic pyrene that was incorporated in the micelles (a) was determined from fluorescence intensity at 392 nm, as a function of copolymer concentration, according to the eq 1:…”

Section: Fluorescence Spectroscopy Measurementsmentioning

confidence: 99%

Hierarchically organized micellization of thermoresponsive rod‐coil copolymers based on poly[oligo(ethylene glycol) methacrylate] and poly(ε‐caprolactone)

Luzon

Corrales

Catalina

et al. 2010

J. Polym. Sci. A Polym. Chem.

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A series of amphiphilic triblock copolymers, poly [oligo(ethylene glycol) methacrylate] x -block-poly(e-caprolactone)-block-poly[oligo(ethylene glycol) methacrylate] x , POEGMA Co (x), were synthesized. Formation of hydrophobic domains as cores of the micelles was studied by fluorescence spectroscopy. The critical micelle concentrations in aqueous solution were found to be in the range of circa 10 À6 M. A novel methodology by modulated temperature differential scanning calorimetry was developed to determine critical micelle temperature. A significant concentration dependence of cmt was found. Dynamic light scattering measurements showed a bidispersed size distribution.The micelles showed reversible dispersion/aggregation in response to temperature cycles with lower critical solution temperature between 75 and 85 C. The interplay of the two hydrophobic and one thermoresponsive macromolecular chains offers the chance to more complex morphologies. V C 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: [4909][4910][4911][4912][4913][4914][4915][4916][4917][4918][4919][4920][4921] 2010

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Section: Fluorescence Spectroscopy Measurementsmentioning

confidence: 99%

Hierarchically organized micellization of thermoresponsive rod‐coil copolymers based on poly[oligo(ethylene glycol) methacrylate] and poly(ε‐caprolactone)

Luzon

Corrales

Catalina

et al. 2010

J. Polym. Sci. A Polym. Chem.

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“…8 Ishida et al have reported that although integration of polyethylene glycol (PEG) in the surface of nanoparticles lengthens the circulation time by allowing evasion of the macrophage system, their retention in vivo is still severely impaired. 9 As we previously reported, poly(N-vinylpyrrolidone) (PVP), a good alternative to PEG, 10,11 enhances the in vivo circulation time in that it evades the reticuloendothelial system more efficiently. 12 It was reported that PVP conjugated with tumor necrosis factor-α (TNF-α) showed longer blood circulation time than did PEG-conjugated TNF-α.…”

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confidence: 99%

Efficient delivery of ursolic acid by poly(N-vinylpyrrolidone)-block-poly (ε-caprolactone) nanoparticles for inhibiting the growth of hepatocellular carcinoma in vitro and in vivo

Zhang¹,

Zheng²,

Jing³

et al. 2015

IJN

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Previous reports have shown that ursolic acid (UA), a pentacyclic triterpenoid derived from Catharanthus trichophyllus roots, could inhibit the growth of a series of cancer cells. However, the potential for clinical application of UA is greatly hampered by its poor solubility, whereas the hydrophobicity of UA renders it a promising model drug for nanosized delivery systems. In the current study, we loaded UA into amphiphilic poly(N-vinylpyrrolidone)-block-poly (ε-caprolactone) nanoparticles and performed physiochemical characterization as well as analysis of the releasing capacity. In vitro experiments indicated that UA-NPs inhibited the growth of liver cancer cells and induced cellular apoptosis more efficiently than did free UA. Moreover, UA-NPs significantly delayed tumor growth and localized to the tumor site when compared with the equivalent dose of UA. In addition, both Western blotting and immunohistochemistry suggested that the possible mechanism of the superior efficiency of UA-NPs is mediation by the regulation of apoptosis-related proteins. Therefore, UA-NPs show potential as a promising nanosized drug system for liver cancer therapy.

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“…32 Therefore, water-soluble poly(Nvinylpyrrolidone) (PVP), which is used in many drug delivery systems, is chosen as an alternative option to PEG. 33,34 In our previous studies, PVP modification could lengthen the in vivo circulation time of nanoparticles due to a more effective escape from macrophage systems. 35 Therefore, the drugloaded nanoparticles could be considered a "Trojan horse" designed to deliver anticancer drugs.…”

Section: Introductionmentioning

confidence: 98%

An efficient Trojan delivery of tetrandrine by poly(N-vinylpyrrolidone)-block-poly(ε-caprolactone) (PVP-b-PCL) nanoparticles shows enhanced apoptotic induction of lung cancer cells and inhibition of its migration and invasion

