New topological templates for TASP design

Dumy, Pascal; Eggleston, Ian M.; Ernest, I.; Cervigni, Stefano E.; Sila, U.; Skar, Merete; Sun, Xicheng; Mutter, Manfred

doi:10.1007/978-94-011-1468-4_135

Cited by 1 publication

(1 citation statement)

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“…53 Desorption of the nitrilotriacid derivaThe protected cyclic RAFT molecule was prepared tive upon addition of etanedithiothreitol (EDTA) by a combined solid-phase and solution synthesis demonstrates the full reversibility of the process as described previously. 51 An orthogonal strategy (Figure 4a,b). The change of the resonance angle based on a combination of four Boc and two Aloc-U allows for the estimation of the NTA stoichiomeprotected lysine side chains as attachment sites was try per template and the 1:2 ratio found is consistent used to address selectively the opposite faces (or with results obtained in solution.…”

Section: Tasp As Potential Biosensorsmentioning

confidence: 98%

Protein design: On the threshold of functional properties

et al. 1998

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The ultimate goal in protein de novo design is the creation of novel macromolecules with tailor‐made receptor, sensory, and catalytic functions. Despite considerable progress in understanding basic rules of secondary structure formation and protein stability, the well‐known protein folding problem is still far from being solved and, in general, only a limited number of designed proteins are folded uniquely. In this article the state‐of‐the‐art in protein design is demonstrated on some selected examples, indicating that the construction of protein‐like macromolecules mimicking some essential features of natural proteins seems to be within reach. Thus, protein design and mimicry has become an interdisciplinary challenge with most intriguing perspectives. © 1998 John Wiley & Sons, Inc. Biopoly 47: 63–73, 1998

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Section: Tasp As Potential Biosensorsmentioning

confidence: 98%