New Ti-6Al-2Nb-2Ta-1Mo alloy as implant biomaterial: In vitro corrosion and in vivo osseointegration evaluations

Trincă, Lucia Carmen; Mareci, Daniel; Solcan, Carmen; Fântânariu, Mircea; Burtan, L. C.; Hrițcu, Luminiţa Diana; Chiruță, Ciprian; Fernández-Mérida, L.; Rodríguez-Raposo, Raquel; Santana, J.J.; Souto, Ricardo M.

doi:10.1016/j.matchemphys.2019.122229

Cited by 19 publications

(6 citation statements)

References 59 publications

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“…Modern beta type alloys contain nontoxic elements and are characterized by high strength, very low elastic modulus, good corrosion resistance, and excellent biocompatibility in comparison to other biometals [4,5]. An examples of modern beta titanium alloys are Ti-5Mo-5Ag [6], Ti-xMo (x-23%-35wt.%) [5,7], Ti14Zr16Nb [4], Ti23Zr25Nb [4], Ti-6Al-2Nb-2Ta-1Mo [8], Ti-15Mo-Zr [9]. It is worth mentioning that a great effort was put into the research and development of Ti-Mo alloys because of their surgical application [10,11].…”

Section: Introductionmentioning

confidence: 99%

Low-Temperature Hydrothermal Treatment Surface Functionalization of the Ultrafine-Grained TiMo Alloys for Medical Applications

2020

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Hydroxyapatite (HAp) is the most widely used material for bio coating. The functional layer can be produced by many methods, however, the most perspective by its utility, easy to scale up, and simplicity aspects remains a hydrothermal treatment approach. In this work, an HAp coating was produced by low-temperature hydrothermal treatment on the ultrafine-grain beta Ti-xMo (x = 23, 27, 35 wt.%) alloys. The proposed surface treatment procedure combines acid etching, alkaline treatment (AT), and finally hydrothermal treatment (HT). The uniqueness of the approach relies on the recognition of the influence of the molar concentration of NaOH (5 M, 7 M, 10 M, 12 M) during the alkaline treatment on the growth of hydroxyapatite crystals. Obtained and modified specimens were examined structurally and microstructurally at every stage of the process. The results show that the layer after AT consist of titanium oxide and phases based on sodium with various phase relations dependent on NaOH concentration and base composition. The AT in 7 M and 10 M enables to obtain the HAp layer, which can be characterized as the most developed in terms of thickness and porosity. Finally, selected coated samples were investigated in terms of surface wettability test managed in time relation, which for the results confirm high hydrophilicity of the surfaces. Conducted research shows that the low-temperature hydrothermal processing could be considered for a possible adaptation in the drug encapsulation and delivery systems.

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Section: Introductionmentioning

confidence: 99%

Low-Temperature Hydrothermal Treatment Surface Functionalization of the Ultrafine-Grained TiMo Alloys for Medical Applications

2020

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“…The effect of anodic polarization on the passive state of nitinol immersed in the test electrolyte was investigated by applying a constant potential of +1.00 V for 15 min. The potential value was selected as to be slightly more positive than the highest anodic polarization recorded in the human body [16], and this value has often been selected as a potential safety threshold value for the in vitro testing of metallic biomaterials [32,33,53,36,59]. Unlike other titanium alloys, for which this anodic polarization value is well below the onset of pitting potential in simulated physiological solutions, passivity breakdown of the oxide layer formed on nitinol occurs at potential values negative to +1.00 V [9] (cf.…”

Section: Resultsmentioning

confidence: 99%

A scanning electrochemical microscopy characterization of the localized corrosion reactions occurring on nitinol in saline solution after anodic polarization

Asserghine

Medvidović‐Kosanović

Stanković

et al. 2020

Sensors and Actuators B: Chemical

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Scanning electrochemical microscopy (SECM) in combined amperometric/potentiometric operation was employed to characterize the electrochemical activity of nitinol biomaterial, prior and after anodic treatment, in 0.1 M NaCl solution. SECM operation in the feedback mode proved that the nitinol surface was homogeneously passive following surface finishing and storage in ambient condition, whereas heterogeneous surface characteristics occurred after the application of anodic polarization even for a limited time. That is, the development of anodic and cathodic sites owing to the onset of localized corrosion processes was detected on the metal surface. Hydrogen gas evolution from localized sites was monitored using SECM in the substrate generation/tip collection mode (SG/TC), whereas SECM operated in potentiometric mode was used to map the pH distribution in the electrolyte volume adjacent to the nitinol surface. Local acidification around anodic spots related to Ni 2+ discharge, as well as alkalization above the cathodic areas were observed.

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“…However, Ti-6Al-4V, being a dual-phase α + β alloy, presents a higher modulus of elasticity (125 ± 2 GPa [ 1 ]) compared with that of bone (11.4–21.2 GPa [ 2 ]). This hinders the transfer of load to the bone, and it produces a stress-shielding effect that can cause implant loosening and may result in premature bone failure [ 3 , 4 , 5 ]. Additionally, it has been pointed out that the release of V and Al ions can cause hematological and biochemical alterations, osteomalacia, peripheral neuropathy, and Alzheimer’s disease [ 4 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Surface Modified β-Ti-18Mo-6Nb-5Ta (wt%) Alloy for Bone Implant Applications: Composite Characterization and Cytocompatibility Assessment

Escobar

Careta

Navas

et al. 2023

JFB

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Commercially available titanium alloys such as Ti-6Al-4V are established in clinical use as load-bearing bone implant materials. However, concerns about the toxic effects of vanadium and aluminum have prompted the development of Al- and V-free β-Ti alloys. Herein, a new alloy composed of non-toxic elements, namely Ti-18Mo-6Nb-5Ta (wt%), has been fabricated by arc melting. The resulting single β-phase alloy shows improved mechanical properties (Young’s modulus and hardness) and similar corrosion behavior in simulated body fluid when compared with commercial Ti-6Al-4V. To increase the cell proliferation capability of the new biomaterial, the surface of Ti-18Mo-6Nb-5Ta was modified by electrodepositing calcium phosphate (CaP) ceramic layers. Coatings with a Ca/P ratio of 1.47 were obtained at pulse current densities, −jc, of 1.8–8.2 mA/cm2, followed by 48 h of NaOH post-treatment. The thickness of the coatings has been measured by scanning electron microscopy from an ion beam cut, resulting in an average thickness of about 5 μm. Finally, cytocompatibility and cell adhesion have been evaluated using the osteosarcoma cell line Saos-2, demonstrating good biocompatibility and enhanced cell proliferation on the CaP-modified Ti-18Mo-6Nb-5Ta material compared with the bare alloy, even outperforming their CaP-modified Ti-6-Al-4V counterparts.

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New Ti-6Al-2Nb-2Ta-1Mo alloy as implant biomaterial: In vitro corrosion and in vivo osseointegration evaluations

Cited by 19 publications

References 59 publications

Low-Temperature Hydrothermal Treatment Surface Functionalization of the Ultrafine-Grained TiMo Alloys for Medical Applications

Low-Temperature Hydrothermal Treatment Surface Functionalization of the Ultrafine-Grained TiMo Alloys for Medical Applications

A scanning electrochemical microscopy characterization of the localized corrosion reactions occurring on nitinol in saline solution after anodic polarization

Surface Modified β-Ti-18Mo-6Nb-5Ta (wt%) Alloy for Bone Implant Applications: Composite Characterization and Cytocompatibility Assessment

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