Xu¹,

Hou²,

Zhang³

et al. 2013

IJN

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Earlier studies have demonstrated the promising antitumor effect of tetrandrine (Tet) against a series of cancers. However, the poor solubility of Tet limits its application, while its hydrophobicity makes Tet a potential model drug for nanodelivery systems. We report on a simple way of preparing drug-loaded nanoparticles formed by amphiphilic poly(N-vinylpyrrolidone)-block-poly(ε-caprolactone) (PVP-b-PCL) copolymers with Tet as a model drug. The mean diameters of Tet-loaded PVP-b-PCL nanoparticles (Tet-NPs) were between 110 nm and 125 nm with a negative zeta potential slightly below 0 mV. Tet was incorporated into PVP-b-PCL nanoparticles with high loading efficiency. Different feeding ratios showed different influences on sizes, zeta potentials, and the drug loading efficiencies of Tet-NPs. An in vitro release study shows the sustained release pattern of Tet-NPs. It is shown that the uptake of Tet-NPs is mainly mediated by the endocytosis of nanoparticles, which is more efficient than the filtration of free Tet. Further experiments including fluorescence activated cell sorting and Western blotting indicated that this Trojan strategy of delivering Tet in PVP-b-PCL nanoparticles via endocytosis leads to enhanced induction of apoptosis in the non-small cell lung cancer cell A549 line; enhanced apoptosis is achieved by inhibiting the expression of anti-apoptotic Bcl-2 and Bcl-xL proteins. Moreover, Tet-NPs more efficiently inhibit the ability of cell migration and invasion than free Tet by down-regulating matrix metalloproteinases (MMP)-2 and MMP-9, as well as up-regulating tissue inhibitor of MMP-3 (TIMP-3). Therefore, data from this study not only confirms the potential of Tet in treating lung cancer but also offers an effective way of improving the anticancer efficiency of Tet by nanodrug delivery systems.

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New three-arm amphiphilic and biodegradable block copolymers composed of poly(ε-caprolactone) and poly(N-vinyl-2-pyrrolidone). Synthesis, characterization and self-assembly in aqueous solution

Cited by 25 publications

References 24 publications

Hierarchically organized micellization of thermoresponsive rod‐coil copolymers based on poly[oligo(ethylene glycol) methacrylate] and poly(ε‐caprolactone)

Hierarchically organized micellization of thermoresponsive rod‐coil copolymers based on poly[oligo(ethylene glycol) methacrylate] and poly(ε‐caprolactone)

Efficient delivery of ursolic acid by poly(N-vinylpyrrolidone)-block-poly (ε-caprolactone) nanoparticles for inhibiting the growth of hepatocellular carcinoma in vitro and in vivo

An efficient Trojan delivery of tetrandrine by poly(N-vinylpyrrolidone)-block-poly(ε-caprolactone) (PVP-b-PCL) nanoparticles shows enhanced apoptotic induction of lung cancer cells and inhibition of its migration and invasion

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New three-arm amphiphilic and biodegradable block copolymers composed of poly(ε-caprolactone) and poly(N-vinyl-2-pyrrolidone). Synthesis, characterization and self-assembly in aqueous solution

Cited by 25 publications

References 24 publications

Hierarchically organized micellization of thermoresponsive rod‐coil copolymers based on poly[oligo(ethylene glycol) methacrylate] and poly(ε‐caprolactone)

Hierarchically organized micellization of thermoresponsive rod‐coil copolymers based on poly[oligo(ethylene glycol) methacrylate] and poly(ε‐caprolactone)

Efficient delivery of ursolic acid by poly(N-vinylpyrrolidone)-block-poly (&epsilon;-caprolactone) nanoparticles for inhibiting the growth of hepatocellular carcinoma in vitro and in vivo

An efficient Trojan delivery of tetrandrine by poly(N-vinylpyrrolidone)-block-poly(&epsilon;-caprolactone) (PVP-b-PCL) nanoparticles shows enhanced apoptotic induction of lung cancer cells and inhibition of its migration and invasion

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Efficient delivery of ursolic acid by poly(N-vinylpyrrolidone)-block-poly (ε-caprolactone) nanoparticles for inhibiting the growth of hepatocellular carcinoma in vitro and in vivo

An efficient Trojan delivery of tetrandrine by poly(N-vinylpyrrolidone)-block-poly(ε-caprolactone) (PVP-b-PCL) nanoparticles shows enhanced apoptotic induction of lung cancer cells and inhibition of its migration and invasion